Auditory Temporal Processes in the Elderly

Several studies have reported age-related decline in auditory temporal resolution and in working memory. However, earlier studies did not provide evidence as to whether these declines reflect overall changes in the same mechanisms, or reflect age-related changes in two independent mechanisms. In the current study we examined whether the age-related decline in auditory temporal resolution and in working memory would remain significant even after controlling for their shared variance. Eighty-two participants, aged 21-82 performed the dichotic temporal order judgment task and the backward digit span task. The findings indicate that age-related decline in auditory temporal resolution and in working memory are two independent processes

Stimulus-Onset-Asynchrony as the Main Cue in Temporal Order Judgment

Elderly individuals often complain of difficulties in understanding speech, especially when heard against a background noise or when there are multiple speakers[...

Auditory temporal processing as a specific deficit among dyslexic readers

Abstract The present study focuses on examining the hypothesis that auditory temporal perception deficit is a basic cause for reading disabilities among dyslexics. This hypothesis maintains that reading impairment is caused by a fundamental perceptual deficit in processing rapid auditory or visual stimuli. Since the auditory perception involves a number of mechanisms, and temporal processing is only one of them, in the current paper we tested, in addition to auditory temporal processing, also auditory intensity and spectral processing among dyslexic and normal readers. In addition, we examined whether poor performance of dyslexic readers in auditory temporal processing tasks results from a difficulty in working memory, by testing differences in auditory processing, controlling for working memory. Thirty-seven adult dyslexic readers and 40 adult normal readers performed a battery of tests measuring auditory temporal processing (gap detection and dichotic temporal order judgment), auditory intensity processing (absolute threshold and intensity discrimination), auditory spectral processing (spectral temporal order judgment), and working memory (backward digit span). Performance on auditory spectral and temporal processing task was poorer among dyslexic readers, as compared to normal readers, even after controlling for working memory, but no difference was found on intensity processing tasks. These results suggest that dyslexic readers exhibit a specific deficit in auditory temporal processing, which cannot be attributed either to general perceptual deficit in auditory processing, or to working memory

Physical co-morbidity among treatment resistant vs. treatment responsive patients with major depressive disorder

Co-morbid physical illness has been suggested to play an important role among the factors contributing to treatment resistance in patients with major depressive disorder. In the current study we compared the rate of physical co-morbidity, defined by ICD-10, among a large multicenter sample of 702 patients with major depressive disorder. A total of 356 of the participants were defined as treatment resistant depression (TRD) patients-having failed two or more adequate antidepressant trials. No significant difference was found between TRD and non-TRD participants in the prevalence of any ICD-10 category. This finding suggests that although physical conditions such as diabetes, thyroid dysfunction, hypertension, ischemic heart disease, and peptic diseases are often accompanied by co-morbid MDD, they do not necessarily have an impact on the course of MDD or the likelihood to respond to treatment. Marginally higher rates of co-morbid breast cancer, migraine and glaucoma were found among TRD participants. Possible explanations for these findings and their possible relation to TRD are discussed