4 research outputs found
Comprehensive Risk Assessment
- Author
- A Burlingame
- A Hayes
- A Whittemore
- AJ Lehman
- AM Schumann
- B Bridges
- C Weil
- CD Klaassen
- CS Weil
- D Gaylor
- D Gaylor
- D Hoel
- D Hoel
- D Krewski
- D Salsburg
- DJ Finney
- E Calabrese
- E Crouch
- E Portier
- EC Miller
- EJ Freireich
- F Marzulli
- Food Safety Council
- FW Carlborg
- FW Carlborg
- G Claus
- H Newmann
- I Munro
- Interagency Regulatory Liaison Group Work Group on Risk Assessment.
- International Agency for Research on Cancer.
- International Agency for Research on Cancer.
- International Commission for Protection against Environmental Mutagens and Carcinogens Committee
- J Gart
- J Knaak
- J Ramsey
- J Rodricks
- J Ryzin Van
- JK Haseman
- JV Rodricks
- JV Rodricks
- KS Crump
- L Tomatis
- N Day
- N Mantel
- N Mantel
- National Academy of Sciences.
- National Research Council
- National Research Council.
- National Research Council.
- National Research Council.
- National Research Council.
- National Research Council.
- National Research Council.
- National Research Council.
- National Research Council.
- National Research Council.
- National Research Council.
- OE Paynter
- Organization of Economic and Community Development
- P Gehring
- P Gehring
- P Gehring
- PJ Gehring
- PJ Gehring
- R Griesemer
- R Heywood
- R Kroes
- R Peto
- R Reitz
- R Squire
- RE Albert
- RG Tardiff
- RL Dixon
- RT Williams
- T Cox
- T Fishbein
- TR Fears
- U.S. Environmental Protection Agency.
- U.S. Environmental Protection Agency.
- U.S. Food and Drug Administration.
- U.S. National Toxicology Program.
- V Frankos
- WH DuMouchel
- WK Lutz
- World Health Organization
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1987
- Field of study
Toxicity Testing in the 21st Century: A Vision and a Strategy
- Author
- Abby A. Li
- Akpinar-Elci M.
- Akutsu T.
- Aranda A.
- Balls M.
- Battelle
- Benigni R.
- Benigni R.
- Bhalla U. S.
- Blount B. C.
- Charles G. D.
- Coecke S.
- Coecke S.
- Conner J. D.
- Cronin M. T.
- Daniel Acosta
- Daniel Krewski
- Food and Drug Administration
- Frankos V. H.
- Gail Charnley
- Gennari A.
- Gina M. Solomon
- Gwinn M. R.
- Henry Anderson
- IARC
- Institute of Medicine
- Institute of Medicine
- Interagency Coordinating Committee on the Validation of Alternative Methods and National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicolgical Methods
- James Yager
- John C. Bailar
- Karl T. Kelsey
- Katoh M.
- Kim Boekelheide
- Klaassen C. D.
- Kobayashi A.
- Kraska R. C.
- Landers J. P.
- Lauren Zeise
- Lawrence McCray
- Leiss W.
- Lewin B.
- Lieber M. M.
- Lockey J.
- Lutz W.
- Lydy M.
- Martin Stephens
- Masimirembwa C. M.
- Melvin Andersen
- Nancy I. Kerkvliet
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- National Research Council
- O'Brien P.
- O'Donoghue S. I.
- Otto Meyer
- Powell M. C.
- Reid D. Patterson
- Robert A. Scala
- Robert Brent
- Russell W. M. S.
- Schleger C.
- Schultz T. W.
- Sergeant A.
- Sidney Green
- Singh K. P.
- Staff of Committee on Toxicity Test
- Stephens S. M.
- Subramanya S.
- Suzuki N.
- Vedani A.
- Vivian G. Cheung
- Volarath P.
- Walker J. D.
- Wang S. L.
