Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans

The study of Drosophila neurodegenerative mutants combined with genetic and biochemical analyses lead to the identification of multiple complex mutations in 60 patients with a novel form of ataxia/leukoencephalopathy

Prenatal Iron Deficiency in Guinea Pigs Increases Locomotor Activity but Does Not Influence Learning and Memory.

The objective of the current study was to determine whether prenatal iron deficiency induced during gestation in guinea pigs affected locomotor activity and learning and memory processes in the progeny. Dams were fed either iron-deficient anemic or iron-sufficient diets throughout gestation and lactation. After weaning, all pups were fed an iron-sufficient diet. On postnatal day 24 and 40, the pups' locomotor activity was observed within an open-field test, and from postnatal day 25 to 40, their learning and memory processes were assessed within a Morris Water Maze. The behavioural and cognitive tests revealed that the iron deficient pup group had increased locomotor activity, but solely on postnatal day 40, and that there were no group differences in the Morris Water Maze. In the general discussion, we propose that prenatal iron deficiency induces an increase in nervousness due to anxiety in the progeny, which, in the current study, resulted in an increase of locomotor activity

Etude de la reconstitution des flux de chaleur et de quantite de mouvement a partir des donnees de la campagne ECLAP

Available at INIST (FR), Document Supply Service, under shelf-number : 26165 C, issue : a.1996 n.11 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Mean path distance (a) and mean escape latency (b) of IS and IDA groups as a function of blocks of trials in the acquisition phase of the MWM.

<p>Mean percentage of path distance in target quadrant (c) and mean percentage of time spent in the target quadrant (d) as a function of group during the MWM retention phase (Dots illustrate individual scores of all IS (black square dots) and IDA pups (black circle dots)). Mean path distance (e) and mean escape latency (f) of IS and IDA groups as a function of sessions in the inversion phase of the MWM. Error bars represent 95% confidence intervals.</p

Iron status for IS and IDA guinea-pig dams¹ and pups² (M).

<p>¹ IS (<i>n</i> = 10) and IDA (<i>n</i> = 8)</p><p>² IS (<i>n</i> = 26) and IDA (<i>n</i> = 14).</p><p>Iron status for IS and IDA guinea-pig dams<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133168#t001fn001" target="_blank">¹</a> and pups<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133168#t001fn002" target="_blank">²</a> (M).</p

Median (horizontal bar) and individual scores of all IS (black square dots) and IDA pups (black circle dots) for (a) the total cell crossings, (b) the percentage of cells in the enclosure visited, (c) the percentage of time in the four corners of the enclosure and (d) the percentage of time spent in the guinea pig’s most visited cell in Session 2 of the OFT (PNd40).

<p>* Significant after Bonferroni correction for non-independent tests (<i>α</i> = 0.025).</p

Birth outcomes for IS and IDA guinea-pig dams¹ (M ± SEM).

<p>¹ IS (<i>n</i> = 10) and IDA (<i>n</i> = 8).</p><p>Birth outcomes for IS and IDA guinea-pig dams<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133168#t002fn001" target="_blank">¹</a> (M ± SEM).</p