Sostenibilit\ue0 territoriale, turismo balneare e pratiche sportive

Il contributo proposto suggerisce una riflessione sul rapporto sempre pi\uf9 strutturato che si sta creando tra turismo balneare e sport sulla fascia della riviera adriatica che comprende le localit\ue0 di Cervia, Milano Marittima e Pinarella. I risultati finora emersi da una ricerca sociologica iniziata due anni or sono, infatti, evidenziano come in tale territorio ultimamente il ruolo dello sport quale occasione di turismo, e il turismo quale occasione di sport, conducono alla creazione di realt\ue0 tese ad offrire servizi ed eventi in cui viene costruita una vera e propria vacanza all\u2019insegna del benessere e della pratica sportiva e agonistica. Esse, a loro volta, danno poi origine a indubbie relazioni con altri settori presenti sul territorio, grazie all\u2019incoming turistico generato. Ci\uf2 che caratterizza il suddetto processo sembra in gran parte determinato dalla forte identit\ue0 locale che da sempre spinge e sostiene uno sviluppo prevalentemente autoctono volto a soddisfare un turismo che in altre localit\ue0, al contrario, vede per lo pi\uf9 imprenditori esterni rivestire un ruolo determinante. Attraverso l\u2019analisi delle principali offerte turistico-sportive e lo studio di alcuni casi emblematici si tenta, pertanto, di ipotizzare la direzione di sviluppo futuro di questo fenomeno, che da un lato sembra sfruttare ogni input e possibilit\ue0 a livello territoriale ma al contempo appare dipendere da equilibri e da forme di sostenibilit\ue0 ambientali da cui non prescinde il poter attirare e mantenere i turisti

HIV-1 Tat alters neuronal intrinsic excitability

Objective: In HIV+ individuals, the virus enters the central nervous system and invades innate immune cells, producing important changes that result in neurological deficits. We aimed to determine whether HIV plays a direct role in neuronal excitability. Of the HIV peptides, Tat is secreted and acts in other cells. In order to examine whether the HIV Tat can modify neuronal excitability, we exposed primary murine hippocampal neurons to that peptide, and tested its effects on the intrinsic membrane properties, 4 and 24 h after exposure. Results: The exposure of hippocampal pyramidal neurons to Tat for 4 h did not alter intrinsic membrane properties. However, we found a strong increase in intrinsic excitability, characterized by increase of the slope (Gain) of the input-output function, in cells treated with Tat for 24 h. Nevertheless, Tat treatment for 24 h did not alter the resting membrane potential, input resistance, rheobase and action potential threshold. Thus, neuronal adaptability to Tat exposure for 24 h is not applicable to basic neuronal properties. A restricted but significant effect on coupling the inputs to the outputs may have implications to our knowledge of Tat biophysical firing capability, and its involvement in neuronal hyperexcitability in neuroHIV

A Simple Biomimetic Receptor Selectively Recognizing the GlcNAc2 Disaccharide in Water

AbstractGlcNAc2 is the core disaccharide fragment present in N‐glycans exposed on the surface of enveloped viruses of high health concern, such as coronaviruses. Because N‐glycans are directly involved in the docking of viruses to host cells, recognition of GlcNAc2 by a biomimetic receptor may be a convenient alternative to the use of lectins to interfere with viral entry and infection. Herein, we describe a simple biomimetic receptor recognizing the methyl‐β‐glycoside of GlcNAc2 in water with an unprecedented affinity of 160 μM, exceeding that of more structurally complex receptors reported in the literature. The tweezers‐shaped acyclic structure exhibits marked selectivity among structurally related disaccharides, and complete discrimination between mono‐ and disaccharides. Molecular modelling calculations supported by NOE data provided a three‐dimensional description of the binding mode, shedding light on the origin of the affinities and selectivities exhibited by the receptor

A Variational Method for the Propagation of Spacecraft Relative Motion.

A new formulation of the spacecraft relative motion for a generic orbit is presented based on the orbital propagation method proposed by Peláez et al. in 2006 [1]. Two models have been developed. In the first model the method is applied to each spacecraft using a time synchronization of the system dynamical states. In the second model we employ a local orbital reference frame with a linearization of gravitational terms, apply the method to the formation center of mass and propagate the relative dynamics with respect to the center of mass reference orbit. The models are compared in terms of computational speed for the case of a bounded triangular formatio

Structure and magnetic properties of the cubic oxide fluoride BaFeO2F

Fluorination of the parent oxide, BaFeO3- δ, with polyvinylidine fluoride gives rise to a cubic compound with a = 4.0603(4) Å at 298K. 57Fe Mössbauer spectra confirmed that all the iron is present as Fe3+. Neutron diffraction data showed complete occupancy of the anion sites indicating a composition BaFeO2F, with a large displacement of the iron off-site. The magnetic ordering temperature was determined as TN = 645±5K. Neutron diffraction data at 4.2K established G-type antiferromagnetism with a magnetic moment per Fe3+ ion of 3.95μB. However, magnetisation measurements indicated the presence of a weak ferromagnetic moment which is assigned to the canting of the antiferromagnetic structure. 57Fe Mössbauer spectra in the temperature range 10 to 300K were fitted with a model of fluoride ion distribution that retains charge neutrality of the perovskite unit cel