Progettazione Lean di una Linea di Produzione per Pannolini e Assorbenti Lavabili

Applicazione dei principi Lean nella Progettazione di una linea di Produzione, in particolare sono stati analizzati i processi produtti, i materiali impiegati e il loro rifornimento, la gestione delle scorte, la produzione con gestione pull con l'impiego del sistema kanban, il dimensionamento della linea e la configurazione del layout, una analisi economica del ritorno dell'investimento

The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts

Objectives:The aim of this study was to assess the biological rationale for the use of platelet-rich plasma (PRP) by evaluating the effect of different concentrations of PRP on osteoblasts (OB) and fibroblasts (FB) function in vitro. Materials and methods:PRP was obtained from volunteer donors using standard protocols. Primary human cultures of oral FBs and OBs were exposed to both activated and non-activated plasma as well as various concentrations of PRP (2.5 x, 3.5 x and max (4.2-5.5 x)). Cell proliferation was evaluated after 24 and 72 h using an MTT proliferation assay. Production of osteocalcin (OCN), osteoprotegerin (OPG) and transforming growth factor beta 1 (TGF-beta 1) was evaluated in OB after 24 and 72 h. Statistical analysis was performed using one-way ANOVA. Results:PRP-stimulated cell proliferation in both OBs and FBs. The effect of different PRP concentrations on cell proliferation was most notable at 72 h. The maximum effect was achieved with a concentration of 2.5 x, with higher concentrations resulting in a reduction of cell proliferation. Upregulation of OCN levels and downregulation of OPG levels were noted with increasing PRP concentrations at both 24 and 72 h. TGF-beta 1 levels were stimulated by increasing concentrations of PRP, with the increased levels being maintained at 72 h. Conclusions:PRP preparations exert a dose-specific effect on oral FBs and OBs. Optimal results were observed at a platelet concentration of 2.5 x, which was approximately half of the maximal concentrate that could be obtained. Increased concentrations resulted in a reduction in proliferation and a suboptimal effect on OB function. Hence, different PRP concentrations may have an impact on the results that can be obtained in vivo

Precise quasielastic neutrino/nucleon cross section

Quasielastic antineutrino/proton and neutrino/neutron scatterings can be well approximated by simple formulae, valid around MeV or GeV energies. We obtain a single expression valid in the whole range, and discuss its relevance for studies of supernova neutrinos, which reach intermediate energies.Comment: 12 pages. Version 2: comparison with various approximations expanded. To appear on Phys. Lett.

Influences of Age and Comorbidities on Indication for Partial Nephrectomy: A Systematic Review

BACKGROUND: The influence of age and comorbidities during decision-making for patients with renal cell carcinoma remains controversial. OBJECTIVE: To comprehensively review the available evidence regarding the impacts of age and comorbidities on the decision to perform partial nephrectomy (PN). EVIDENCE ACQUISITION: A systematic review was conducted in accordance with PRISMA and registered with PROSPERO (CRD42022344759). Only randomized control trials, prospective cohort studies, registry-based studies, or single/multi-institutional retrospective cohort studies comparing PN to other therapeutic options for cT1N0M0 renal masses were considered. The primary outcome was to assess differences in patients' baseline characteristics between different treatments in order to investigate how those aspects have influenced clinical decision-making. Finally, perioperative outcomes were compared across the different options. EVIDENCE SYNTHESIS: Overall, patients who underwent PN were 3 to 11 years younger than those who underwent other treatments. Baseline renal function was slightly better in patients who underwent PN than in those who underwent radical nephrectomy (RN), active surveillance (AS), or tumor ablation. Patients undergoing PN had an average pre-treatment eGFR 4 to 6 points (mL/min/1.73 m2) higher than patients undergoing RN or tumor ablation. Likewise, the proportion of baseline chronic kidney disease (CKD) before treatment was higher in patients undergoing other treatments, with a rate of CKD between 6% and 56% higher compared with that for PN. A slightly higher proportion of baseline diabetes mellitus (DM) and cardiovascular comorbidities (CVD) were found in patients who underwent PN than in those who underwent RN (20% vs. 21% for DM and 37% vs. 41% for CVD). On average, patients who underwent AS and tumor ablation had more comorbidities, in terms of Charlson comorbidity index (CCI), DM, and CVD (50% vs. 38% for CCI ≥2; 25% vs. 20% for DM; and 43% vs. 37% for CVD). In terms of Eastern Cooperative Oncology Group (ECOG) Performance Status and American Society of Anesthesiologists (ASA) classification, no major differences were found between PN and other treatments, but a trend emerged whereby more fit patients underwent PN compared with RN (16% of ECOG >1 for PN vs. 18% for RN and 15% of ASA grade ≥3 for PN vs. 26% for RN). Again, tumor ablation was preferred for less fit patients (31% of ASA grade ≥3). No study included in our systematic review reported the baseline frailty status of patients treated for cT1 renal masses. The rates of perioperative complications and length of hospital stay (LOS) were similar between different techniques. CONCLUSIONS: Patients who underwent PN tended to be younger and fitter than those who underwent other available treatments for cT1 renal masses. Since this technique aims at reducing renal function impairment after surgery, a greater effort should be made to optimize patient selection to include more comorbid patients for whom PN might be useful

