Is sleep disruption a trigger for postpartum psychosis?

An episode of postpartum psychosis can be devastating for a woman and her family, and it is vital we understand the factors involved in the aetiology of this condition. Sleep and circadian rhythm disruption is a plausible candidate but further research is needed that builds on the latest advances in chronobiology and neuroscience

Monitoring Training Load Using the Acute: Chronic Workload Ratio in Non-Elite Intercollegiate Female Athletes

Monitoring training load and its progression in athletes is important to optimise adaptations to training while simultaneously preventing injury. A recent development in this field is the acute: chronic workload ratio (ACWR), which track s average acute training load against average chronic training load to describe training load progression. Furthermore, a new method of calculating the ACWR has been developed using exponentially weighted moving averages (EWMA) which accounts for the decay of fitness and fatigue. This study sought to investigate the relationship between the EWMA and ACWR (based upon session rating of perceived exertion (sRPE)), and injury risk in intercollegiate female athletes (N=4). Participants performed adductor squeeze tests (ASTs) once a week for 8 week s, while their training and wel lness were monitored with sRPE and a daily questionnaire respectively. A hierarchical regression demonstrated that monitoring of average sleep length, average stress, sRPE work loads and an EWMA provided the best model for predicting injury risk in athletes (R2 = 0.47). The findings indicate that the EWMA may be a effective training load monitoring tool than the ACWR model

What helps Christians grow? An exploratory study distinguishing among four distinctive pathways

This study draws on a detailed survey completed by 1,123 churchgoers attending churches within the West Midlands region of England in order to identify indicators of Christian growth and distinctive pathways to growth. Factor and reliability analyses distinguished between two indicators of Christian growth (depth of discipleship and strength of vocation) and four distinctive pathways to growth (growth through group activity, growth through Christian experience, growth through church worship, and growth through public engagement). Regression analyses, taking into account individual differences in sex, age, education, church support and challenges to faith, identified growth through Christian experience as the most important factor in helping Christians to grow, while public engagement added weight to depth of discipleship and group activities added weight to strength of vocation. The implications of these findings are discussed for future research and for Discipleship Learning programmes within the Church

Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx: The MeRInO study

Introduction and background: A significant proportion of patients with intermediate and high risk squamous cell cancer of the oropharynx (OPSCC) continue to relapse locally despite radical chemoradiotherapy (CRT). The toxicity of the current combination of intensified dose per fraction radiotherapy and platinum based chemotherapy limits further uniform intensification. If a predictive biomarker for outcomes from CRT can be identified during treatment then individualised and adaptive treatment strategies may be employed. Methods/design: The MeRInO study is a prospective observational imaging study of patients with intermediate and high risk, locally advanced OPSCC receiving radical RT or concurrent CRT Patients undergo diffusion weighted MRI prior to treatment (MRI_1) and during the third week of RT (MRI_2). Apparent diffusion coefficient (ADC) measurements will be made on each scan for previously specified target lesions (primary and lymph nodes) and change in ADC calculated. Patients will be followed up and disease status for each target lesion noted. The primary aim of the MeRInO study is to determine the threshold change in ADC from baseline to week 3 of RT that may identify the sub-group of non-responders during treatment. Discussion: The use of DW-MRI as a predictive biomarker during RT for SCC H&N is in its infancy but studies to date have found that response to treatment may indeed be predicted by comparison of DW-MRI carried out before and during treatment. However, previous studies have included all sub-sites and biological sub-types. Establishing ADC thresholds that predict for local failure is an essential step towards using DW-MRI to improve the therapeutic ratio in treating SCC H&N. This would be done most robustly in a specific H&N sub-site and in sub-types with similar biological behaviour. The MeRInO study will help establish these thresholds in OPSCC

'The heart of what we do': policies on teaching, learning and assessment in the learning and skills sector

One of the stated aims of government policy in England is to put teaching, training,and learning at the heart of the learning and skills system. This paper provides a critical review of policies on teaching, learning and assessment in the learning and skills sector over the past five years. It draws upon data collected and analysed in the early stages of an ESRC-funded Teaching and Learning Research Programme project. Using evidence from policy sources, we argue that despite policy rhetoric about devolution of responsibility to the 'front line', the dominant 'images' that government has of putting teaching, learning and assessment at the heart of the Learning and Skills Sector involves a narrow concept of learning and skills; an idealisation of learner agency lacking an appreciation of the pivotal role of the learner/tutor relationship and a top-down view of change in which central government agencies are relied on to secure education standards

Sediment source fingerprinting as an aid to catchment management: a review of the current state of knowledge and a methodological decision-tree for end-users

The growing awareness of the environmental significance of fine-grained sediment fluxes through catchment systems continues to underscore the need for reliable information on the principal sources of this material. Source estimates are difficult to obtain using traditional monitoring techniques, but sediment source fingerprinting or tracing procedures, have emerged as a potentially valuable alternative. Despite the rapidly increasing numbers of studies reporting the use of sediment source fingerprinting, several key challenges and uncertainties continue to hamper consensus among the international scientific community on key components of the existing methodological procedures. Accordingly, this contribution reviews and presents recent developments for several key aspects of fingerprinting, namely: sediment source classification, catchment source and target sediment sampling, tracer selection, grain size issues, tracer conservatism, source apportionment modelling, and assessment of source predictions using artificial mixtures. Finally, a decision-tree representing the current state of knowledge is presented, to guide end-users in applying the fingerprinting approach