Peri-Prostatic Adipocyte-Released TGFβ Enhances Prostate Cancer Cell Motility by Upregulation of Connective Tissue Growth Factor

Periprostatic adipose tissue (PPAT) has emerged as a key player in the prostate cancer (PCa) microenvironment. In this study, we evaluated the ability of PPAT to promote PCa cell migration, as well as the molecular mechanisms involved. Methods: We collected conditioned mediums from in vitro differentiated adipocytes isolated from PPAT taken from PCa patients during radical prostatectomy. Migration was studied by scratch assay. Results: Culture with CM of human PPAT (AdipoCM) promotes migration in two different human androgen-independent (AI) PCa cell lines (DU145 and PC3) and upregulated the expression of CTGF. SB431542, a well-known TGFβ receptor inhibitor, counteracts the increased migration observed in presence of AdipoCM and decreased CTGF expression, suggesting that a paracrine secretion of TGFβ by PPAT affects motility of PCa cells. Conclusions: Collectively, our study showed that factors secreted by PPAT enhanced migration through CTGF upregulation in AI PCa cell lines. These findings reveal the potential of novel therapeutic strategies targeting adipocyte-released factors and TGFβ/CTGF axis to fight advanced PCa dissemination

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

gCube 4.6.1 - Excel generator library v. 1.0.0

The gCube System - Excel generator library -------------------------------------------------- Generates excel files according to the input. This software is part of the gCube Framework (https://www.gcube-system.org/): an open-source software toolkit used for building and operating Hybrid Data Infrastructures enabling the dynamic deployment of Virtual Research Environments by favouring the realisation of reuse oriented policies. The projects leading to this software have received funding from a series of European Union programmes including: * the Sixth Framework Programme for Research and Technological Development - DILIGENT (grant no. 004260); * the Seventh Framework Programme for research, technological development and demonstration - D4Science (grant no. 212488), D4Science-II (grant no. 239019),ENVRI (grant no. 283465), EUBrazilOpenBio (grant no. 288754), iMarine (grant no. 283644); * the H2020 research and innovation programme - BlueBRIDGE (grant no. 675680), EGIEngage (grant no. 654142), ENVRIplus (grant no. 654182), Parthenos (grant no. 654119), SoBigData (grant no. 654024); Version -------------------------------------------------- 1.0.0-4.6.1-151216 (2017-09-19) Please see the file named "changelog.xml" in this directory for the release notes. Authors -------------------------------------------------- * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A.. Maintainers ----------- * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A.. Download information -------------------------------------------------- Source code is available from SVN: https://svn.research-infrastructures.eu/public/d4science/gcube/trunk/data-analysis/excel-generator/ Binaries can be downloaded from the gCube website: https://www.gcube-system.org/ Installation -------------------------------------------------- Installation and usage example https://wiki.gcube-system.org/gcube/index.php/Tabular_Data_Service Documentation -------------------------------------------------- All needed information are available in Installation page Support -------------------------------------------------- Bugs and support requests can be reported in the gCube issue tracking tool: https://support.d4science.org/projects/gcube/ Licensing -------------------------------------------------- This software is licensed under the terms you may find in the file named "LICENSE" in this directory