Health and nutrition studies related to cereal biodiversity: a participatory multi-actor literature review approach

Recently, a large and growing body of literature has investigated the health potential of different wheat species. In particular, a considerable number of studies dealing with nutritional aspects has grown up around the theme of the recovery of ancient wheat varieties (species that have remained unchanged over the last hundred years). According to several studies, indeed, ancient varieties present a healthier nutritional profile than modern ones. In the framework of the European project "CERERE, CEreal REnaissance in Rural Europe: embedding diversity in organic and low-input food systems", this paper aimed to review recent research on the issue of health and nutritional cereal systems by adopting an innovative and participatory multi-actor approach which involved practitioners along with researchers. The participatory approach is the main innovation and peculiarity of this literature review. Nevertheless, the review highlights the many positive effects derived from eating whole and ancient grains such as a significant reduction in the risk of chronic diseases such as cancer, cardiovascular disease, and also a more favorable long-term weight management and increase in satiety. This review may be considered as a fruitful starting point that integrates research results to foster current and future healthier and sustainable practices in cereal systems

Comparison and combination of a hemodynamics/biomarkers-based model with simplified PESI score for prognostic stratification of acute pulmonary embolism: findings from a real world study

Background: Prognostic stratification is of utmost importance for management of acute Pulmonary Embolism (PE) in clinical practice. Many prognostic models have been proposed, but which is the best prognosticator in real life remains unclear. The aim of our study was to compare and combine the predictive values of the hemodynamics/biomarkers based prognostic model proposed by European Society of Cardiology (ESC) in 2008 and simplified PESI score (sPESI).Methods: Data records of 452 patients discharged for acute PE from Internal Medicine wards of Tuscany (Italy) were analysed. The ESC model and sPESI were retrospectively calculated and compared by using Areas under Receiver Operating Characteristics (ROC) Curves (AUCs) and finally the combination of the two models was tested in hemodinamically stable patients. All cause and PE-related in-hospital mortality and fatal or major bleedings were the analyzed endpointsResults: All cause in-hospital mortality was 25% (16.6% PE related) in high risk, 8.7% (4.7%) in intermediate risk and 3.8% (1.2%) in low risk patients according to ESC model. All cause in-hospital mortality was 10.95% (5.75% PE related) in patients with sPESI score ≥1 and 0% (0%) in sPESI score 0. Predictive performance of sPESI was not significantly different compared with 2008 ESC model both for all cause (AUC sPESI 0.711, 95% CI: 0.661-0.758 versus ESC 0.619, 95% CI: 0.567-0.670, difference between AUCs 0.0916, p=0.084) and for PE-related mortality (AUC sPESI 0.764, 95% CI: 0.717-0.808 versus ESC 0.650, 95% CI: 0.598-0.700, difference between AUCs 0.114, p=0.11). Fatal or major bleedings occurred in 4.30% of high risk, 1.60% of intermediate risk and 2.50% of low risk patients according to 2008 ESC model, whereas these occurred in 1.80% of high risk and 1.45% of low risk patients according to sPESI, respectively. Predictive performance for fatal or major bleeding between two models was not significantly different (AUC sPESI 0.658, 95% CI: 0.606-0.707 versus ESC 0.512, 95% CI: 0.459-0.565, difference between AUCs 0.145, p=0.34). In hemodynamically stable patients, the combined endpoint in-hospital PE-related mortality and/or fatal or major bleeding (adverse events) occurred in 0% of patients with low risk ESC model and sPESI score 0, whilst it occurred in 5.5% of patients with low-risk ESC model but sPESI ≥1. In intermediate risk patients according to ESC model, adverse events occurred in 3.6% of patients with sPESI score 0 and 6.65% of patients with sPESI score ≥1.Conclusions: In real world, predictive performance of sPESI and the hemodynamic/biomarkers-based ESC model as prognosticator of in-hospital mortality and bleedings is similar. Combination of sPESI 0 with low risk ESC model may identify patients with very low risk of adverse events and candidate for early hospital discharge or home treatment.

