A chloride channel in rat and human axons

Current recordings from single chloride channels were obtained from excised and cell-attached patches of rat and human axons. In rat axons the channels showed an outwardly rectifying current-voltage relationship with a slope conductance of 33 pS at negative membrane potentials and 65 pS at positive potentials (symmetrical 150 mM CsCl). They were measurably for cations (PNa/PCs/PCl=0.1/0.2/1). Channel currents were independent of cytoplasmatic calcium concentration. Inactivation was not observed and gating was weakly voltage dependent. Cl− channels in human axons showed similar gating behavior but had a lower conductance

Lensing constraints on ultradense dark matter halos

Cosmological observations precisely measure primordial variations in the density of the Universe at megaparsec and larger scales, but much smaller scales remain poorly constrained. However, sufficiently large initial perturbations at small scales can lead to an abundance of ultradense dark matter minihalos that form during the radiation epoch and survive into the late-time Universe. Because of their early formation, these objects can be compact enough to produce detectable microlensing signatures. We investigate whether the EROS, OGLE, and HSC surveys can probe these halos by fully accounting for finite source size and extended lens effects. We find that current data may already constrain the amplitudes of primordial curvature perturbations in a new region of parameter space, but this conclusion is strongly sensitive to yet undetermined details about the internal structures of these ultradense halos. Under optimistic assumptions, current and future HSC data would constrain a power spectrum that features an enhancement at scales $k \sim 10^7/{\rm Mpc}$, and an amplitude as low as $\mathcal{P}_\zeta\simeq 10^{-4}$ may be accessible. This is a particularly interesting regime because it connects to primordial black hole formation in a portion of the LIGO/Virgo/Kagra mass range and the production of scalar-induced gravitational waves in the nanohertz frequency range reachable by pulsar timing arrays. These prospects motivate further study of the ultradense halo formation scenario to clarify their internal structures.Comment: 17 pages, 10 figures. v2: matching published versio

The Ineludible non-Gaussianity of the Primordial Black Hole Abundance

We study the formation of primordial black holes when they are generated by the collapse of large overdensities in the early universe. Since the density contrast is related to the comoving curvature perturbation by a nonlinear relation, the overdensity statistics is unavoidably non-Gaussian. We show that the abundance of primordial black holes at formation may not be captured by a perturbative approach which retains the first few cumulants of the non-Gaussian probability distribution. We provide two techniques to calculate the non-Gaussian abundance of primordial black holes at formation, one based on peak theory and the other on threshold statistics. Our results show that the unavoidable non-Gaussian nature of the inhomogeneities in the energy density makes it harder to generate PBHs. We provide simple (semi-)analytical expressions to calculate the non-Gaussian abundances of the primordial black holes and show that for both narrow and broad power spectra the gaussian case from threshold statistics is reproduced by increasing the amplitude of the power spectrum by a factor ${\cal O}(2\div 3)$.Comment: 26 pages, 10 figures, matching published versio

Testing Primordial Black Holes as Dark Matter through LISA

The idea that primordial black holes (PBHs) can comprise most of the dark matter of the universe has recently reacquired a lot of momentum. Observational constraints, however, rule out this possibility for most of the PBH masses, with a notable exception around $10^{-12} M_\odot$. These light PBHs may be originated when a sizeable comoving curvature perturbation generated during inflation re-enters the horizon during the radiation phase. During such a stage, it is unavoidable that gravitational waves (GWs) are generated. Since their source is quadratic in the curvature perturbations, these GWs are generated fully non-Gaussian. Their frequency today is about the mHz, which is exactly the range where the LISA mission has the maximum of its sensitivity. This is certainly an impressive coincidence. We show that this scenario of PBHs as dark matter can be tested by LISA by measuring the GW two-point correlator. On the other hand, we show that the short observation time (as compared to the age of the universe) and propagation effects of the GWs across the perturbed universe from the production point to the LISA detector suppress the bispectrum to an unobservable level. This suppression is completely general and not specific to our model.Comment: 22 pages, 12 figures. v3: matching published versio

The JWST High Redshift Observations and Primordial Non-Gaussianity

Several bright and massive galaxy candidates at high redshifts have been recently observed by the James Webb Space Telescope. Such early massive galaxies seem difficult to reconcile with standard $\Lambda$ Cold Dark Matter model predictions. We discuss under which circumstances such observed massive galaxy candidates can be explained by introducing primordial non-Gaussianity in the initial conditions of the cosmological perturbations.Comment: 10 pages, 4 figure

Primordial black holes from inflation and quantum diffusion

Primordial black holes as dark matter may be generated in single-field models of inflation thanks to the enhancement at small scales of the comoving curvature perturbation. This mechanism requires leaving the slow-roll phase to enter a non-attractor phase during which the inflaton travels across a plateau and its velocity drops down exponentially. We argue that quantum diffusion has a significant impact on the primordial black hole mass fraction making the classical standard prediction not trustable.Comment: 25+12 pages, 12 figures. v3: Appendix added with comments in response to arXiv:1807.0905

Searching for Primordial Black Holes with the Einstein Telescope: impact of design and systematics

Primordial Black Holes (PBHs) have recently attracted much attention as they may explain some of the LIGO/Virgo/KAGRA observations and significantly contribute to the dark matter in our universe. The next generation of Gravitational Wave (GW) detectors will have the unique opportunity to set stringent bounds on this putative population of objects. Focusing on the Einstein Telescope (ET), in this paper we analyse in detail the impact of systematics and different detector designs on our future capability of observing key quantities that would allow us to discover and/or constrain a population of PBH mergers. We also perform a population analysis, with a mass and redshift distribution compatible with the current observational bounds. Our results indicate that ET alone can reach an exquisite level of accuracy on the key observables considered, as well as detect up to tens of thousands of PBH binaries per year, but for some key signatures (in particular high--redshift sources) the cryogenic instrument optimised for low frequencies turns out to be crucial, both for the number of observations and the error on the parameters reconstruction. As far as the detector geometry is concerned, we find that a network consisting of two separated L--shaped interferometers of 15 (20)~km arm length, oriented at $45^{\circ}$ with respect to each other performs better than a single triangular shaped instrument of 10 (15)~km arm length, for all the metrics considered.Comment: 24 pages, 13 figure

The Impact of Service Quality on Consumer Perceived Value in Medical Clinics

Service quality has been viewed as a determinant of consumer perceived value. Different dimensions of service quality have been considered by various researchers. This study identifies components of service quality of medical clinics in Jaffna.  From the coeficients table it can be seen that significance P value is less than .05 therefore all hypotheses are accepted according to the highest beta value tangibility contributes more towards customer perceived value of medical clinic services in Jaffna district. Keywords: service quality, consumer perceived value, Medical clinics, Jaffn