Overcoming Memory Limitations in Rule Learning

Adults, infants, and other species are able to learn and generalize abstract patterns from sequentially presented stimuli. Rule learning of this type may be involved in children's acquisition of linguistic structure, but the nature of the mechanisms underlying these abilities is unknown. While inferences regarding the capabilities of these mechanisms are commonly made based on the pattern of successes and failures in simple artificial-language rule-learning tasks, failures may be driven by memory limitations rather than intrinsic limitations on the kinds of computations that learners can perform. Here we show that alleviating memory constraints on adult learners through concurrent visual presentation of stimuli allowed them to succeed in learning regularities in three difficult artificial rule-learning experiments where participants had previously failed to learn via sequential auditory presentation. These results suggest that memory constraints, rather than intrinsic limitations on learning, may be a parsimonious explanation for many previously reported failures. We argue that future work should attempt to characterize the role of memory constraints in natural and artificial language learning.National Science Foundation (U.S.) (NSF DDRIG #0746251)United States. Department of Education (Jacob K. Javits Graduate Fellowship

Controlled trial of fish oil for regression of human coronary atherosclerosis

AbstractObjectives. This randomized clinical trial tested whether fish oil supplements can improve human coronary atherosclerosis.Background. Epidemiologic studies of populations whose intake of oily fish is high, as well as laboratory studies of the effects of the polyunsaturated fatty acids in fish oil, support the hypothesis that fish oil is antiatherogenic.Methods. Patients with angiographically documented coronary heart disease and normal plasma lipid levels were randomized to receive either fish oil capsules (n = 31), containing 6 g of n-3 fatty acids, or olive oil capsules (n = 28) for an average duration of 28 months. Coronary atherosclerosis on angiography was quantified by computer-assisted image analysis.Results. Mean (±SD) baseline characteristics were age 62 ± 7 years, plasma total cholesterol concentration 187 ± 31 mg/dl (4.83 ± 0.80 mmol/liter) and triglyceride levels 132 ± 70 mg/dl (1.51 ± 0.80 mmol/liter). Fish oil lowered triglyceride levels by 30% (p = 0.007) but had no significant effects on other plasma lipoprotein levels. At the end of the trial, eicosapentaenoic acid in adipose tissue samples was 0.91% in the fish oil group compared with 0.20% in the control group (p < 0.0001). At baseline, the minimal lumen diameter of coronary artery lesions (n = 305) was 1.64 ± 0.76 mm, and percent narrowing was 48 ± 14%. Mean minimal diameter of atherosclerotic coronary arteries decreased by 0.104 and 0.138 mm in the fish oil and control groups, respectively (p = 0.6 between groups), and percent stenosis increased by 2.4% and 2.6%, respectively (p = 0.8). Confidence intervals exclude improvement by fish oil treatment of >0.17 mm, or >2.6%.Conclusions. Fish oil treatment for 2 years does not promote major favorable changes in the diameter of atherosclerotic coronary arteries

Cultural Differences in Perceptual Reorganization in US and Pirahã Adults

Visual illusions and other perceptual phenomena can be used as tools to uncover the otherwise hidden constructive processes that give rise to perception. Although many perceptual processes are assumed to be universal, variable susceptibility to certain illusions and perceptual effects across populations suggests a role for factors that vary culturally. One striking phenomenon is seen with two-tone images—photos reduced to two tones: black and white. Deficient recognition is observed in young children under conditions that trigger automatic recognition in adults. Here we show a similar lack of cue-triggered perceptual reorganization in the Pirahã, a hunter-gatherer tribe with limited exposure to modern visual media, suggesting such recognition is experience- and culture-specific

Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production.

The receptor activator of NF-kappaB ligand (RANKL) and the proinflammatory cytokines are believed to play important roles in osteoclastogenesis. We recently reported that the innate immune recognition receptor, Toll-like receptor 2 (TLR2), is crucial for inflammatory bone loss in response to infection by Porphyromonas gingivalis, the primary organism associated with chronic inflammatory periodontal disease. However, the contribution of macrophage-expressed TLRs to osteoclastogenesis has not been defined. In this study, we defined a requirement for TLR2 in tumor necrosis factor-alpha (TNF-alpha)-elicited osteoclastogenesis in response to exposure to P. gingivalis. Culture supernatant (CS) fluids from P. gingivalis-stimulated macrophages induced bone marrow macrophage-derived osteoclastogenesis. This activity was dependent on TNF-alpha and occurred independently of RANKL, interleukin-1beta (IL-1beta), and IL-6. CS fluids from P. gingivalis-stimulated TLR2(-/-) macrophages failed to express TNF-alpha, and these fluids induced significantly less osteoclast formation compared with that of the wild-type or the TLR4(-/-) macrophages. In addition, P. gingivalis exposure induced up-regulation of TLR2 expression on the cell surface of macrophages, which was demonstrated to functionally react to reexposure to P. gingivalis, as measured by a further increase in TNF-alpha production. These results demonstrate that macrophage-dependent TLR2 signaling is crucial for TNF-alpha-dependent/RANKL-independent osteoclastogenesis in response to P. gingivalis infection. Furthermore, the ability of P. gingivalis to induce the cell surface expression of TLR2 may contribute to the chronic inflammatory state induced by this pathogen

