Manajemen Program Siaran Lokal Aceh TV Dalam Upaya Penyebarluasan Syariat Islam Dan Pelestarian Budaya Lokal

Managing broadcasting management is not easy. Managing the broadcasting business is a difficult and challenging. This research aims to analyze the activity of management and organizational performance ACEH TV television media in an effort to disseminate the Islamic Sharia and Preservation of Local Culture in Aceh. This research is descriptive qualitative. Informants of this research is managing director, program director, executive producer, cameraman / reporter, as well as additional informants Regional Chairman of the Indonesian Broadcasting Commission (KPID) Aceh, Aceh Province Department of Islamic Law, and local media observers. The location of this research is in Banda Aceh, Aceh province. Sampling was done purposively. Data collected through observation, interviews, and documentation. Data were analyzed by analysis of an interactive model of Miles and Huberman. The results showed that the ACEH TV as the medium of television that is broadcasting management ACEH have done according to a local television broadcasting standard. Agenda setting function of mass media performed in the ACEH TV dissemination of Islamic Shariah in Aceh and local culture to influence the people of Aceh to implement Islamic Sharia and also maintain the culture and local wisdom Aceh. It can be seen from all the programs that are aired ACEH TV is a program of local cultural nuances of Islamic law. There are still some shortcomings in running broadcasting broadcasting technology such as lack of equipment that is increasingly sophisticated. The results of image editing is very simple, and some programs presenter still looks stiff when in front of the camera

Additional file 4: of Familial resemblances in human whole blood transcriptome

Probe pairs showing a significant genetic correlation (n = 25). List of all 25 probe pairs that showed a significant (P ≤ 0.05) genetic correlation between gene expression and DNA methylation levels. (XLSX 10 kb

Additional file 5: of Familial resemblances in human whole blood transcriptome

Overrepresented pathways identified among genes of probes with a familial effect (n = 1211). Table describing all 140 significant overrepresented pathways identified from gene expression analysis (IPA canonical pathways, associated P-value, and list of differentially expressed genes). (XLSX 18 kb

Additional file 2: of Familial resemblances in human whole blood transcriptome

Distribution of common environmental effect estimates for gene expression levels of A) all probes (n = 18,160), B) significant probes (n = 1211). Histogram of common environmental effect estimates for all and significant probes. (TIF 481 kb

Additional file 7: of Familial resemblances in human whole blood transcriptome

Common overrepresented pathways identified among genes with significant familial effect in gene expression levels (n = 1211) and DNA methylation (n = 6291). Table describing all 22 significant overrepresented pathways in common between genes with significant familial effect in gene expression and DNA methylation levels (IPA canonical pathways and list of differentially expressed genes). (XLSX 10 kb

Additional file 6: of Familial resemblances in human whole blood transcriptome

Overrepresented pathways identified among genes of CpG with a familial effect (n = 6291). Table describing all 75 significant overrepresented pathways identified from DNA methylation analysis (IPA canonical pathways, associated P-value, and list of differentially methylated genes). (XLSX 17 kb

Familial resemblances in blood leukocyte DNA methylation levels

<p>Epigenetic factors such as DNA methylation are DNA alterations affecting gene expression that can convey environmental information through generations. Only a few studies have demonstrated epigenetic inheritance in humans. Our objective is to quantify genetic and common environmental determinants of familial resemblances in DNA methylation levels, using a family based sample. DNA methylation was measured in 48 French Canadians from 16 families as part of the GENERATION Study. We used the Illumina HumanMethylation450 BeadChip array to measure DNA methylation levels in blood leukocytes on 485,577 CpG sites. Heritability was assessed using the variance components method implemented in the QTDT software, which partitions the variance into polygenic (G), common environmental (C), and non-shared environmental (E) effects. We computed maximal heritability, genetic heritability, and common environmental effect for all probes (12.7%, 8.2%, and 4.5%, respectively) and for statistically significant probes (81.8%, 26.9%, and 54.9%, respectively). Higher maximal heritability was observed in the Major Histocompatibility Complex region on chromosome 6. In conclusion, familial resemblances in DNA methylation levels are mainly attributable to genetic factors when considering the average across the genome, but common environmental effect plays an important role when considering statistically significant probes. Further epigenome-wide studies on larger samples combined with genome-wide genotyping studies are needed to better understand the underlying mechanisms of DNA methylation heritability.</p

Additional file 1: of Familial resemblances in human whole blood transcriptome

Distribution of genetic heritability estimates for gene expression levels of A) all probes (n = 18,160), B) significant probes (n = 1211). Histogram of genetic heritability estimates for all and significant probes. (TIF 491 kb

Additional file 1: of Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation

Differentially methylated probes after the n-3 FA supplementation. Description of data: List of all 308 differentially methylated probes (FDR-corrected DiffScore ≥│13│~ P ≤ 0.05). (XLSX 42 kb

Additional file 1: of Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes

Results from every deletion experiment in the article as well as the assignment of gene essentiality for optimal growth from the 6 cell-lines of the two studies used in the validation of the network. (XLSX 54 kb