Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells

This article belongs to the Section Bioactives and Nutraceuticals.Guaiane-type sesquiterpene lactones are naturally occurring compounds which have attracted attention due to their array of biological activities. In this study, chlorinated guaianolides 1–8, isolated from plants of the genus Centaurea, were evaluated against the human leukemia cell lines HL-60, U-937, a specific U-937 cell line that overexpresses the anti-apoptotic Bcl-2 protein and the human melanoma cell line SK-MEL-1. This established the relevant structure-growth inhibition relationships. Chlorohyssopifolins A (1), C (3) and D (4) and linichlorin A (6) were the most potent compounds in terms of inducing growth inhibition in the four cell lines. IC50 values were below 10 μM in all cases. Chlorohyssopifolins A (1) and D (4) and linichlorin A (6) were potent apoptotic inducers in human U-937 leukemia cells, as determined by fluorescent microscopy and flow cytometry, and their mechanism of action was associated with cytochrome c release, caspase activation and poly(ADP-ribose)polymerase cleavage. Overall this study shows that guaianolides induce cytotoxicity against human tumor cells and provides important insights into the cell death pathways that are involved.This research was funded by FEDER and AGENCIA CANARIA DE INVESTIGACIÓN, INNOVACIÓN Y SOCIEDAD DE LA INFORMACIÓN (PROID2017010095 FEDER/ACIISI) and in part by the Spanish Ministry of Science, Innovation and Universities and the European Regional Development Fund (PGC2018-094503-B-C21)

Antonio Machado poeta de trasmuro según Juan Ramón Jiménez

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Reflexiones sobre los pilares de El rayo que no cesa

Ejemplar dedicado a: Miguel Hernández, cien añosPublicad

Poesía cruzada. Dos poemas inéditos de Leopoldo de Luis

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The picaresque novel and Pirandello

La noción de "literatura picaresca" se sitúa entra las más errantes y brumosas de la literatura comparada. El deseo de ampliar tan estricto coto ha redefinido el concepto en un sentido de "tradición picaresca", o incluso en los términos utilizados por Guillén o Blackburn, de un "mito picaresco". Visto entonces de modo dialéctico, y por vía del círculo hermenéutico, el género se enriquece y modifica continuamente con nuevas novelas. El difunto Matías Pascal, de Luigi Pirandello, exhibe elementos icónicos que remiten a la novela picaresca original y satisface los criterios mayores de dicha categoría crítica amplia. El protagonista de la novela, desde la poética del personaje picaresco y en clave evolutiva, después del intervalo romántico de héroes en su mayoría más homogéneos, redescubre el prototipo antitético de la novela crítica del seiscientos, de molde y ascendencia picaresca.The idea about picaresque novel got a place inside the most misty and wandering of the compared literature. With the purpose of expanding on that strict field, the concept has been redefine in a sense of "tradición picaresca", or even in terms used by Guillén or Blackburn, of a "mito picaresco". Then, in a dialectic way, and through the hermeutic circle, the genre is continuously enriched and modified with new novels. El difunto Matías Paseal, of Luigi Pirandello, shows iconic elements that refers to the original picaresque novel and satisfies the higher criteria of that enlarge critic category. The main character of the novel, from the poetic of the picaresque character and in a evolved key, after the romantic heroes interval mostly homogeneous, rediscover the opposite prototype of the 17th century critic novel, of origin and picaresque background.Publicad

Las voces de la poesía en los espejos del pensamiento

La página web de la revista es http://www.cuadernosdelmatematico.esPublicad

La infamia realista en Manzoni

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Nazarín, poder y lengua en Galdós

El presente ensayo crítico estudia, con atención especial a la lengua literaria, la configuración narrativa del enigmático sacerdote Nazarín protagonista de la novela homónima de Benito Pérez Galdós de finales de siglo XIX. Cómo debemos valorar a tan ambiguo personaje, cómo justipreciar la crisis de lenguaje expuesta en toda la novela. En suma, qué "imagen de la vida" y cuál análisis de la sociedad española presenta dicho texto de entresiglos.The present critical essay studies, with special attention, the literary language, the narrative configuration of the enigmatic priest Nazarín, the main character of Benito Pérez Galdós same name novel, of the last years of 19th century. How we should evaluate such an ambiguous character, how can we appreciate the language crisis showed in the entire novel. In other words, which "image of life" and what type of Spanish society analysis does the present text represent