- William Pennie
- Woodruff T. J.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2010
- Field of study
With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a Strategy, the U.S. National Academy of Sciences, in 2007, precipitated a major change in the way toxicity testing is conducted. It envisions increased efficiency in toxicity testing and decreased animal usage by transitioning from current expensive and lengthy in vivo testing with qualitative endpoints to in vitro toxicity pathway assays on human cells or cell lines using robotic high-throughput screening with mechanistic quantitative parameters. Risk assessment in the exposed human population would focus on avoiding significant perturbations in these toxicity pathways. Computational systems biology models would be implemented to determine the dose-response models of perturbations of pathway function. Extrapolation of in vitro results to in vivo human blood and tissue concentrations would be based on pharmacokinetic models for the given exposure condition. This practice would enhance human relevance of test results, and would cover several test agents, compared to traditional toxicological testing strategies. As all the tools that are necessary to implement the vision are currently available or in an advanced stage of development, the key prerequisites to achieving this paradigm shift are a commitment to change in the scientific community, which could be facilitated by a broad discussion of the vision, and obtaining necessary resources to enhance current knowledge of pathway perturbations and pathway assays in humans and to implement computational systems biology models. Implementation of these strategies would result in a new toxicity testing paradigm firmly based on human biology
Potential Human Developmental Toxicants and The Role of Animal Testing in Their Identification and Characterization
- Author
- Abbott A.
- Abel E. L
- Abel E. L
- Abelson H. I.
- Abramovici A.
- Ai-Hatchim G. B.
- Al-Hatchim G. B.
- Aldyreva M. V.
- Allen J. R.
- Allen J. R.
- Altschuler H. L.
- Amin-Zaki L.
- Amin-Zaki L.
- Andrews J.
- Anke M.
- Anon
- Anon
- Aoki F. X.
- Arbab-Zadeh A
- Astrup P.
- Ata M. M.
- Aterman K.
- Baeder C.
- Baggs R. B.
- Bailey R. R
- Bakulina A. V
- Bantz E. W
- Barilyak I. R.
- Barnes A. B.
- Barr M
- Barsotti D. A.
- Basford A. B.
- Baxley M. N.
- Beattie A. O.
- Beaudoin A. R
- Beck F.
- Beckmann R.
- Belkina A. P
- Belyayeva A. P
- Bertrand M.
- Bethenod M.
- Bezvershenko A. S
- Bingol N.
- Bischoff F.
- Blumenthal S.
- Boice J. L
- Borgono J. M.
- Borlee I.
- Bovet-Nitti F.
- Bowman R. E.
- Bracken M. B
- Bracken M. B
- Brady K.
- Bridbord K
- Briggs G. G.
- Brown N A.
- Burbacher T. M.
- Burrow G. N.
- Burrow G. N.
- Butcher R. E.
- Butler N. R.
- Cam C
- Cam C.
- Cantu J. M.
- Casey P. H.
- Casterline J.
- Castryck F.
- Chang L. W.
- Chasnoff I. J.
- Chaube S.
- Chernoff G. F
- Chez R. A.
- Christiansen R. E
- Christiansen R. E.
- Clamon A. D.
- Clarren S. K.
- Clarren S. K.
- Clement J. G.
- Cobrinik R. W.
- Cohen E. N.
- Cohen E. N.
- Collins E.
- Collins T. F. X.
- Collins T. F. X.
- Comstock G. W.
- Corbett T. H.
- Corby D. G
- Cordero J. F.
- Coulston F.
- Coumbis J. T
- Courtney K. D
- Courtney K. D.
- Cousins L.
- Coustan D
- Covell W. P
- Cowgill V. M
- Craig G. R.
- Curtis G. W.
- Cutting R. T.
- Dagg C. P
- Dansky L.
- Datnow M. M
- Delahunt C. S.
- Delatour P.
- Denson R.
- Deskin R.
- Desoille H.
- Desoille H.
- Dexter J. D.
- Diamond I.
- Diechmann W. B.
