Chimpanzee Signing: Darwinian Realities and Cartesian Delusions

Truly discontinuous, all-or-none phenomena must be rare in nature. Historically, the great discontinuities have turned out to be conceptual barriers rather than natural phenomena. They have been passed by and abandoned rather than broken through in the course of scientific progress. The sign language studies in chimpanzees have neither sought nor discovered a means of breathing humanity into the soul of a beast. They have assumed instead that there is no discontinuity between verbal behavior and the rest of human behavior or between human behavior and the rest of animal behavior—no barrier to be broken, no chasm to be bridged, only unknown territory to be explored

Scholarship in Review 84(2)

Scholarship in Review was a magazine highlighting research and scholarly activities at Central Washington University, published by the Office of Graduate Studies and Research.https://digitalcommons.cwu.edu/scholarship_in_review/1000/thumbnail.jp

Biological Roles of the O-Methyl Phosphoramidate Capsule Modification in Campylobacter jejuni.

Campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, and the capsular polysaccharide (CPS) of this organism is required for persistence and disease. C. jejuni produces over 47 different capsular structures, including a unique O-methyl phosphoramidate (MeOPN) modification present on most C. jejuni isolates. Although the MeOPN structure is rare in nature it has structural similarity to some synthetic pesticides. In this study, we have demonstrated, by whole genome comparisons and high resolution magic angle spinning NMR, that MeOPN modifications are common to several Campylobacter species. Using MeOPN biosynthesis and transferase mutants generated in C. jejuni strain 81-176, we observed that loss of MeOPN from the cell surface correlated with increased invasion of Caco-2 epithelial cells and reduced resistance to killing by human serum. In C. jejuni, the observed serum mediated killing was determined to result primarily from activation of the classical complement pathway. The C. jejuni MeOPN transferase mutant showed similar levels of colonization relative to the wild-type in chickens, but showed a five-fold drop in colonization when co-infected with the wild-type in piglets. In Galleria mellonella waxmoth larvae, the MeOPN transferase mutant was able to kill the insects at wild-type levels. Furthermore, injection of the larvae with MeOPN-linked monosaccharides or CPS purified from the wild-type strain did not result in larval killing, indicating that MeOPN does not have inherent insecticidal activity

Beatrix (Trixie) Gardner -- A Tribute

Central Washington Univeristy, US

Beatrix (Trixie) Gardner -- A Tribute

Central Washington Univeristy, US