gCube 4.7.1 - Excel generator library v. 1.0.0

<p> The gCube System - Excel generator library<br> --------------------------------------------------<br> <br> Generates excel files according to the input.<br> <br> <br> This software is part of the gCube Framework (https://www.gcube-system.org/): an<br> open-source software toolkit used for building and operating Hybrid Data<br> Infrastructures enabling the dynamic deployment of Virtual Research Environments<br> by favouring the realisation of reuse oriented policies.<br> <br> The projects leading to this software have received funding from a series of<br> European Union programmes including:<br> * the Sixth Framework Programme for Research and Technological Development -<br> DILIGENT (grant no. 004260);<br> * the Seventh Framework Programme for research, technological development and<br> demonstration - D4Science (grant no. 212488), D4Science-II (grant no.<br> 239019),ENVRI (grant no. 283465), EUBrazilOpenBio (grant no. 288754), iMarine<br> (grant no. 283644);<br> * the H2020 research and innovation programme - BlueBRIDGE (grant no. 675680),<br> EGIEngage (grant no. 654142), ENVRIplus (grant no. 654182), Parthenos (grant<br> no. 654119), SoBigData (grant no. 654024);<br> <br> <br> Version<br> --------------------------------------------------<br> <br> 1.0.0-4.7.1-151216 (2017-10-19)<br> <br> Please see the file named "changelog.xml" in this directory for the release notes.<br> <br> <br> <br> Authors<br> --------------------------------------------------<br> <br> * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A..<br> <br> <br> Maintainers<br> -----------<br> <br> * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A..<br> <br> Download information<br> --------------------------------------------------<br> <br> Source code is available from SVN: <br> https://svn.research-infrastructures.eu/public/d4science/gcube/trunk/data-analysis/excel-generator/<br> <br> Binaries can be downloaded from the gCube website: <br> https://www.gcube-system.org/<br> <br> <br> Installation<br> --------------------------------------------------<br> <br> Installation and usage example<br> https://wiki.gcube-system.org/gcube/index.php/Tabular_Data_Service <br> <br> Documentation <br> --------------------------------------------------<br> <br> All needed information are available in Installation page <br> <br> Support <br> --------------------------------------------------<br> <br> Bugs and support requests can be reported in the gCube issue tracking tool:<br> https://support.d4science.org/projects/gcube/<br> <br> <br> Licensing<br> --------------------------------------------------<br> <br> This software is licensed under the terms you may find in the file named "LICENSE" in this directory.<br> <br> </p

gCube 4.1.1 - Usermanagement Ws v. 1.0.2

<p> The gCube System - UserManagement-ws<br> --------------------------------------------------<br> <br> SOAP Service to use the usermanagement service<br> <br> <br> This software is part of the gCube Framework (https://www.gcube-system.org/): an<br> open-source software toolkit used for building and operating Hybrid Data<br> Infrastructures enabling the dynamic deployment of Virtual Research Environments<br> by favouring the realisation of reuse oriented policies.<br> <br> The projects leading to this software have received funding from a series of <br> European Union programmes including: <br> * the Sixth Framework Programme for Research and Technological Development - <br> DILIGENT (grant no. 004260); <br> * the Seventh Framework Programme for research, technological development and <br> demonstration - D4Science (grant no. 212488), D4Science-II (grant no. <br> 239019),ENVRI (grant no. 283465), EUBrazilOpenBio (grant no. 288754), iMarine <br> (grant no. 283644); <br> * the H2020 research and innovation programme - BlueBRIDGE (grant no. 675680), <br> EGIEngage (grant no. 654142), ENVRIplus (grant no. 654182), Parthenos (grant <br> no. 654119), SoBigData (grant no. 654024);<br> <br> <br> Version<br> --------------------------------------------------<br> <br> 1.0.2-4.1.1-126559 (2016-12-16)<br> <br> Please see the file named "changelog.xml" in this directory for the release notes.<br> <br> <br> Authors<br> --------------------------------------------------<br> <br> * Kanchanna Ramasamy Balraj (Kanchanna.RamasamyBalraj-AT-eng.it), ENG, Engineering Ingegneria Informatica S.p.A.<br> <br> * Giulio Galiero (Giulio.Galiero-AT-eng.it), ENG, Engineering Ingegneria Informatica S.p.A.<br> <br> * Ciro Formisano (Ciro.Formisano-AT-eng.it), ENG, Engineering Ingegneria Informatica S.p.A.<br> <br> Maintainers<br> -----------------<br> <br> * Ciro Formisano (Ciro.Formisano-AT-eng.it), ENG, Engineering Ingegneria Informatica S.p.A.<br> *Costantino Perciante (costantino.perciante-AT-isti.cnr.it)<br> <br> Download information<br> --------------------------------------------------<br> <br> Source code is available from SVN: <br> http://svn.research-infrastructures.eu/public/d4science/gcube/trunk/vo-management/SOA3/Connector/UserManagement-ws<br> <br> Binaries can be downloaded from the gCube website: <br> https://www.gcube-system.org/<br> <br> <br> Installation<br> --------------------------------------------------<br> <br> Installation documentation is available on-line in the gCube Wiki:<br> https://wiki.gcube-system.org/gcube/index.php<br> <br> Documentation <br> --------------------------------------------------<br> <br> Documentation is available on-line in the gCube Wiki:<br> <br> https://wiki.gcube-system.org/gcube/index.php<br> <br> Support <br> --------------------------------------------------<br> <br> Bugs and support requests can be reported in the gCube issue tracking tool:<br> https://support.d4science.org/projects/gcube/<br> <br> <br> Licensing<br> --------------------------------------------------<br> <br> This software is licensed under the terms you may find in the file named "LICENSE" in this directory.<br> </p

