ALOYSIUS LILIUS AUTHOR OF THE GREGORIAN REFORM OF THE CALENDAR

During the 16th century the disagreement between the dates of the Julian calendar, that had been in use since 46 BC and the vernal equinox, necessitated a correction to the computational rules used to regulate the flow of time. This was a very difficult task as it was necessary to resynchronize the civil time with celestial indicators, maintaining a lien adamant: the date of the vernal equinox, conventionally fixed perennially on March 21. In fact, during the Nicaea Council (325) the celebration of Easter was fixed on the first Sunday following the XIV Moon (Full Moon) belonging to the first month after the vernal equinox. Luigi Lilio, a physician, astronomer and mathematician, using imprecise astronomical data contained in tables from three centuries before, was able to elaborate a calendar that has stood the test of time. By the use of two equations he was able to synchronize the solar and lunar cycles and to develop a useful tool, named the epact cycle, to determine without uncertainty the Easter date. Furthermore, the Lilian method offers the possibility to correct the calendar according to the variation of the tropic year during time. Unfortunately, only a few details of his personal life are known. Indeed, he has left only a few faint traces in public or private archives, so that today his name is almost unknown. In this paper are reported the few details known of his life and a reconstruction of his plan for the calendar reform

feasibility analysis of coupling an orc to a mgt in a biogas plant

Abstract An increasing interest is devoted to biogas plants as they might play a key role in the reduction of current fossil fuel consumption for power production. The main component of the plant is the anaerobic digester where the organic fraction of waste products is converted in a gas with high concentration of methane and carbon dioxide. This biogas is converted in power and heat in a cogeneration unit that may consist in a micro gas turbine or an internal combustion engine. Electric power is used to satisfy the plant internal need and the surplus is sold to the grid. A portion of the heat is used to keep the digester at a constant temperature as requested by the anaerobic digestion, the reaming is generally dissipated. This study focuses on the potential of using an Organic Rankine Cycle as a possible additional thermal user to reduce the amount of dissipated heat and increase the power production. The study is based on an existing biogas plant operating in the town of Viareggio (Italy) which will be equipped with a 600kWe micro gas turbine. The integration of the two systems was studied in detail to have high values of thermal energy recovery. A reference and a modified solution were simulated in AMESim by considering a yearlong period with actual ambient conditions. Off-design behavior of all the components was also included in the simulation. The results of the investigation showed that a thermal energy recovery up to 77% could be achieved. From the economic point of view, the plant modification for introducing the ORC system has a payback period lower than 6 years and an interesting profitability index

The GM1 Ganglioside Forms GM1-Rich Gel Phase Microdomains within Lipid Rafts

Abstract: Mercury-supported, self-assembled monolayers of the sole (SAMs) dioleoylphosphatidylcholine (DOPC)and of a raft -forming mixture of DOPC, cholesterol (Chol) and palmitoylsphingomyelin of (59:26:15) mol% composition(PSM) , were investigated by electrochemical impedance spectroscopy (EIS), both in the absence and in the presence of the monosialoganglioside GM1. The impedance spectra of these four SAMs were fitted by a series of parallel combinations of a resistance and a capacitance ( RC meshes) and displayed on plots of ω Z ′ against −ω Z ″, where Z ′ and Z ″ are the in -phase and quadrature components of the impedance and is the angular frequency. A comparison among these ωdifferent impedance spectra points to the formation of GM1-rich gel phase microdomains within the lipid rafts of the DOPC/Chol/PSM mixture, thanks to the unique molecular-level smooth support provided by mercury, whichallows EIS to detect the protruding gel phase microdomains by averaging them over a macroscopically large area

Feasibility analysis of bio-methane production in a biogas plant: A case study

A feasibility analysis, to assess the suitability of converting the biogas produced in an existing anaerobic digestion plant to bio-methane, was carried out. The case study plant was equipped with a micro-gas turbine co-generator. Several upgrading systems of different sizes were considered, to determine the most suitable configuration from a thermodynamic and economic point of view. For this purpose, a model of the whole plant that included digesters, a micro-gas turbine, a sludge line, heat transfer loops, and heat exchangers was developed. A steady-state simulation was performed by using the daily average conditions for the one-year long operation of the plant. The results highlighted that the feasibility depended on the amount of bio-methane produced, as this affected the performance of the cogeneration system and the balance between the costs and revenues. When large amounts of biogas are upgraded to bio-methane, the heat provided by the micro-gas turbine during the winter season is not sufficient to keep the digesters at the desired temperature and, therefore, natural gas integration is necessary. In addition, by increasing the upgrading unit size, the amount of electric energy purchased by the grid increases accordingly. An economic analysis showed that the optimal upgrading system size was strongly dependent on the bio-methane selling price

Therapeutic Strategies in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a serious and life-threatening condition for which the prognosis remains poor. Treatment options include endothelial receptor antagonists, phosphodiesterase (PDE5) inhibitors and prostanoids. Despite all demonstrating good short-term efficacy, none of the currently available drug therapies are curative. Treatment with prostanoids is complex and requires careful monitoring and management through a specialist centre. Furthermore, clinical efficacy is dependent on adequate up-titration of the drug. Treatment should be individualised and modified according to clinical response, with the addition of other therapies if required. The importance of monitoring and modifying therapeutic regimes is discussed. There appears to be reluctance among patients and physicians to employ prostanoid therapy, though an aggressive first-line therapy may be appropriate in advanced cases

Echocardiography combined with cardiopulmonary exercise testing for the prediction of outcome in idiopathic pulmonary arterial hypertension