- DiLiberti J. H.
- Dilling W.
- DiPaolo J. A
- Dolnick E. H.
- Dostal R. J. M
- Dunn H. G.
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- Eastman N. J
- Ellis F. W.
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- Endres W
- Ericson A.
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- Felisati D
- Ferguson A
- Ferm V. H.
- Ferm V. H.
- Field B.
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- Fishbein L
- Fitzek A.
- Frankenburg F. R.
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- Friedman J. M
- Fritz H.
- Fujii T.
- Fujimori H.
- Fujita E
- Gates A. H.
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- Geelen J. A. G
- Gerlinger P.
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- Gibson J. E.
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- Gibson J. E.
- Gilbert E. F.
- Gilloteaux J.
- Ginsberg M. D.
- Giroud A.
- Giuntini L.
- Gleich J
- Gofmekler V. A.
- Goldfield M. D.
- Goodfriend M. J.
- Gottschewski G. H. M
- Gralla E. J.
- Grant D. L.
- Green V. A
- Greenberg C. R.
- Greenberg L. H.
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- Groisser D. S.
- Grumbach M. M.
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- Gutova M.
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- Hackenberger I.
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- Harada M
- Harada Y
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- Hastings L.
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- Huggins G.
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- Hurley L. S.
- Hurni H.
- Illingworth R. S
- Inouye M.
- Interagency Regulatory Liaison Group
- Ishizu S.
- Ito C.
- Iwanaga R.
- Izmerov N. F
- Jacobsen L.
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- Jacquet P.
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- Kimmerle G.
- King C. T. G.
- Kinney M. D
- Kleinman J. C.
- Klosovskii B. N
- Knill-Jones R. P.
- Knill-Jones R. P.
- Konstantinova T. K
- Koos B. J.
- Kotani S.
- Krause S. O.
- Krnhart C. B.
- Kromka M.
- Krous H. F
- Kubata T
- Kucera J.
- Kullander S.
- Kunstadter P
- Kuratsune M.
- Kurppa K.
- Kurppa K.
- LaBorde J. B.
- Ladrague P
- Lammer E J.
- Landesman-Dwyer S.
- Landesman-Dwyer S.
- Lane R. E
- Laporte J. R
- Laughlin N. K
- Lauro V.
- Layton W. M.
- Lee M.
- Lemoine P.
- Lenz W
- Lenz W
- Lenz W
- Lewandowski M.
- Linn S.
- Longo L. D
- Longo L. D
- Loosli R.
- Losub S.
- Low J. A.
- Lowrance W. W
- Lubs M. E
- Lucier G. W.
- Lugo G.
- Luster M. I.
- Mactutus C. F.
- Malakhovsky V. G
- Malamud N
- Manchester D. K
- Marathe M. R.
- Marbury M. C.
- Marin-Padilla M.
- Mark-Savage P.
- Marks T. A.
- Marks T. A.
- Martin J.
- Martin J. C.
- Martin P. G.
- Masuda Y.
- Matsumoto H.
- Matsumoto N.
- Matsumoto N.
- Mau G.
- Mautner H
- McBride W. G
- McCallion D.
- McClain R. M.
- McClain R. M.
- McColl J. D.
- McLachlan J. A.
- McLachlan J. A.
- McLachlan J. A.
- McNiel J. R
- McNulty W. P
- Meadow S. R
- Meadow S. R
- Mehlman M. A.
- MeLain D. E.
- Mennuti M. T.
- Merkle J.
- Mesollela C
- Messerschmitt J
- Meyer L. S.
- Mikhailova L. M.
- Miller H. C
- Miller R. K.
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- Milunsky A.
- Minsker D. H.
- Mirkova E.
- Mizens M
- Mizunoya Y.
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- Moon J.
- Morikawa N
- Moriyama H
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- Muller G. L.
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- Myint B
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- Nixon G. S.
- Nogaki K
- Nolen G. A.
- Nomura A.