Minimum Information about a Neuroscience Investigation (MINI) Electrophysiology

This module represents the formalized opinion of the authors and the CARMEN consortium, which identifies the minimum information required to report the use of electrophysiology in a neuroscience study, for submission to the CARMEN system (www.carmen.org.uk).&#xd;&#xa

A map of OMC-1 in CO 9-8

The distribution of 12C16O J=9-8 (1.037 THz) emission has been mapped in OMC-1 at 35 points with 84" resolution. This is the first map of this source in this transition and only the second velocity-resolved ground-based observation of a line in the terahertz frequency band. There is emission present at all points in the map, a region roughly 4' by 6' in size, with peak antenna temperature dropping only near the edges. Away from the Orion KL outflow, the velocity structure suggests that most of the emission comes from the OMC-1 photon-dominated region, with a typical linewidthof 3-6 km/s. Large velocity gradient modeling of the emission in J=9-8 and six lower transitions suggests that the lines originate in regions with temperatures around 120 K and densities of at least 10^(3.5) cm^(-3) near theta^(1) C Ori and at the Orion Bar, and from 70 K gas at around 10^(4) cm^(-3) southeast and west of the bar. These observations are among the first made with the 0.8 m Smithsonian Astrophysical Observatory Receiver Lab Telescope, a new instrument designed to observe at frequencies above 1 THz from an extremely high and dry site in northern Chile.Comment: Minor changes to references, text to match ApJ versio

Searching for Dust Reddening in SDSS Spectra with Damped Lyman α\alpha{} Systems

We searched for evidence of reddening of background SDSS QSO spectra due to dust in intervening DLA systems. We utilise the Data Releases 5 and 7 to arrive at sample sizes of 475 (DR5) and 676 (DR7) absorbers, based on two different published lists of SDSS DLAs. Both samples span roughly the redshift range of 2.2 < z_abs < 5.2, with a mean of z~3.0, and the majority of the DLAs (75%) below z=3.3. We construct geometric mean spectra in the absorber restframes ranging from 1240 to ~2800 A, and composite spectra of samples matching the 'DLA' QSOs in i band magnitude and emission redshift z_em, but without absorption lines. By comparing the slopes of these composite spectra with their matched counterparts, we find no sign of reddening in the ensemble of the absorbers from these samples. Owing to both the unprecedently large sizes of the DLA samples themselves and the non-DLA SDSS QSO sample, from which we can draw our matching spectra, we can place very tight limits for this non-detection ( =-0.0013+-0.0025 (DR5) and =-0.0017+-0.0022 (DR7). Interestingly, when applying our technique to the samples of York et. al. (2006), vandenBerk et al. (2008) (intervening and intrinsic MgII absorbers) and the smaller DLA-subsample and pool of comparison QSOs of Vladilo et al. (2008), we do recover their results, i.e. detect the same amount of reddening as these authors do. Furthermore, we have tested whether subsamples of our large sample in categories involving the absorbers (HI column densities, presence or absence of accompanying metal absorption, absorber redshift) or the background quasars (emission redshift, brightness) do reveal dust extinction, but found no trends. These results are at odds with both detections of dust reddening from previous studies, and also with expectations from observations of high-redshift galaxies. (abridged)Comment: 16 pages, 12 figures, accepted for publication in MNRA

Covariant equations for the three-body bound state

The covariant spectator (or Gross) equations for the bound state of three identical spin 1/2 particles, in which two of the three interacting particles are always on shell, are developed and reduced to a form suitable for numerical solution. The equations are first written in operator form and compared to the Bethe-Salpeter equation, then expanded into plane wave momentum states, and finally expanded into partial waves using the three-body helicity formalism first introduced by Wick. In order to solve the equations, the two-body scattering amplitudes must be boosted from the overall three-body rest frame to their individual two-body rest frames, and all effects which arise from these boosts, including the Wigner rotations and rho-spin decomposition of the off-shell particle, are treated exactly. In their final form, the equations reduce to a coupled set of Faddeev-like double integral equations with additional channels arising from the negative rho-spin states of the off-shell particle.Comment: 57 pages, RevTeX, 6 figures, uses epsf.st