38 research outputs found
Partial sequence and toxic effects of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
A neurotoxic peptide, granulitoxin (GRX), was isolated from the sea anemone Bunodosoma granulifera. The N-terminal amino acid sequence of GRX is AKTGILDSDGPTVAGNSLSGT and its molecular mass is 4958 Da by electrospray mass spectrometry. This sequence presents a partial degree of homology with other toxins from sea anemones such as Bunodosoma caissarum, Anthopleura fuscoviridis and Anemonia sulcata. However, important differences were found: the first six amino acids of the sequence are different, Arg-14 was replaced by Ala and no cysteine residues were present in the partial sequence, while two cysteine residues were present in the first 21 amino acids of other toxins described above. Purified GRX injected ip (800 µg/kg) into mice produced severe neurotoxic effects such as circular movements, aggressive behavior, dyspnea, tonic-clonic convulsion and death. The 2-h LD50 of GRX was 400 ± 83 µg/kg
On exact solutions for quintessential (inflationary) cosmological models with exponential potentials
We first study dark energy models with a minimally-coupled scalar field and
exponential potentials, admitting exact solutions for the cosmological
equations: actually, it turns out that for this class of potentials the
Einstein field equations exhibit alternative Lagrangians, and are completely
integrable and separable (i.e. it is possible to integrate the system
analytically, at least by quadratures). We analyze such solutions, especially
discussing when they are compatible with a late time quintessential expansion
of the universe. As a further issue, we discuss how such quintessential scalar
fields can be connected to the inflationary phase, building up, for this class
of potentials, a quintessential inflationary scenario: actually, it turns out
that the transition from inflation toward late-time exponential quintessential
tail admits a kination period, which is an indispensable ingredient of this
kind of theoretical models. All such considerations have also been done by
including radiation into the model.Comment: Revtex4, 10 figure
Arcabouço cronoestratigráfico da Formação Mafra (intervalo médio) na região de Rio Negro/PR - Mafra/SC, borda leste da bacia do Paraná
Exponential Potentials for Tracker Fields
We show that a general, exact cosmological solution, where dynamics of scalar
field is assigned by an exponential potential, fulfils all the issues of dark
energy approach, both from a theoretical point of view and in comparison with
available observational data. Moreover, tracking conditions are discussed, with
a new treatment of the well known condition . We prove that the
currently used expression for is wrong.Comment: 29 pages,12 figures; contact [email protected]; revised version, to
appear in Physical Review