- Nonaka I
- Nora J. J.
- Nordstrom S.
- Nowack E
- Nurazyan A. G
- O'Leary J. A.
- Oakley G. P
- Oenniston G. C
- Oetkova R. P
- Oettel H.
- Ogi D.
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- Oliver T
- Onejeme A. U.
- Palludan B
- Papara-Nicholson D.
- Perm V. H.
- Persaud T. V. N.
- Peters H. A
- Peters M. A
- Petrere J. A.
- Petrov M
- Pharoah P. O. D.
- Pierce D. R.
- Pinto Machado J
- Piper J.
- Podvinec S.
- Poland B. J.
- Polednak A. P.
- Poswillo D. E.
- Potter J. D
- Prigge E
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- Pushkina N. N.
- Quibell E. P
- Ragule N. Y
- Rating D.
- Rech R. H.
- Reiter L. W.
- Rementeria J. L.
- Rice S. A.
- Richards I. D. G
- Rin K.
- Riskaer N.
- Robert E
- Robertson R. T.
- Rohrer S. R.
- Rosa F. W
- Rosa F. W.
- Rosen T. S.
- Rosenberg L.
- Rosenberg M. J
- Rosenfeld I.
- Rosett H. L
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- Samarawickrama G. P.
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- Savini E. C.
- Saxen I
- Schafer A. I
- Schardein J. L
- Schardein J. L
- Schardein J. L
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- Schoenfeld N.
- Schottek W
- Schou M.
- Schwetz B. A
- Schwetz B. A.
- Schwetz B. A.
- Schwetz B. A.
- Scott W. J.
- Selby L. A.
- Sendrowski C.
- Sever L. E.
- Shamberger R. J
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- Shaul W. L.
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- Shiono P. H.
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- Shiota K.
- Shumilina A. V
- Singh A. R.
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- Spyker J. M.
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- Staples R. E.
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- Steffek A. J.
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- Stevens W. J.
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- Stillman R. J.
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- Szentcsiki M.
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- Talens G.
- Tanaka H.
- Tanimura T
- Tanimura T.
- Tanimura T.
- Tanimura T.
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- Thomas J. A.
- Thomas J. A.
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- Tilson H. A.
- Tognoni G.
- Toledo T. M.
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- Toutant C.
- Trasler D. G
- Tze W. J.
- U.S. Environmental Protection Agency
- U.S. Environmental Protection Agency
- Ungvary G.
- Vaisman A. I
- van't Hoff W
- Vannoy J.
- Veridiano N. P.
- Villeneuve D. C.
- Villeneuve D. C.
- Villumsen A.
- Vlander A.
- Vojta M.
- Vondruska J. F.
- Vorhees C. V
- Vorhees C. V
- Vorherr H.
- Wadsworth P. F.
- Wahlstrom R. C.
- Warburton D.
- Warkany J
- Warkany J
- Warkany J
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- Warkany J.
- Weathersbee P. S.
- Weidman W. H.
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- West R. A
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- Wibberley D. G.
- Wide M
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- Wilson G. S.
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- Wilson J. G
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- Witti F. P
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- Zelson C.
- Zlobina N. S.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Risk Assessment of Carcinogenic and Noncarcinogenic Chemicals
- Author
- Abbott W. S
- Albert R. E.
- Albert R. E.
- Allen B. C.
- Altman P. L.
- Ames B. N
- Andersen M. E.
- Anderson E
- Anderson E. L.
- Anderson M. W.
- Atallah S
- Barnes D. G.
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- Berstein L.
- Bigwood E. J
- Bischoff K. B
- Bischoff K. B
- Bischoff K. B.
- Bischoff K. B.
- Bliss C. I
- Blum H. F
- Bogen K. T
- Boxenbaum H
- Brown C
- Brown C. C.
- Brown S. L.
- Bruce R. D
- Butterworth B. E
- Calabrese E. J
- Campbell D. J
- Carlborg F. W
- Carlborg F. W
- Chand N.
