Additional file 1: Table S1. of Health related quality of life after oesophagectomy: elderly patients refer similar eating and swallowing difficulties than younger patients

Unadjusted raw scores of selected EORTC aspects in older and younger patients. (DOC 49 kb

Effect of a short training on neonatal face-mask ventilation performance in a low resource setting - Fig 2

<p>Percentage of breaths per minute (bpm) with (a) relevant mask leak (>25%), (b) low peak inspiratory pressure (PIP<20 cm H2O), (c) peak inspiratory pressure in the recommended range (PIP = 20–35 cm H2O), and (d) high peak inspiratory pressure (PIP>35 cm H2O). <i>Data are expressed as mean (95%CI)</i>.</p

Study design.

<p>FMV—face-mask ventilation.</p

Time to diagnosis in esophageal cancer: a cohort study

<p><b>Background:</b> The association between shorter time to diagnosis and favorable outcome is still unproven in esophageal cancer. This study aims to evaluate the effect of time to diagnosis on patient prognosis.</p> <p><b>Material and methods:</b> Retrospective cohort study of all 3613 symptomatic patients referred for esophageal cancer to our center from 1980 to 2011. Time to diagnosis was calculated as the number of days from first symptom onset to the diagnosis of esophageal cancer. The main outcome measures were: resectability and severe malnutrition at diagnosis; postoperative morbidity, mortality and survival.</p> <p><b>Results:</b> Longer time to diagnosis was significantly associated with severe malnutrition at diagnosis (odds ratio (OR): 1.003, 95% confidence interval (C.I.).: 1.001–1.006) but not with resectability (OR: 0.997, 95% C.I.: 0.994–1.001). Longer time to diagnosis was not associated with postoperative morbidity (OR: 1.000, 95% C.I.: 0.998–1.003), postoperative mortality (OR: 1.002, 95% C.I.: 0.998–1.006), five-year overall survival (hazard ratio (HR): 0.999, 95% C.I.: 0.997–1.001) or five-year disease free survival (HR: 0.999, 95% C.I.: 0.998–1.001).</p> <p><b>Conclusion:</b> Longer time to diagnosis did not affect resectability, postoperative morbidity or survival. Further campaigns to raise awareness of cancer among population and primary health care providers may have limited effect on clinical outcome.</p

Time to diagnosis in esophageal cancer: a cohort study

<p><b>Background:</b> The association between shorter time to diagnosis and favorable outcome is still unproven in esophageal cancer. This study aims to evaluate the effect of time to diagnosis on patient prognosis.</p> <p><b>Material and methods:</b> Retrospective cohort study of all 3613 symptomatic patients referred for esophageal cancer to our center from 1980 to 2011. Time to diagnosis was calculated as the number of days from first symptom onset to the diagnosis of esophageal cancer. The main outcome measures were: resectability and severe malnutrition at diagnosis; postoperative morbidity, mortality and survival.</p> <p><b>Results:</b> Longer time to diagnosis was significantly associated with severe malnutrition at diagnosis (odds ratio (OR): 1.003, 95% confidence interval (C.I.).: 1.001–1.006) but not with resectability (OR: 0.997, 95% C.I.: 0.994–1.001). Longer time to diagnosis was not associated with postoperative morbidity (OR: 1.000, 95% C.I.: 0.998–1.003), postoperative mortality (OR: 1.002, 95% C.I.: 0.998–1.006), five-year overall survival (hazard ratio (HR): 0.999, 95% C.I.: 0.997–1.001) or five-year disease free survival (HR: 0.999, 95% C.I.: 0.998–1.001).</p> <p><b>Conclusion:</b> Longer time to diagnosis did not affect resectability, postoperative morbidity or survival. Further campaigns to raise awareness of cancer among population and primary health care providers may have limited effect on clinical outcome.</p

Initiation times and duration of procedures.

<p>Data are expressed as medians.</p

Detailed scores before and after the course in BMV.

<p>(see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0144443#pone.0144443.s001" target="_blank">S1 Dataset</a>). Legend: AC, after the course; BF-before the course; FM-face mask; HR- heart rate; PPV- positive pressure ventilation.</p

Detailed scores before and after the course in initial steps.

<p>(see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0144443#pone.0144443.s001" target="_blank">S1 Dataset</a>). Legend: AC, after the course; BF-before the course; HR- heart rate.</p

Total scores before and after the course in the three levels (initial steps, BMV and CC) of resuscitation.

<p>Data are expressed as median (interquartile range).</p

Representative images of esophageal lesions (H&E stain).

<p>(A) regenerative and (B and C) hyperplastic lesions within the esophageal mucosa. Original magnification 30X (A, B and C).</p