9 research outputs found
Sepsis survivors monitoring and coordination in outpatient health care (SMOOTH): study protocol for a randomized controlled trial
Carotid Bifurcation: Evaluation of Time-resolved Three-dimensional Contrast-enhanced MR Angiography
Endovascular Treatment of Experimental Canine Aneurysms: Feasibility with MR Imaging Guidance
Assessment of Acute Renal Transplant Rejection with Blood Oxygen Level–Dependent MR Imaging: Initial Experience
Technology Insight: magnetic resonance angiography for the evaluation of patients with peripheral artery disease
Vitellogenins Are New High Molecular Weight Components and Allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris Venom
Calcium and cancer: targeting Ca2+ transport
Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted