Nachweis der Amplifikation von Genen im Bereich von 12q13 im Epithel von odontogenen Zysten unter besonderer Berücksichtigung des keratozystischen odontogenen Tumors

Die in der Literatur beschriebenen, klassischen histologischen Charakteristika sind insbesondere bei entzündlicher Überlagerung des Epithels nicht immer eindeutig zu erkennen. Folglich besteht der Bedarf nach einer verläßlichen Methode, um den KZOT eindeutig diagnostizieren und damit eine Abgrenzung zu den nicht-neoplastischen odontogenen Zysten ermöglichen zu können. Unter 494 Patientenfällen fielen alle Patienten (n = 134), die an einem KZOT im Zeitraum von 1993 bis 2010 erkrankt waren und deren Biopsiematerial verfügbar war. Die differentialdiagnostisch wichtigen Krankheiten der Kontrollgruppe, das sind die follikulären und radikulären Zysten, wurden auf etwa 100 Fälle begrenzt, da diese im allgemeinen wesentlich häufiger als KZOTs auftreten. Neben den odontogenen Zysten dienten dem Vergleich auch das Basalzellkarzinom (n = 20) und das Ameloblastom (n = 50). Mittels Fluoreszenz-in-situ-Hybridisierung konnte bei 375 Fällen, worunter sich 124 KZOTs befanden, zwar der Bereich des in der Literatur beschriebenen Amplikon 12q13.1-12q13.3 insbesondere in den Epithelzellkernen des KZOT markiert und ausgewertet werden, eine Amplifikation fand sich jedoch weder in den KZOT-Fällen noch in den Fällen der nicht-neoplastischen odontogenen Zysten, des Basalzellkarzinoms und des Ameloblastoms

New maverick coset theories

We present new examples of maverick coset conformal field theories. They are closely related to conformal embeddings and exceptional modular invariants.Comment: 6 pages, LaTeX2

Low-dose intranasal versus oral midazolam for routine body MRI of claustrophobic patients

The purpose of this study was to assess prospectively the potential of low-dose intranasal midazolam compared to oral midazolam in claustrophobic patients undergoing routine body magnetic resonance imaging (MRI). Seventy-two adult claustrophobic patients referred for body MRI were randomly assigned to one of two treatment groups (TG1 and TG2). The 36 patients of TG1 received 7.5mg midazolam orally 15min before MRI, whereas the 36 patients of TG2 received one (or, if necessary, two) pumps of a midazolam nasal spray into each nostril immediately prior to MRI (in total, 1 or 2mg). Patients' tolerance, anxiety and sedation were assessed using a questionnaire and a visual analogue scale immediately before and after MRI. Image quality was evaluated using a five-point-scale. In TG1, 18/36 MRI examinations (50%) had to be cancelled, the reduction of anxiety was insufficient in 12/18 remaining patients (67%). In TG2, 35/36 MRI examinations (97%) were completed successfully, without relevant adverse effects. MRI image quality was rated higher among patients of TG2 compared to TG1 (p<0.001). Low-dose intranasal midazolam is an effective and patient-friendly solution to overcome anxiety in claustrophobic patients in a broad spectrum of body MRI. Its anxiolytic effect is superior to that of the orally administrated for

Effects of Feedback-Supported Online Training during the Coronavirus Lockdown on Posture in Children and Adolescents

(1) Background. The coronavirus pandemic had a serious impact on the everyday life of children and young people with sometimes drastic effects on daily physical activity time that could have led to posture imbalances. The aim of the study was to examine whether a six-week, feedbacksupported online training programme could improve posture parameters in young soccer players. (2) Methods. Data of 170 adolescent soccer players (age 15.6 ± 1.6 years) were analyzed. A total of 86 soccer players of a youth academy participated in an online training program that included eight exercises twice per week for 45 min (Zoom group). The participants’ exercise execution could be monitored and corrected via smartphone or laptop camera. Before and after the training intervention, participants’ posture was assessed using photographic analysis. The changes of relevant posture parameters (perpendicular positions of ear, shoulder and hips, pelvic tilt, trunk tilt and sacral angle) were statistically tested by robust mixed ANOVA using trimmed means. Postural parameters were also assessed post hoc at 8-week intervals in a control group of 84 participants of the same age. (3) Results. We found a statistically significant interaction (p < 0.05) between time and group for trunk tilt, head and shoulder protrusion and for hip anteversion in the Zoom group. No changes were found for these parameters in the control group. For pelvic tilt no significant changes were found. (4) Conclusions. Feedback-based online training with two 45 min sessions per week can improve postural parameters in adolescent soccer players over a period of six weeks

USPIO-enhanced MRI for preoperative staging of gynecological pelvic tumors: preliminary results

The aim of this study was to assess nodal enhancement with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) during preoperative staging of gynecological pelvic tumors within the same imaging session for the primary tumor. Pelvic MRI was performed 18-28h after intravenous infusion of USPIO (Combidex/Sinerem, 2.6mg Fe/kg body weight) in 13 women (mean age 51 years) scheduled for surgery for biopsy proven (n=11) or clinically suspected (n=2) uterine carcinoma. Axial T1-weighted spin-echo (SE), T2-weighted fast SE (FSE; with fat saturation), fast spoiled gradient-recalled (FSPGR) echo, sagittal and oblique T2-weighted FSE sequences were acquired on a 1.5-T system. Lymph nodes were prospectively staged using standard criteria, i.e., size and shape, as well as USPIO enhancement. Results were correlated with histology findings. MRI correctly staged all primary uterine tumors. In one case, the preoperative diagnosis of stage IV switched the therapeutic approach to radiochemotherapy. Ninety-one (86 benign, 5 malignant) of the histologically characterized nodes could be correlated with their MRI counterparts. One node was false positive; three micrometastases greater than 5mm and one 5-mm metastasis were missed. On a nodal basis, the sensitivity score was 0.33 and the specificity score, 0.99. On a patient basis, the sensitivity score was 0.25 and the specificity score, 0.80. Our preliminary results indicate that USPIO-enhanced pelvic MRI for preoperative nodal assessment is feasible within one imaging session for primary tumors and that it has a high specificity. However, the low sensitivity in the present study is a limitation for the clinical application of this techniqu

Simultaneous quantization of edge and bulk Hall conductivity

The edge Hall conductivity is shown to be an integer multiple of $e^2/h$ which is almost surely independent of the choice of the disordered configuration. Its equality to the bulk Hall conductivity given by the Kubo-Chern formula follows from K-theoretic arguments. This leads to quantization of the Hall conductance for any redistribution of the current in the sample. It is argued that in experiments at most a few percent of the total current can be carried by edge states.Comment: 6 pages Latex, 1 figur