gCube 4.6.0 - HTTPS Proxy portlet v. 2.0.0

<p> The gCube System - HTTPS Proxy portlet<br> --------------------------------------------------<br> <br> Proxy for HTTP based services<br> <br> <br> This software is part of the gCube Framework (https://www.gcube-system.org/): an<br> open-source software toolkit used for building and operating Hybrid Data<br> Infrastructures enabling the dynamic deployment of Virtual Research Environments<br> by favouring the realisation of reuse oriented policies.<br> <br> The projects leading to this software have received funding from a series of<br> European Union programmes including:<br> * the Sixth Framework Programme for Research and Technological Development -<br> DILIGENT (grant no. 004260);<br> * the Seventh Framework Programme for research, technological development and<br> demonstration - D4Science (grant no. 212488), D4Science-II (grant no.<br> 239019),ENVRI (grant no. 283465), EUBrazilOpenBio (grant no. 288754), iMarine<br> (grant no. 283644);<br> * the H2020 research and innovation programme - BlueBRIDGE (grant no. 675680),<br> EGIEngage (grant no. 654142), ENVRIplus (grant no. 654182), Parthenos (grant<br> no. 654119), SoBigData (grant no. 654024);<br> <br> <br> Version<br> --------------------------------------------------<br> <br> 2.0.0-4.6.0-147105 (2017-07-31)<br> <br> Please see the file named "changelog.xml" in this directory for the release notes.<br> <br> <br> <br> Authors<br> --------------------------------------------------<br> <br> * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A..<br> <br> <br> Maintainers<br> -----------<br> <br> * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A..<br> <br> Download information<br> --------------------------------------------------<br> <br> Source code is available from SVN: <br> https://svn.research-infrastructures.eu/public/d4science/gcube/trunk/data-access/gcube-http-proxy<br> <br> Binaries can be downloaded from the gCube website: <br> https://www.gcube-system.org/<br> <br> <br> Installation<br> --------------------------------------------------<br> <br> Installation and usage example<br> https://wiki.gcube-system.org/gcube/index.php/Secure_Proxy_Installation <br> <br> Documentation <br> --------------------------------------------------<br> <br> All needed information are available in Installation page <br> <br> Support <br> --------------------------------------------------<br> <br> Bugs and support requests can be reported in the gCube issue tracking tool:<br> https://support.d4science.org/projects/gcube/<br> <br> <br> Licensing<br> --------------------------------------------------<br> <br> This software is licensed under the terms you may find in the file named "LICENSE" in this directory.<br> <br> </p

Procedure for the certification of spacecraft sensors: An Italian LME success history

The hystory of how an Italian Little Enterprise designed and certified a special product as a sensor and its electronic control system for spacecraft vehicle will be shown. The way to reach the final objective will be related describing the single steps followed

