Comensamen comensarai: per una tipologia degli incipit trobadorici

L'intervento presenta una classificazione tipologica di tutti i versi incipitali della lirica in lingua d'o

Le canzoni di disamore

L'intervento illustra alcune scelte critiche operate dalle relatrici nella riedizione dei testi in lingua d'oc incentrati sul disamore

Comensamen comensarai: per una tipologia degli incipit trobadorici

Lo studio propone una tipologizzazione di tutti i circa 2500 incipit trobadorici e un'analisi della loro fortuna nelle letterature romanze medievali

COVID-19: a confirmed case of reinfection in a nurse

We describe the case of a 63-year-old man who is reported to have the first confirmed case of COVID-19 reinfection in Campania Region, Italy. We found that the two episodes were caused by virus strains with clearly different genome sequences. The patient, a retired nurse, had a very low level of antibodies IgG directed against the spike protein 14 days after his first Pfizer/BioNTek vaccine shot

"Comensamen comensarai" : uno studio tipologico sugli incipit trobadorici <br>: Colloque "Nouvelle recherche en domaine occitan : approches interdisciplinaires" (organisateur: Institut d'Etudes Occitanes, Université d'Albi).

Fonds audiovisuel du programme "ESCoM-AAR" (Equipe Sémiotique Cognitive et nouveaux Médias - Archives Audiovisuelles de la Recherche. Paris, France, 2000 - 2016).The object of our study is a typological analysis of the opening lines of the entire troubadour lyric corpus. The research focuses on the constituent elements of the first line, and aims to individuate constants and variables in each author’s production.It is widely known that the opening lines of mediaeval lyrics often operate as titles: we generally refer to the first line to designate the poem – a practice also in use in the Middle Ages – and the author himself, through the first line, provides us with a key for further interpretation. Scanning the incipit verses of more than two thousand Occitan poems, it can be observed that most of them may be grouped into typological categories, among which the following stand out: “declaration” of the genre (ex. Ab joi comensi ma chanson, BdT 16.1; Cozin, ab vos voil far tenzon, BdT 167a.1); invocation (ex. Dona, a vos me coman, BdT 296.1a; Dieus, vera vida, verais, BdT 323.16); self-pity (ex. Ailas! tan suy pessius e cossiros, BdT 257.1; Lasa, en can grieu pena, BdT 461.144a); comparison (Si cum l’arbres que, per sobrecargar, BdT 10.50; Si cum li peis an en l’aiga lor vida, BdT 30.22) ; denial (es. Non es meravelha s’eu chan, BdT 70.31; Anc ieu non l’aic, mas ella m’a, BdT 29.2).The study also focuses on the fortunes of some of these Occitan incipit in poetic production directly inspired by the troubadours.Le sujet de notre étude est l’analyse typologique de tous les incipit de la lyrique des troubadours. Notre recherche portera en particuliers sur les éléments constitutifs du premier vers, afin d’identifier les constantes et les variables dans des pièces choisies de divers auteurs.Comme on le sait, l’incipit dans la lyrique médiévale occupe souvent la fonction de titre : il sert à la fois à identifier la pièce et, pour l’auteur, à donner une première clé de lecture. En observant la liste des incipit des plus de deux mille poésies en langue d’oc, on constate que la majeure partie d’entre eux peuvent être classés dans des catégories typologiques. Parmi elles, on s’intéressera particulièrement à l’annonce du genre (ex. Ab joi comensi ma chanson, BdT 16.1; Cozin, ab vos voil far tenzon, BdT 167a.1), à l’invocation (ex. Dona, a vos me coman, BdT 296.1a; Dieus, vera vida, verais, BdT 323.16), la commisération (ex. Ailas! tan suy pessius e cossiros, BdT 257.1; Lasa, en can grieu pena, BdT 461.144a), les incipit comparatifs (ex. Si cum l’arbres que, per sobrecargar, BdT 10.50; Si cum li peis an en l’aiga lor vida, BdT 30.22), les négations (ex. Non es meravelha s’eu chan, BdT 70.31; Anc ieu non l’aic, mas ella m’a, BdT 29.2).Enfin, notre étude se concentrera sur la fortune littéraire des exordes occitanes dans les productions poétiques directement inspirées de la lyrique d’oc.Oggetto del nostro studio è l’analisi tipologica di tutti i versi incipitali della lirica trobadorica. In particolare l’indagine verterà sugli elementi costitutivi del primo verso, al fine di individuare costanti e varianti nelle scelte compositive dei diversi autori. Com’è noto, l’incipit delle liriche medievali svolge spesso la funzione di “titolo”: è con esso che ci si riferisce al componimento ed è con esso che l’autore fornisce una prima chiave di accesso. Scorrendo l’elenco degli incipit delle oltre duemila poesie in lingua d’oc, si può constatare come la maggior parte degli esordi si raggruppi attorno a precisi nuclei tipologici. Tra questi, ricoprono particolare interesse le autodesignazioni del genere (es. Ab joi comensi ma chanson, BdT 16.1; Cozin, ab vos voil far tenzon, BdT 167a.1), le invocazioni (es. Dona, a vos me coman, BdT 296.1a; Dieus, vera vida, verais, BdT 323.16), le autocommiserazioni (es. Ailas! tan suy pessius e cossiros, BdT 257.1; Lasa, en can grieu pena, BdT 461.144a), gli incipit comparativi (Si cum l’arbres que, per sobrecargar, BdT 10.50; Si cum li peis an en l’aiga lor vida, BdT 30.22), le negazioni (es. Non es meravelha s’eu chan, BdT 70.31; Anc ieu non l’aic, mas ella m’a, BdT 29.2).Infine, lo studio si concentrerà sulla fortuna incontrata dagli esordi occitani nelle produzioni poetiche direttamente ispiratesi alla lirica in lingua d’oc

