A comparison of two models to predict nitrogen dynamics in organic agricultural systems

Two publicly available crop/soil models were compared. These were the EU-Rotate_N model (www.warwick.ac.uk/go/eurotaten) and the NDICEA model (www.ndicea.nl). Each simulation was also compared to measured data from an organically managed site in the English Midlands. Results showed that, overall, EU-Rotate_N gave a better estimation of soil mineral nitrogen, particularly after the incorporation of a long-term fertility-building crop. This model has a lot of flexibility but is aimed at researchers and requires more work before it is ready to be used by farmers or advisors. The NDICEA model is much simpler to use with a user-friendly interface

The use of computer modelling to evaluate the agronomic, economic and environmental impacts of N management in contrasting organic rotations

A new computer model (EU-ROTATE_N) has been developed with the aim of improving nitrogen management on all farms across Europe which include fi eld vegetables in their rotations. It brings together aspects of many existing models and contains a number of features to make it applicable to organic producers (e.g. taking account of nitrogen fixation by legume containing leys, nitrogen conservation by winter cover crops and nitrogen supply by manures and composts). A key feature is the model’s ability to simulate economic output and this enables it to be of value to policy makers when considering the impact of new measures to reduce environmental pollution. This paper describes the model and some initial work that has been conducted to evaluate it under UK organic field vegetable systems with contrasting fertility building strategies

National-scale modelling of N leaching in organic and conventional horticultural crop rotations - policy implications

A method is presented to model N leaching in crop rotations on a national scale. Representative crop rotations for different regions and soil types are used in the cross-disciplinary, plant, soil, environment & economics model EU-Rotate_N. By comparing contrasting farming systems (organic and conventional) in the UK, their strengths and weaknesses in delivering environmental and economic sustainability can be assessed. Modelling results show that the annual leaching in different horticultural rotations and UK regions, using median weather, is within the range of 13-88 kg N/ha/year for organic and 54-130 kg N /ha/year for conventional. The weighted annual average figures are 39 kg N/ha/year for organic and 81 kg N/ha/year for conventional, respectively. It is concluded that organic horticultural rotations, with a current share of 6.1% already contribute to lower overall N losses from agriculture. However, on a UK national scale, only a large share of organic land use (e.g. >50%) has a large effect on reducing N losses. Similar reductions are also predicted by substantial cuts in conventional N inputs, giving a policy choice if pollution from agriculture steps up further on the political agenda

Environmental and economic modelling of organic, stockless, horticultural crop rotations

Selected results from the ongoing “EU-Rotate_N” research project are presented. This EU 5th-framework project is developing a model-based decision support system to optimise nitrogen use in horticultural crop rotations across Europe. This paper introduces the economic and the fertility-building crops sub-models, and shows data from model validation and first model runs on an organic farm in central England. Preliminary results show that the model has the potential to be a powerful support tool for farmers and advisors, making decisions on rotational plan-ning. The economic, agronomic and environmental consequences of different rotational designs can be projected and assessed in detail

Acidosis slows electrical conduction through the atrio-ventricular node

Acidosis affects the mechanical and electrical activity of mammalian hearts but comparatively little is known about its effects on the function of the atrio-ventricular node (AVN). In this study, the electrical activity of the epicardial surface of the left ventricle of isolated Langendorff-perfused rabbit hearts was examined using optical methods. Perfusion with hypercapnic Tyrode's solution (20% CO2, pH 6.7) increased the time of earliest activation (Tact) from 100.5 ± 7.9 to 166.1 ± 7.2 ms (n = 8) at a pacing cycle length (PCL) of 300 ms (37°C). Tact increased at shorter PCL, and the hypercapnic solution prolonged Tact further: at 150 ms PCL, Tact was prolonged from 131.0 ± 5.2 to 174.9 ± 16.3 ms. 2:1 AVN block was common at shorter cycle lengths. Atrial and ventricular conduction times were not significantly affected by the hypercapnic solution suggesting that the increased delay originated in the AVN. Isolated right atrial preparations were superfused with Tyrode's solutions at pH 7.4 (control), 6.8 and 6.3. Low pH prolonged the atrial-Hisian (AH) interval, the AVN effective and functional refractory periods and Wenckebach cycle length significantly. Complete AVN block occurred in 6 out of 9 preparations. Optical imaging of conduction at the AV junction revealed increased conduction delay in the region of the AVN, with less marked effects in atrial and ventricular tissue. Thus acidosis can dramatically prolong the AVN delay, and in combination with short cycle lengths, this can cause partial or complete AVN block and is therefore implicated in the development of brady-arrhythmias in conditions of local or systemic acidosis

The feasibility of measuring calprotectin from a throat swab as a marker of infections caused by group A streptococcus: a case–control feasibility study

Background Most people with sore throat do not benefit from antibiotic treatment, but nearly three-quarters of those presenting in primary care are prescribed antibiotics. A test that is predictive of bacterial infection could help guide antibiotic prescribing. Calprotectin is a biomarker of neutrophilic inflammation, and may be a useful marker of bacterial throat infections.Aim To assess the feasibility of measuring calprotectin from throat swabs, and assess whether individuals with sore throats likely to be caused by streptococcal infections have apparently higher throat calprotectin levels than other individuals with sore throat and healthy volunteers.Design & setting A proof of concept case–control study was undertaken, which compared primary care patients with sore throats and healthy volunteers.Method Baseline characteristics and throat swabs were collected from 30 primary care patients with suspected streptococcal sore throat, and throat swabs were taken from 10 volunteers without sore throat. Calprotectin level determination and rapid antigen streptococcal testing were conducted on the throat swab eluents. Calprotectin levels in the following groups were compared: volunteers without a sore throat; all patients with a sore throat; patients with a sore throat testing either negative or positive for streptococcal antigen; and those with lower and higher scores on clinical prediction rules for streptococcal sore throat.Results Calprotectin was detected in all throat swab samples. Mean calprotectin levels were numerically higher in patients with sore throat compared with healthy volunteers, and sore throat patients who had group A streptococci antigen detected compared with those who did not.Conclusion Calprotectin can be measured from throat swab samples and levels are consistent with the hypothesis that streptococcal infection leads to higher throat calprotectin levels. This hypothesis will be tested in a larger study.leukocyte L1 antigen complexpharyngitisanti-bacterial agentsgroup A streptococciprimary health carecalprotectinsore throatantibiotic