Lithospheric failure on Venus

We develop a predictive model which has the ability to explain a postulated style of episodic plate tectonics on Venus, through the periodic occurrence of lithospheric subduction events. Present-day incipient subduction zones are associated with the existence of arcuate trenches on the Venusian lithosphere. These trenches resemble terrestrial subduction zones, and occur at the rim of coronae, uplift features thought to be due to deep-mantle convective plumes. The model we adopt represents the lithosphere as the thermal boundary layer which lies above a convective plume. We assume a temperature-dependent nonlinear viscoelastic rheology, and we assume a stress-based criterion for plastic yield. In developing this latter criterion, we are led to a re-interpretation of the strength envelope which is commonly used in analysing lithospheric stress, and we propose that the plastic yield strength has meaning (and is finite) below the lithosphere, using behaviour in the Earth as our 'laboratory' justification for this view. An inferred yield stress on the Earth is ca. 300 bar (30 MPa). Our model then shows that a thickening lithosphere becomes progressively more fluid as the stresses induced by the buoyant convective plume become large. Failure occurs when the effective lithosphere viscosity becomes equal to that of the underlying mantle. We show that reasonable expected values of yield stress in the range 100-200 bar (10-20 MPa) for Venusian mantle rocks are consistent within the framework of the model with radii of coronal trenches in the range 100-1200 km, and with the approximate time (200-800 Myr) which they may take to develop

Experimental characterization of deployable trusses and joints

The structural dynamic properties of trusses are strongly affected by the characteristics of joints connecting the individual beam elements. Joints are particularly significant in that they are often the source of nonlinearities and energy dissipation. While the joints themselves may be physically simple, direct measurement is often necessary to obtain a mathematical description suitable for inclusion in a system model. Force state mapping is a flexible, practical test method for obtaining such a description, particularly when significant nonlinear effects are present. It involves measurement of the relationship, nonlinear or linear, between force transmitted through a joint and the relative displacement and velocity across it. An apparatus and procedure for force state mapping are described. Results are presented from tests of joints used in a lightweight, composite, deployable truss built by the Boeing Aerospace Company. The results from the joint tests are used to develop a model of a full 4-bay truss segment. The truss segment was statically and dynamically tested. The results of the truss tests are presented and compared with the analytical predictions from the model

Bone marrow transplantation alters the tremor phenotype in the murine model of globoid-cell leukodystrophy

Tremor is a prominent phenotype of the twitcher mouse, an authentic genetic model of Globoid-Cell Leukodystrophy (GLD, Krabbe’s disease). In the current study, the tremor was quantified using a force-plate actometer designed to accommodate low-weight mice. The actometer records the force oscillations caused by a mouse’s movements, and the rhythmic structure of the force variations can be revealed. Results showed that twitcher mice had significantly increased power across a broad band of higher frequencies compared to wildtype mice. Bone marrow transplantation (BMT), the only available therapy for GLD, worsened the tremor in the twitcher mice and induced a measureable alteration of movement phenotype in the wildtype mice. These data highlight the damaging effects of conditioning radiation and BMT in the neonatal period. The behavioral methodology used herein provides a quantitative approach for assessing the efficacy of potential therapeutic interventions for Krabbe’s disease

Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep

We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary gonadal (HPG) function in sheep. This study investigated whether exposure to ECs only during preconceptional period or only during pregnancy perturbed key regulatory genes within the hypothalamus and pituitary gland and whether these effects were different from chronic (life-long) exposure to biosolid ECs. The findings demonstrate that the timing and duration of maternal EC exposure influences the subsequent effects on the fetal neuroendocrine system in a sex-specific manner. Maternal exposure prior to conception or during pregnancy only, altered the expression of key fetal neuroendocrine regulatory systems such as GnRH and kisspeptin to a greater extent than when maternal exposure was ‘life-long’. Furthermore, hypothalamic gene expression was affected to a greater extent in males than in females, and following EC exposure, male fetuses expressed more “female-like” mRNA levels for some key neuroendocrine genes. This is the first study to show that “real-life” maternal exposure to low levels of a complex cocktail of chemicals prior to conception can subsequently affect the developing fetal neuroendocrine system. These findings demonstrate that the developing neuroendocrine system is sensitive to EC mixtures in a sex-dimorphic manner likely to predispose to reproductive dysfunction in later life