Down-regulation of MicroRNAs 222/221 in Acute Myelogenous Leukemia with Deranged Core-Binding Factor Subunits12

Core-binding factor leukemia (CBFL) is a subgroup of acutemyeloid leukemia (AML) characterized by genetic mutations involving the subunits of the core-binding factor (CBF). The leukemogenesis model for CBFL posits that one, or more, gene mutations inducing increased cell proliferation and/or inhibition of apoptosis cooperate with CBF mutations for leukemia development. One of the most commonmutations associated with CBF mutations involves the KIT receptor. A high expression of KIT is a hallmark of a high proportion of CBFL. Previous studies indicate that microRNA (MIR) 222/221 targets the 3′ untranslated region of the KIT messenger RNA and our observation that AML1 can bind the MIR-222/221 promoter, we hypothesized that MIR-222/221 represents the link between CBF and KIT. Here, we show that MIR-222/221 expression is upregulated after myeloid differentiation of normal bone marrow AC133+ stem progenitor cells. CBFL blasts with either t(8;21) or inv(16) CBF rearrangements with high expression levels of KIT (CD117) display a significantly lower level of MIR-222/221 expression than non-CBFL blasts. Consistently, we found that the t(8;21) AML1-MTG8 fusion protein binds the MIR-222/221 promoter and induces transcriptional repression of a MIR-222/221-LUC reporter. Because of the highly conserved sequence homology, we demonstrated concomitant MIR-222/221 down-regulation and KIT up-regulation in the 32D/WT1 mouse cell model carrying the AML1-MTG16 fusion protein. This study provides the first hint that CBFL-associated fusion proteins may lead to up-regulation of the KIT receptor by down-regulating MIR-222/221, thus explaining the concomitant occurrence of CBF genetic rearrangements and overexpression of wild type or mutant KIT in AML

A specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer

Purpose: MicroRNAs (miRNAs) are small, non-coding RNA molecules that can be down- or up-regulated in colorectal cancer and have been associated to prognosis and response to treatment. We studied miRNA expression in tumor biopsies of patients with rectal cancer to identify a specific “signature” correlating with pathological complete response (pCR) after neoadjuvant chemo-radiotherapy. Methods and Materials: 38 T3-4/N+ rectal cancer patients received capecitabine-oxaliplatin and radiotherapy followed by surgery. Pathologic response was scored according to the Mandard TRG scale. MiRNA expression was analysed by microarray and confirmed by RT-PCR on frozen biopsies obtained before treatment. The correlation between miRNA expression and TRG, coded as TRG1 (pCR) versus TRG >1 (no pCR), was assessed by methods specifically designed for this study. Results: Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by RT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909*, miR-630, miR-765) were significantly up-regulated in TRG1 patients, 2 (miR-1274b, miR-720) were down-expressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases. Conclusions: A set of 13 miRNAs is strongly associated with pCR and may represent a specifi