Hyperbetaglobulinemia and lgG subclasses in dogs: study of 50 cases

Sur 50 cas d’élévation isolée et en bloc des globulines bêta du sérum de chien en électrophorèse sur acétate de cellulose, l’immunoélectrophorèse fait la preuve d’une augmentation de la sous-classe IgG 1. Pour la majorité, 32 sujets, cette réaction évoque un dysfonctionnement de l’immunité cellulaire : affections cutanées de mauvais pronostic, maladies systémiques. Dans d’autres cas (6 parasitoses), il pourrait s’agir d’une réponse plusspécifique à certains antigènes.We present 50 cases of elevation of serum beta globulins in the dog, detected by cellulose acetate electrophoresis. Immunoelectrophoresis shows that this reaction depends upon a IgGl subclass elevation. In most of the cases (32), this suggests a cellular immunity disease : cutaneous affections of bad prognosis, systemic diseases. In other cases (6 parasitosis), this could be a more specific response to some antigens

Prenatal Treatment for Serious Neurological Sequelae of Congenital Toxoplasmosis: An Observational Prospective Cohort Study

Background: The effectiveness of prenatal treatment to prevent serious neurological sequelae (SNSD) of congenital toxoplasmosis is not known.Methods and Findings: Congenital toxoplasmosis was prospectively identified by universal prenatal or neonatal screening in 14 European centres and children were followed for a median of 4 years. We evaluated determinants of postnatal death or SNSD defined by one or more of functional neurological abnormalities, severe bilateral visual impairment, or pregnancy termination for confirmed congenital toxoplasmosis. Two-thirds of the cohort received prenatal treatment (189/293; 65%). 23/293 (8%) fetuses developed SNSD of which nine were pregnancy terminations. Prenatal treatment reduced the risk of SNSD. The odds ratio for prenatal treatment, adjusted for gestational age at maternal seroconversion, was 0.24 (95% Bayesian credible intervals 0.07-0.71). This effect was robust to most sensitivity analyses. The number of infected fetuses needed to be treated to prevent one case of SNSD was three (95% Bayesian credible intervals 2-15) after maternal seroconversion at 10 weeks, and 18 (9-75) at 30 weeks of gestation. Pyrimethamine-sulphonamide treatment did not reduce SNSD compared with spiramycin alone (adjusted odds ratio 0.78, 0.21-2.95). The proportion of live-born infants with intracranial lesions detected postnatally who developed SNSD was 31.0% (17.0%-38.1%).Conclusion: The finding that prenatal treatment reduced the risk of SNSD in infected fetuses should be interpreted with caution because of the low number of SNSD cases and uncertainty about the timing of maternal seroconversion. As these are observational data, policy decisions about screening require further evidence from a randomized trial of prenatal screening and from cost-effectiveness analyses that take into account the incidence and prevalence of maternal infection

EPILEPSIE POST-TRAUMATIQUE PRECOCE DANS L'ENFANCE. SIGNIFICATION ET PRONOSTIC A COURT TERME

In the last 5 yr, 244 children with head traumas were observed. Early post-traumatic epilepsy was present in 11% of the patients. This complication was more frequent in children less than 6 yr of age or presenting a previous neurological history. Early posttraumatic epilepsy was rarely associated with brain concussion and frequently with cerebral contusion. An intracranial hematoma was not encountered in the absence of the classical signs of expanding space occupying lesions.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Enregistrement continu de l'EEG

A continuous EEG recording device (Oxford Medical System) was utilized in 158 patients with overt epileptic seizures and atypical fits of questionable origin. This technique proved a valuable tool in assessing EEG paroxysmal activity. The validity of the results is discussed and emphasis is laid on the numerous pitfalls and obvious limitations of the method which do not allow a temporal correlation between EEG findings and clinical events. © 1982 Elsevier Biomedical Press, Amsterdam.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

A new spike-wave detection algorithm showing high sensitivity, low false positive rate and reduced computing time permits a good detection of electrical status epilepticus during slow sleep (ESES).

info:eu-repo/semantics/publishe

A new, simultaneously objective and patient-specific, spike and wave detection algorithm based on template matching.

info:eu-repo/semantics/publishe

Relationship between the characteristics of slow-wave components and cognitive impairment in rolandic epilepsy.

info:eu-repo/semantics/publishe

Regional brain blood flow in congenital dysphasia: Studies with technetium-99m HM-PAO SPECT

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Spike detection algorithm automatically adapted to individual patients applied to spike-and-wave percentage quantification.

To report an innovative spike detection algorithm that tailors its detection to the patient. Interictal epileptiform activity quantification was accomplished in the setting of epileptic syndromes with continuous spike and waves during slow sleep, which is a time-consuming task for the EEG analysis.info:eu-repo/semantics/publishe

Multiple exostoses, mental retardation, hypertrichosis, and brain abnormalities in a boy with a de novo 8q24 submicroscopic interstitial deletion

Multiple exostoses represent a genetically heterogeneous disorder that may occur isolated or as part of a complex contiguous gene syndrome such as Langer-Giedion syndrome on chromosome 8 and the proximal 11p deletion syndrome on chromosome 11. Here we describe a boy with multiple exostoses, hypertrichosis, mental retardation, and epilepsy due to a de novo deletion on chromosome 8q24. Molecular analysis revealed that the deletion interval overlaps with the Langer-Giedion syndrome and involves the EXT1 gene and additional genes located distal to EXT1, but probably not encompassing the TRPS1 gene located proximal to EXT1. (C) 2002 Wiley-Liss, Inc