- Chen C. W.
- Clayson D. B
- Clewell H. J.
- Code of Federal Regulations (U.S.A.)
- Cohen B. L.
- Cohn S. M.
- Cornfield J
- Cornfield J.
- Cornfield J.
- Cothern C. R.
- Cotruvo J. A
- Covello V. T
- Cox D. R
- Cranmer M. F
- Crouch E. A. C
- Crouch E. A. C.
- Crump K. S
- Crump K. S.
- Crump K. S.
- Crump K. S.
- Crump K. S.
- Crump K. S.
- D'Souza R. W.
- D'Souza R. W.
- Day T. D
- Dourson M. L.
- Druckrey H
- EDO1 Task Force of the Society of Toxicology
- Environmental Protection Agency
- Finklea J.
- Finney D. J
- Fischoff B.
- Flamm W. G.
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food and Agriculture Organization/World Health Organization
- Food Safety Council
- Food Safety Council
- Frankos V
- Frederick R. Johannsen
- Freireich E. J.
- Fuhremann T. W.
- Gaylor D. W.
- Gaylor D. W.
- Gehring P. J.
- Gehring P. J.
- Gehring P. J.
- Gerlowski L. E.
- Gori G
- Gross M. A.
- Groupement International Des Associations Nationales De Fabricants De Produit Agrochimiques (GIFAP)
- Guess H.
- Guess H. A.
- Hartley H. O.
- Haseman J. K.
- Hattis D.
- Hayashi Y
- Hayes W. J.
- Himmelstein K. J.
- Hoel D. G
- Hoel D. G
- Hoel D. G
- Hoel D. G.
- Hogan M. D
- Huesner A. A
- Interagency Regulatory Liaison Group
- Jackson B. A
- Johannsen F. R
- Johnson E. M
- Jones H. B.
- King F. G.
- Krasovskij G. N
- Krewski D.
- Krewski D.
- Krewski D.
- Krewski D.
- Krewski D.
- Krewski D.
- Lehman A. J.
- Leung H. W.
- Lowrance W. W
- Lu F. C
- Lu F. C
- Lu F. C
- Lu F. C
- Lutz R. J.
- Mantel N.
- Mantel N.
- McGaughey C
- McNamara B. P
- Meistrich M. L
- Menzel D. B
- Miller E. C.
- Mills W. A
- Moolgavkar S.
- Moolgavkar S. H.
- Moolgavkar S. H.
- Mordenti J
- Munro I. C.
- National Academy of Sciences
- Neyman J.
- Nichols A. L.
- O'Flaherty E. J
- O'Flaherty E. J
- Occupational Safety and Health Administration (OSHA)
- Office of Science and Technology Policy (OSTP)
- Oser B. L
- Park C. N.
- Paustenbach D. J.
- Paynter O. E.
- Peto R.
- Peto R.
- Pike M. C
- Pinkel D
- Port R.
- Rai K.
- Ramsey J. C.
- Ramsey J. C.
- Ramsey J. C.
- Reitz R. H.
- Ritter L.
- Rodericks J.
- Rodericks J. V.
- Rodericks J. V.
- Salsburg D
- Schmidt-Nielsen K
- Schmähl D.
- Sielken R. L.
- Slovic P
- Somers E
- Stockinger H. E
- Taylor J. M.
- Thorslund T. W.
- Travis C. C.
- Travis C. C.
- Truhaut R
- U.S. Environmental Protection Agency
- Uchiyama M
- Van Ryzin J
- Van Ryzin J
- Van Ryzin J.
- Vettorazzi G
- Wahrendorf J
- Weil C. S
- Weil C. S.
- Weisburger J. H.
- Weisner W
- Williams G. M.
- Wilson R
- Wittmore A.
- World Health Health Organization
- World Health Organization
- World Health Organization
- World Health Organization
- Yanysheva N. Y.
- Zielhuis R. L.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study