gCube 4.7.0 - Excel generator library v. 1.0.0

<p> The gCube System - Excel generator library<br> --------------------------------------------------<br> <br> Generates excel files according to the input.<br> <br> <br> This software is part of the gCube Framework (https://www.gcube-system.org/): an<br> open-source software toolkit used for building and operating Hybrid Data<br> Infrastructures enabling the dynamic deployment of Virtual Research Environments<br> by favouring the realisation of reuse oriented policies.<br> <br> The projects leading to this software have received funding from a series of<br> European Union programmes including:<br> * the Sixth Framework Programme for Research and Technological Development -<br> DILIGENT (grant no. 004260);<br> * the Seventh Framework Programme for research, technological development and<br> demonstration - D4Science (grant no. 212488), D4Science-II (grant no.<br> 239019),ENVRI (grant no. 283465), EUBrazilOpenBio (grant no. 288754), iMarine<br> (grant no. 283644);<br> * the H2020 research and innovation programme - BlueBRIDGE (grant no. 675680),<br> EGIEngage (grant no. 654142), ENVRIplus (grant no. 654182), Parthenos (grant<br> no. 654119), SoBigData (grant no. 654024);<br> <br> <br> Version<br> --------------------------------------------------<br> <br> 1.0.0-4.7.0-151216 (2017-10-13)<br> <br> Please see the file named "changelog.xml" in this directory for the release notes.<br> <br> <br> <br> Authors<br> --------------------------------------------------<br> <br> * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A..<br> <br> <br> Maintainers<br> -----------<br> <br> * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A..<br> <br> Download information<br> --------------------------------------------------<br> <br> Source code is available from SVN: <br> https://svn.research-infrastructures.eu/public/d4science/gcube/trunk/data-analysis/excel-generator/<br> <br> Binaries can be downloaded from the gCube website: <br> https://www.gcube-system.org/<br> <br> <br> Installation<br> --------------------------------------------------<br> <br> Installation and usage example<br> https://wiki.gcube-system.org/gcube/index.php/Tabular_Data_Service <br> <br> Documentation <br> --------------------------------------------------<br> <br> All needed information are available in Installation page <br> <br> Support <br> --------------------------------------------------<br> <br> Bugs and support requests can be reported in the gCube issue tracking tool:<br> https://support.d4science.org/projects/gcube/<br> <br> <br> Licensing<br> --------------------------------------------------<br> <br> This software is licensed under the terms you may find in the file named "LICENSE" in this directory.<br> <br> </p

gCube 4.7.0 - Tabular data model v. 3.4.0

The gCube System - Tabular data model -------------------------------------------------- Tabular Data resource model This software is part of the gCube Framework (https://www.gcube-system.org/): an open-source software toolkit used for building and operating Hybrid Data Infrastructures enabling the dynamic deployment of Virtual Research Environments by favouring the realisation of reuse oriented policies. The projects leading to this software have received funding from a series of European Union programmes including: * the Sixth Framework Programme for Research and Technological Development - DILIGENT (grant no. 004260); * the Seventh Framework Programme for research, technological development and demonstration - D4Science (grant no. 212488), D4Science-II (grant no. 239019),ENVRI (grant no. 283465), EUBrazilOpenBio (grant no. 288754), iMarine (grant no. 283644); * the H2020 research and innovation programme - BlueBRIDGE (grant no. 675680), EGIEngage (grant no. 654142), ENVRIplus (grant no. 654182), Parthenos (grant no. 654119), SoBigData (grant no. 654024); Version -------------------------------------------------- 3.4.0-4.7.0-152975 (2017-10-13) Please see the file named "changelog.xml" in this directory for the release notes. Authors -------------------------------------------------- * Fabio Sinibaldi (fabio.sinibaldi-AT-isti.cnr.it) Istituto di Scienza e Tecnologie dell'Informazione "A. Faedo" - CNR, Pisa (Italy). * Lucio Lelii (lucio.lelii-AT-isti.cnr.it) Istituto di Scienza e Tecnologie dell'Informazione "A. Faedo" - CNR, Pisa (Italy). * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A.. Maintainers ----------- * Fabio Sinibaldi (fabio.sinibaldi-AT-isti.cnr.it) Istituto di Scienza e Tecnologie dell'Informazione "A. Faedo" - CNR, Pisa (Italy). * Lucio Lelii (lucio.lelii-AT-isti.cnr.it) Istituto di Scienza e Tecnologie dell'Informazione "A. Faedo" - CNR, Pisa (Italy). * Ciro Formisano ([email protected]), ENG, Roma, Engineering Ingegneria Informatica S.p.A.. Download information -------------------------------------------------- Source code is available from SVN: https://svn.research-infrastructures.eu/public/d4science/gcube/trunk/data-analysis/tabulardata/tabular-model Binaries can be downloaded from the gCube website: https://www.gcube-system.org/ Installation -------------------------------------------------- Installation documentation is available on-line in the gCube Wiki: https://wiki.gcube-system.org/gcube/index.php/Tabular_Data_Manager Documentation -------------------------------------------------- Documentation is available on-line in the gCube Wiki: https://wiki.gcube-system.org/gcube/index.php/Tabular_Data_Manager https://wiki.gcube-system.org/gcube/index.php/Tabular_Data_Manager Support -------------------------------------------------- Bugs and support requests can be reported in the gCube issue tracking tool: https://support.d4science.org/projects/gcube/ Licensing -------------------------------------------------- This software is licensed under the terms you may find in the file named "LICENSE" in this directory