BACKGROUND: Right ventricular (RV) function is a major determinant of exercise intolerance and outcome in idiopathic pulmonary arterial hypertension (IPAH). The aim of the study was to evaluate the incremental prognostic value of echocardiography of the RV and cardiopulmonary exercise testing (CPET) on long-term prognosis in these patients. METHODS: One hundred-thirty treatment-naïve IPAH patients were enrolled and prospectively followed. Clinical worsening (CW) was defined by a reduction in 6-minute walk distance plus an increase in functional class, or non elective hospitalization for PAH, or death. Baseline evaluation included clinical, hemodynamic, echocardiographic and CPET variables. Cox regression modeling with c-statistic and bootstrapping validation methods were done. RESULTS: During a mean period of 528 ± 304 days, 54 patients experienced CW (53%). Among demographic, clinical and hemodynamic variables at catheterization, functional class and cardiac index were independent predictors of CW (Model-1). With addition of echocardiographic and CPET variables (Model-2), peak O2 pulse (peak VO2/heart rate) and RV fractional area change (RVFAC) independently improved the power of the prognostic model (AUC: 0.81 vs 0.66, respectively; p=0.005). Patients with low RVFAC and low O2 pulse (low RVFAC + low O2 pulse) and high RVFAC+low O2 pulse showed 99.8 and 29.4 increase in the hazard ratio, respectively (relative risk -RR- of 41.1 and 25.3, respectively), compared with high RVFAC+high O2 pulse (p=0.0001). CONCLUSIONS: Echocardiography combined with CPET provides relevant clinical and prognostic information. A combination of low RVFAC and low O2 pulse identifies patients at a particularly high risk of clinical deterioration

Stratificazione del rischio negli infarti senza onde-Q: ruolo dell'ecocardiografia a riposo e da sforzo

To assess the relation between the extent of myocardial necrosis and the presence of myocardium at risk in myocardial infarction without Q waves (NQMI) we studied by echocardiography the prevalence of jeopardized myocardium in a group of NQMI stratified on the basis of left ventricular wall motion (akinesis, hypokinesis, normal kinesis). We have studied 60 consecutive patients with non-Q myocardial infarction. Patients were examined by 2D echo at rest (V-VI day from the acute episode) and during symptoms limited bicycle ergometric test (ExT) (XX-XXX day). Regional left ventricular wall motion was evaluated as normal or asynergic (severe hypokinetic, akinetic) and the ExT was considered positive in case of new asynergic areas or ECG criteria. 2D echo at rest was technically satisfactory in 56 patients, 19 showed almost an akinetic segment (Aci) 17 had hypokinetic areas (Ipo) and 20 had normal left ventricle kinesis (Norc). Wall motion abnormalities were localized more frequently in the apex and lateral areas. During exercise 2D echo was performed in 46 patients (82%) with 23 positive tests (50%). Stratifying the population on the basis of left ventricle wall motion we observed a major number of positive tests in the group of patients with normal wall motion in comparison with those with asynergic areas at rest (Norc 66.6%, Ipo 35.7%, Aci 42.6% p less than 0.05 Nore vs Ipo and Nore vs Aci) despite the same CAD extension. These data show the heterogeneity of the NQMI that likely includes patients with transmural (asynergy group) and subendocardial MI (normal kinesis group), the latter with a higher degree of myocardium at risk

Operando SXRD study of the structure and growth process of Cu2S ultra-thin films

International audienceElectrochemical Atomic Layer Deposition (E-ALD) technique has demonstrated to be a suitable process for growing compound semiconductors, by alternating the under-potential deposition (UPD) of the metallic element with the UPD of the non-metallic element. The cycle can be repeated several times to build up films with sub-micrometric thickness. We show that it is possible to grow, by E-ALD, Cu2S ultra-thin films on Ag(111) with high structural quality. They show a well ordered layered crystal structure made on alternating pseudohexagonal layers in lower coordination. As reported in literature for minerals in the Cu-S compositional field, these are based on CuS3 triangular groups, with layers occupied by highly mobile Cu ions. This structural model is closely related to the one of the low chalcocite. The domain size of such films is more than 1000 angstrom in lateral size and extends with a high crystallinity in the vertical growth direction up to more than 10 nm. E-ALD process results in the growth of highly ordered and almost unstrained ultra-thin films. This growth can lead to the design of semiconductors with optimal transport proprieties by an appropriate doping of the intra metallic layer. The present study enables E-ALD as an efficient synthetic route for the growth of semiconducting heterostructures with tailored propertie

Exploiting the Combination of Displacement and Chemical Plating for a Tailored Electroless Deposition of Palladium Films on Copper

Various formulations for electroless deposition, to obtain continuous nanometre-sized and micrometre-sized films of palladium on copper, were compared. We deposited ultrathin films using displacement plating formulations. We obtained continuous films with an equivalent thickness between 6 and 22 nm, measured by exploiting the K-ratio method with SEM-EDS of Pd layers. The Pd films obtained in this step of the work represent a cost-effective catalytic substrate. As a second step, we selected chemical plating as the procedure to obtain palladium films with a thickness in the micrometre range. An ammonia-based Pd chemical plating bath represent one of the most effective chemical plating formulations. To prevent copper substrates from being damaged by ammonia, displacement plating with palladium was also applied as a pre-treatment to make the use of these plating baths a viable way to obtain thicker palladium coatings. Palladium films showing good adherence, compact morphology, and a thickness over 1.5 µm were obtained, proving that the combination of two different electroless techniques was the key to develop a sustainable procedure for micrometre-sized palladium coatings, which could substitute electroplating of Pd in galvanic industry for decorative applications