Pathways to scale: Retrofitting One Million+ homes

Australia needs a targeted and coordinated effort to retrofit the millions of existing homes. This report presents the foundational research that will underpin an effort to engage private finance to begin by retrofitting over one million Australian homes for thermal and energy efficiency. The scheme aims to retrofit homes so that they can support Australia’s current and future comfort and energy needs and facilitate the transition to renewable energy. The way we generate and use energy is transforming. Our homes need to evolve alongside this to support our needs for comfort, efficiency, and resilience. Maximising thermal and energy efficiency in homes, moving energy demand into periods of maximum renewable generation, and enabling electrification can also support the transition toward net zero. Based on modelling in this report, retrofitting one million existing Australian homes across five years could: • Reduce average home energy use by up to 9,000kWh per year • Reduce average home emissions by up to 5.8 tonnes CO2 eq per year • Create an up to $55 billion private finance investment opportunity A bespoke home retrofit, addressing needs identified through a whole-of-home assessment could reduce an average home energy bill by up to$1,600 per year. A large-scale home retrofit scheme can create jobs for Australian communities, reduce energy use for heating and cooling and cut carbon emissions whilst stimulating private investment. This is evidenced by international retrofit programs. This project reviewed eight international programs from the United Kingdom, Europe, United States of America, and New Zealand. These programs demonstrated that large-scale retrofits can be effectively implemented and yield positive impacts including stimulate investment, save energy, reduce greenhouse gas emission, increase employment and local business activity, provide good return on investment of public money (1:4+), create health benefits for home occupants and increase property value. The research outlined in this report supports development of a public-private partnership to retrofit one million plus homes, across five years. It recommends that a large-scale home retrofit scheme aims to create future ready homes. That is; improved thermal comfort with a path toward electrification. The report outlines key insights to inform the design and implementation of an effective retrofit scheme. It then recommends a suite of coordinated actions required from stakeholders across the Australian home retrofit ecosystem to support a large-scale scheme. It also paves the way for a longer-term research program that can fill gaps in our current understanding to maximise the effectiveness of home retrofits at scale. There is a substantial market opportunity in Australia. The task ahead is large and complex, yet feasible through collaborative efforts. And now more than ever before. The PAGE 4 Pathways to Scale: Retrofitting One Million+ Homes insights for effective retrofit scheme design and recommendations for a portfolio of coordinated action outlined in this report can guide this effort and transform Australia’s existing homes for a prosperous, net-zero emissions future

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

Enabling residential hybrid water systems through a water credit-debit system

Smart metering and data analytics enable the implementation of a range of on-site infrastructures for energy, water and waste management to demonstrate the interconnected infrastructure of future smart cities. A research project in Western Australia is integrating smart metering technology, household participation and data analytics. An improved understanding of hybrid water systems at residential scale, as socially accepted solutions to promote water efficiency and economic savings, within the traditional centralized urban water network is achieved. An integrated water model and a system of water credits and debits are developed and tested on a case study for which 10-minute logged water consumption data of its hybrid water system are available for 1 year. The model is shown to provide a full characterization of the relationship between the household and the water resources, thus assisting with improved urban water management which promotes the rollout of decentralized hybrid water systems whilst accounting for the impacts on the aquifer as an ecosystem service provider

COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive for SARS-CoV-2 from May 26 to July 1, 2021 (Delta overwhelmingly the predominant circulating UK variant), compared (1:1, age- and sex-matched) with individuals presenting from December 28, 2020 to May 6, 2021 (Alpha (B.1.1.7) the predominant variant). We assessed illness (symptoms, duration, presentation to hospital) during Alpha- and Delta-predominant timeframes; and transmission, reinfection, and vaccine effectiveness during the Delta-predominant period. 3581 individuals (aged 18 to 100 years) from each timeframe were assessed. The seven most frequent symptoms were common to both variants. Within the first 28 days of illness, some symptoms were more common with Delta versus Alpha infection (including fever, sore throat, and headache) and some vice versa (dyspnoea). Symptom burden in the first week was higher with Delta versus Alpha infection; however, the odds of any given symptom lasting ≥ 7 days was either lower or unchanged. Illness duration ≥ 28 days was lower with Delta versus Alpha infection, though unchanged in unvaccinated individuals. Hospitalisation for COVID-19 was unchanged. The Delta variant appeared more (1.49) transmissible than Alpha. Re-infections were low in all UK regions. Vaccination markedly reduced the risk of Delta infection (by 69-84%). We conclude that COVID-19 from Delta or Alpha infections is similar. The Delta variant is more transmissible than Alpha; however, current vaccines showed good efficacy against disease. This research framework can be useful for future comparisons with new emerging variants

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit