Biodegradable PLGA Based Nanoparticles for Sustained Regional Lymphatic Drug Delivery

The purpose of this work is to evaluate biodegradable drug carriers with defined size, hydrophobicity, and surface charge density for preferential lymphatic uptake and retention for sustained regional drug delivery. PLGA–PMA:PLA-PEG (PP) nanoparticles of defined size and relative hydrophobicity were prepared by nanoprecipitation method. These were compared with PS particles of similar sizes and higher hydrophobicity. PLGA–PMA:PLGA-COOH (PC) particles at 80:20, 50:50, and 20:80 ratios were prepared by nanoprecipitation for the charge study. Particle size and zeta potential were characterized by dynamic light scattering and laser doppler anemometry, respectively. Particles were administered in vivo to rats subcutaneously. Systemic and lymph node uptake was evaluated by marker recovery. Lymphatic uptake and node retention of PP nanoparticles was shown to be inversely related to size. Lymphatic uptake and node retention of PP particles, as compared to PS particles, was shown to be inversely related to hydrophobicity. Lastly, lymphatic uptake and node retention of PC nanoparticles were directly related to the anionic charge on the particles. In vivo lymphatic uptake and retention in a rat model indicates that the 50 nm PP particles are ideal for sustained regional delivery into the lymphatics for prevention/treatment of oligometastases

Implementing efficient concerted rotations using Mathematica and C code

In this article we demonstrate a general and efficient metaprogramming implementation of concerted rotations using Mathematica. Concerted rotations allow the movement of a fixed portion of a polymer backbone with fixed bending angles, like a protein, while maintaining the correct geometry of the backbone and the initial and final points of the portion fixed. Our implementation uses Mathematica to generate a C code which is then wrapped in a library by a Python script. The user can modify the Mathematica notebook to generate a set of concerted rotations suited for a particular backbone geometry, without having to write the C code himself. The resulting code is highly optimized, performing on the order of thousands of operations per second

Flacelière (Robert). Inscriptions de la terrasse du Temple et de la région nord du Sanctuaire. Nos. 87-275.

Forrest W.G. Flacelière (Robert). Inscriptions de la terrasse du Temple et de la région nord du Sanctuaire. Nos. 87-275. . In: Revue belge de philologie et d'histoire, tome 34, fasc. 2, 1956. pp. 539-542

Amandry (Pierre). La Colonne des Naxiens et le Portique des Athéniens Jannoray (Jean). Le Gymnase (Relevés et dessins de Henry Ducoux)

Forrest W.G. Amandry (Pierre). La Colonne des Naxiens et le Portique des Athéniens Jannoray (Jean). Le Gymnase (Relevés et dessins de Henry Ducoux). In: Revue belge de philologie et d'histoire, tome 33, fasc. 4, 1955. pp. 993-996