Exploring New Ultrafast Operation Regimes in Quantum Dot Lasers and Amplifiers

We will present our recent results, harnessing the flexibility of quantum dot materials towards the development of increasingly versatile regimes of ultrashort pulse generation and amplification in edge-emitting devices

Reproducibility of measurements of oestrogen-receptor concentration in breast cancer.

The reproducibility of measurements of oestrogen-receptor activity has been examined in multiple specimens from a rabbit uterus, a rat mammary tumour and human breast tumours. The relationship between receptor concentration and tumour histology has also been investigated in 11 large primary tumours. In the animal tissues, receptor measurements were relatively reproducible (coefficient of variance: wet wt. basis 16-17%, protein basis 16-21%) but in human breast tumours receptor activity varied considerably (c.v.: wet wt. basis, 22-125%; protein basis, 28-72%). In addition to these variations in receptor activity within tumours, there was a difference between tumours, as demonstrated by an analysis of variance (P less than 0.01). In the 11 primary breast cancers selected for study, the level of receptor activity was related to menopausal status and the tumour content of the specimen. We conclude that the receptor activity detected varies within a tumour and depends upon the tumour content of the biopsy specimen. Predictions based on precise quantitation of receptor concentrations may therefore necessitate replicate tumour sampling and correction for the fraction of non-tumour tissue in each sample

Slow dynamics near glass transitions in thin polymer films

The $\alpha$-process (segmental motion) of thin polystyrene films supported on glass substrate has been investigated in a wider frequency range from 10$^{-3}$ Hz to 10$^4$ Hz using dielectric relaxation spectroscopy and thermal expansion spectroscopy. The relaxation rate of the $\alpha$-process increases with decreasing film thickness at a given temperature above the glass transition. This increase in the relaxation rate with decreasing film thickness is much more enhanced near the glass transition temperature. The glass transition temperature determined as the temperature at which the relaxation time of the $\alpha$-process becomes a macroscopic time scale shows a distinct molecular weight dependence. It is also found that the Vogel temperature has the thickness dependence, i.e., the Vogel temperature decreases with decreasing film thickness. The expansion coefficient of the free volume $\alpha_f$ is extracted from the temperature dependence of the relaxation time within the free volume theory. The fragility index $m$ is also evaluated as a function of thickness. Both $\alpha_f$ and $m$ are found to decrease with decreasing film thickness.Comment: 9 pages, 7 figures, and 2 table

Report of the direct infrared sensors panel

The direct infrared sensors panel considered a wide range of options for technologies relevant to the science goals of the Astrotech 21 mission set. Among the technologies assessed are: large format arrays; photon counting detectors; higher temperature 1 to 10 micro-m arrays; impurity band conduction (IBC) or blocked impurity band (BIB) detectors; readout electronics; and adapting the Space Infrared Telescope Facility and Hubble Space Telescope. Detailed development plans were presented for each of these technology areas

Fully Sampled Maps of Ices and Silicates in Front of Cepheus A East with Spitzer

We report the first fully sampled maps of the distribution of interstellar CO2 ices, H2O ices and total hydrogen nuclei, as inferred from the 9.7 micron silicate feature, toward the star-forming region Cepheus A East with the IRS instrument onboard the Spitzer Space Telescope. We find that the column density distributions for these solid state features all peak at, and are distributed around, the location of HW2, the protostar believed to power one of the outflows observed in this star-forming region. A correlation between the column density distributions of CO2 and water ice with that of total hydrogen indicates that the solid state features we mapped mostly arise from the same molecular clumps along the probed sight lines. We therefore derive average CO2 ice and water ice abundances with respect to the total hydrogen column density of X(CO2)_ice~1.9x10^-5 and X(H2O)_ice~7.5x10^-5. Within errors, the abundances for both ices are relatively constant over the mapped region exhibiting both ice absorptions. The fraction of CO2 ice with respect to H2O ice is also relatively constant at a value of 22% over that mapped region. A clear triple-peaked structure is seen in the CO2 ice profiles. Fits to those profiles using current laboratory ice analogs suggest the presence of both a low-temperature polar ice mixture and a high-temperature methanol-rich ice mixture along the probed sightlines. Our results further indicate that thermal processing of these ices occurred throughout the sampled region.Comment: 26 pages, 8 figures, accepted for publication in Ap