24 research outputs found
A flexible strategy for the divergent modification of pleuromutilin
No full textInternational audienceThe complex antibacterial natural product, pleuromutilin, can be directly modified by the radical addition reaction of various xanthates to the unactivated terminal olefin present on C-12
A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes
No full textInternational audience(Matrix presented) A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered
Hémisynthèse d'analogues et approches à la synthèse totale de la pleuromutiline
No full textPALAISEAU-Polytechnique (914772301) / SudocSudocFranceF
A mild exchange reaction of xanthates with bromine
No full textInternational audienceSecondary S-alkyl-O-ethyl (or O-neopentyl) xanthates can be converted into the corresponding bromides by heating with ethyl 2-bromo-2-methylpropionate and cumyl peroxide in refluxing chlorobenzene; this transformation can be coupled to a xanthate transfer radical addition to an olefin