The MEG detector for μ+→e+γ decay search

The MEG (Mu to Electron Gamma) experiment has been running at the Paul Scherrer Institut (PSI), Switzerland since 2008 to search for the decay mu(+) -> e(+)gamma by using one of the most intense continuous mu(+) beams in the world. This paper presents the MEG components: the positron spectrometer, including a thin target, a superconducting magnet, a set of drift chambers for measuring the muon decay vertex and the positron momentum, a timing counter for measuring the positron time, and a liquid xenon detector for measuring the photon energy, position and time. The trigger system, the read-out electronics and the data acquisition system are also presented in detail. The paper is completed with a description of the equipment and techniques developed for the calibration in time and energy and the simulation of the whole apparatus

La valutazione ecografica della compliance del sistema venoso come indicatore di dipendenza dal precarico nel paziente ricoverato in terapia intensiva ventilato meccanicamente

Scopo del presente studio è stato quello di valutare l'andamento della collassabilità delle grandi vene in relazione alle variazioni della portata cardiaca, e in particolare determinare se, ad una variazione significativa della portata si associ una variazione analoga negli indici di distensibilità dei vasi presi in esame. Inoltre è stato proposto l'uso dell'indice di distensibilità della vena ascellare come potenziale indicatore di fluid responsiveness e di dipendenza dal precarico

The EU Mountain Product Voluntary Quality Term as a Valorization Tool for Livestock Farms: Challenges and Opportunities in an Alpine Context

European mountain areas have experienced a persistent loss of agricultural land and economic activities over time, with negative effects from both an environmental and a cultural perspective. In 2012, the European Union devised the mountain product (MP) quality term to provide to mountain producers a tool to better market their products and thus increase their income. In this article, we tried to understand what the current challenges and opportunities are concerning this quality term, focusing on meat products in the Italian Alpine context. To this end, interviews were conducted with producers who are allowed to use the term on meat in this area and with regional persons in charge of the food quality policy. The SWOT analysis performed on the results of these interviews highlights that the lack of stringent requirements and simple bureaucratic procedures are the main strengths of this tool, while the interest of consumers in mountain products is a factor that can stimulate the spread of its use. However, four crucial needs should be addressed, namely increasing consumers’ awareness of MP, providing information on MP to producers, increasing the protection of the term and developing a more collaborative approach among producers

Geothermal Power Generation in Italy 2010-2014 Update Report

ABSTRACT This paper presents an overview on the development of the Enel Green Power activities carried out in the five-year period [2010][2011][2012][2013][2014]. In Italy, the geothermal resources are mainly used for electricity generation and all of the plants in operation are located in Tuscany, in the two "historical" areas of Larderello-Travale and Mount Amiata. In the year 2013, with an installed capacity of 875.5 MW (767 MW efficient capacity), the gross electricity generation reached 5.7 billion kWh, which represents the new record of electricity produced from geothermal resource in Italy; in 2014 one additional unit (Bagnore 4) is being realized, increasing the capacity up to 914.5 MW. In the Larderello-Travale area the positive results of the deep drilling and a careful resource management with reinjection programs and chemical stimulation made it possible to increase the steam production, despite the long and intensive exploitation history. Five additional units were thus installed in the period 2009-2013 with a total capacity of 100 MW, of which only 40 MW represents a net capacity increase, while 60 MW replaced old units, decommissioned because obsolete. In the Mount Amiata area, after many years in which all activities have been stopped due to pending acceptability problems from local communities, in 2012 Enel Green Power obtained permission to resume drilling and construction activities. In the timeframe of 2012-2013 three additional units were thus installed with a total capacity of 60 MW to replace old units and some new wells have been drilled successfully. In 2013, Enel Green Power installed the first binary power plant in Italy (Gruppo Binario Bagnore3 -1 MW) which is located in Bagnore Geothermal Field (Mount Amiata) and uses the liquid phase after the primary flash of geothermal fluid. In 2015, Cornia 2 power plant will be upgraded adding a biomass fired boiler, allowing superheating of geothermal steam. This upgrading will increase the output power from 12 MW to 17.3 MW. During 2009-2013, thirty-one wells were drilled in the whole geothermal area, totaling about 100,000 meters, and 26 AMIS plants (the H 2 S and Hg abatement technology developed and patented by Enel) were installed and are currently in operation. Since 2011, Enel Green Power has begun new exploration activities in areas adjacent to the existing exploitation leases, with the main purpose to find a medium-high enthalpy fluid suitable for the production of electricity (temperature higher than 150°C)