13 research outputs found

    The CIC metadata portal: A collaborative effort in the area of digital libraries

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    Article copies available from The Haworth Document Delivery Service: 1-800-HAWORTH | [email protected] | http://www.HaworthPress.com/The CIC consortium includes 12 major Midwestern Universities. Their libraries have decided to share the cost of a joint project (2003-2006) aimed at better understanding the mechanisms by which emerging technologies and standards can facilitate metadata sharing and the creation of value-added services for their users. The CIC metadata portal project has performed advanced work in the area of Open Archives Initiative Protocol for Metadata Harvesting, collection level descriptions, metadata transformation and enrichment, and practices and usability of metadata standards. It has provided an opportunity for increased collaboration between CIC academic libraries and a way to highlight the wealth of digital resources held by the participating libraries. This article describes the project and enumerates project accomplishments. The project has helped to better the way in which partner institutions share information about digital content and provide access to digital resources. Four content providers of the project highlight different aspects of the project and the practical benefits they found in the collaboration.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58774/1/STL_Foulonneau.pd

    ACO2 clinicobiological dataset with extensive phenotype ontology annotation

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    Pathogenic variants of the aconitase 2 gene (ACO2) are responsible for a broad clinical spectrum involving optic nerve degeneration, ranging from isolated optic neuropathy with recessive or dominant inheritance, to complex neurodegenerative syndromes with recessive transmission. We created the first public locus-specific database (LSDB) dedicated to ACO2 within the "Global Variome shared LOVD" using exclusively the Human Phenotype Ontology (HPO), a standard vocabulary for describing phenotypic abnormalities. All the variants and clinical cases listed in the literature were incorporated into the database, from which we produced a dataset. We followed a rational and comprehensive approach based on the HPO thesaurus, demonstrating that ACO2 patients should not be classified separately between isolated and syndromic cases. Our data highlight that certain syndromic patients do not have optic neuropathy and provide support for the classification of the recurrent pathogenic variants c.220C>G and c.336C>G as likely pathogenic. Overall, our data records demonstrate that the clinical spectrum of ACO2 should be considered as a continuum of symptoms and refines the classification of some common variants.Molecular Technology and Informatics for Personalised Medicine and Healt

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    Abstract: The CIC consortium includes 12 major Midwestern Universities. Their libraries have decided to share the cost of a joint project (2003-2006) aimed at better understanding the mechanisms by which emerging technologies and standards can facilitate metadata sharing and the creation of value-added services for their users. The CIC metadata portal project has performed advanced work in the area of Open Archives Initiative Protocol for Metadata Harvesting, collection level descriptions, metadata transformation and enrichment, practices and usability of metadata standards. It has provided an opportunity for increased collaboration between CIC academic libraries and a way to highlight the wealth of digital resources held by the participating libraries. This article describes the project and enumerates project accomplishments. The project has helped to better the way in which partner institutions share information about digital content and provide access to digital resources. Four content provider of the project highlight different aspects of the project and the practical benefits they found in the collaboration

    Factors influencing grapevine vigour and the potential for control with partial rootzone drying

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    Maintaining the most cost-effective balance between vegetative and reproductive growth is one of the most testing problems in modern viticulture. Grapevines which exhibit excessive vegetative vigour are likely to produce less fruit of reduced quality, and vines with inadequate vigour may be compromised in terms of their yield potential. The requirement for techniques to better manage excess vigour has become more acute in recent years with the increased use of irrigation, adoption of vigour-imparting rootstocks and the expansion of vineyards into cooler geographic regions. A number of strategies may be used to control vine vigour. Chemical growth regulators, although capable of reducing shoot vigour, have never received acceptance due to undesirable side effects and concerns over chemical residues. Devigorating rootstocks, likewise, may have the potential to control vigour but none are in wide commercial use. Restriction of the effective root volume, achieved through manipulation of planting densities, competition by cover crops, regulation of the soil volume wetted by drip irrigation or regulation of water availability can all achieve a degree of devigoration but often at the expense of fruit yield. Manipulation of vines through pruning and trellis design are probably the most commonly used methods for the control of shoot vigour. A high number of nodes retained at pruning combined with trellises which allow open canopies have proved successful. Advances in the understanding of the physiological factors influencing shoot growth and transpiration have allowed the development of novel irrigation methods for the control of vine vigour. These techniques exploit the fact that chemical signals originating in the roots are primarily responsible for the control of shoot growth and transpiration. Stimulation of the production of these signals through partial drying of the root system results in a significant reduction in shoot growth and water-use while maintaining crop yield and improving fruit quality. These new techniques, in combination with appropriate pruning and trellising methods, are providing new viticultural tools for controlling vine vigour and water-use efficiency
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