Observations on Cryoglobulin Testing: I. The Association of Cryoglobulins Containing Rheumatoid Factors with Manifestation of Cryoglobulinemic Vasculitis

Objective.To investigate the results of mixed cryoglobulin tests performed on patients with and without hepatitis C virus (HCV) infection, to determine whether type II cryoglobulins containing rheumatoid factor (Type II-RF) were associated with cryoglobulinemic vasculitis.Methods.The cryoglobulin test protocol differed from the routine protocol. In addition to determination of both cryoglobulin concentration and immunoglobulin composition, the presence or absence of RF concentrated in the cryoglobulins was determined.Results.A qualitative and quantitative association of Type II-RF cryoglobulins with cryoglobulinemic vasculitis was present among HCV-infected patients.Conclusion.Detection and quantification of Type II-RF may enhance clinical monitoring of cryoglobulinemic vasculitis in HCV-infected patients

Analysis of the OSU-MASLWR 001 and 002 tests by using the TRACE code

The Oregon State University (OSU) has constructed, under a U.S. Department of Energy grant, a scaled integral test facility to examine natural circulation phenomena characterizing the Multi-Application Small Light Water Reactor (MASLWR) design. The MASLWR is a small modular PWR relying on natural circulation during both steady-state and transient operation, which includes an integrated helical coil steam generator within the reactor pressure vessel. Testing has been conducted in order to assess the operation of the prototypical MASLWR under normal full pressure and full temperature conditions and to assess the passive safety systems performance. The experimental data produced are useful also for the assessment of the computational tools necessary for the operation, design and safety analysis of nuclear reactors. This report describes the assessment of TRACE code predictions, conducted under the NRC CAMP program, against the MASLWR tests OSU-MASLWR-001 and the OSU-MASLWR-002, respectively. This activity has been conducted in collaboration with the Italian National Agency for the New Technologies, Energy and Sustainable Economic Development (ENEA), the Department of Energy of the University of Palermo, the Gruppo di Ricerca Nucleare San Piero a Grado (GRNSPG) of University of Pisa, the Department of Nuclear Engineering and Radiation Health Physics at OSU and NuScale Power Inc. In particular the OSU-MASLWR-001 test, an inadvertent actuation of one submerged ADS valve, investigates the primary system to containment coupling under design basis accident conditions; the OSU-MASLWR-002 test, a natural circulation test, investigates the primary system flow rates and secondary side steam superheat for a variety of core power levels and feed water flow rates. The assessment against experimental data shows that the TRACE code predicts the main phenomena of interest of the selected tests reasonably well for most condition

A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity: in humans, genetic variations account for a relevant proportion of such variability. In the last decade the use of pharmacogenetics in clinical practice, as a tool to individualize treatment, has shown a different degree of diffusion in various clinical fields. In the field of infectious diseases, several studies identified a great number of associations between host genetic polymor-phisms and responses to antiretroviral therapy. For example, in patients treated with abacavir the screening for HLA-B*5701 before starting treatment is routine clinical practice and standard of care for all patients; efavirenz plasma levels are influenced by single nucleotide polymorphism (SNP) CYP2B6-516G> T (rs3745274). Regarding antibiotics, many studies investigated drug transporters involved in antibiotic bioavailability, especially for fluoroquinolones, cephalosporins, and antituberculars. To date, few data are available about pharmacogenetics of recently developed antibiotics such as tigecycline, daptomycin or linezolid. Considering the effect of SNPs in gene coding for proteins involved in antibiotics bioavailability, few data have been published. Increasing knowledge in the field of antibiotic pharmacogenetics could be useful to explain the high drug inter-patients variability and to individualize therapy. In this paper we reported an overview of pharmacokinetics, pharmacodynamics, and pharmacogenetics of antibiotics to underline the importance of an integrated approach in choosing the right dosage in clinical practice

Two-Photon Circularly Polarized Luminescence of Chiral Eu Complexes

We report the synthesis of chiral lanthanide complexes with extended π conjugation for efficient circularly polarized luminescence (CPL) via two-photon excitation (2PE). The pyridine bis-oxazoline (PyBox) core provides the chiral Ln3+ environment, while the extension of the conjugated backbone through the pyridine 4-position with a phenylacetylene unit increases the two-photon absorption cross section. This work presents an important step toward the development of chiral systems displaying enhanced nonlinear optical properties, with potential applications in imaging and sensing, as well as in photodynamic therapy due to the selective excitation of molecules within a specific focal volume