287 research outputs found
Case report: Personalized transcatheter approach to mid-aortic syndrome by in vitro simulation on a 3-dimensional printed model
An 8-year-old girl, diagnosed with mid-aortic syndrome (MAS) at the age of 2 months and under antihypertensive therapy, presented with severe systemic hypertension (>200/120 mmHg). Computed tomography (CT) examination revealed aortic aneurysm between severe stenoses at pre- and infra-renal segments, and occlusion of principal splanchnic arteries with peripheral collateral revascularization. Based on CT imaging, preoperative three-dimensional (3D) anatomy was reconstructed to assess aortic dimensions and a dedicated in vitro planning platform was designed to investigate the feasibility of a stenting procedure under fluoroscopic guidance. The in vitro system was designed to incorporate a translucent flexible 3D-printed patient-specific model filled with saline. A covered 8-zig 45-mm-long Cheatham-Platinum (CP) stent and a bare 8-zig, 34-mm-long CP stent were implanted with partial overlap to treat the stenoses (global peak-to-peak pressure gradient > 60 mmHg), excluding the aneurysm and avoiding risk of renal arteries occlusion. Percutaneous procedure was successfully performed with no residual pressure gradient and exactly replicating the strategy tested in vitro. Also, as investigated on the 3D-printed model, additional angioplasty was feasible across the frames of the stent to improve bilateral renal flow. Postoperative systemic pressure significantly reduced (130/70 mmHg) as well as dosage of antihypertensive therapy. This is the first report demonstrating the use of a 3D-printed model to effectively plan percutaneous intervention in a complex pediatric MAS case: taking full advantage of the combined use of a patient-specific 3D model and a dedicated in vitro platform, feasibility of the stenting procedure was successfully tested during pre-procedural assessment. Hence, use of patient-specific 3D-printed models and in vitro dedicated platforms is encouraged to assist pre-procedural planning and personalize treatment, thus enhancing intervention success
A liver angioma colonized by colon cancer cells in a patient with two primitive localizations by colon adenocarcinoma: biologic, diagnostic and therapeutic implications
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Vulnerability analysis of satellite-based synchronized smart grids monitoring systems
The large-scale deployment of wide-area monitoring systems could play a strategic role in supporting the evolution of traditional power systems toward smarter and self-healing grids. The correct operation of these synchronized monitoring systems requires a common and accurate timing reference usually provided by a satellite-based global positioning system. Although these satellites signals provide timing accuracy that easily exceeds the needs of the power industry, they are extremely vulnerable to radio frequency interference. Consequently, a comprehensive analysis aimed at identifying their potential vulnerabilities is of paramount importance for correct and safe wide-area monitoring system operation. Armed with such a vision, this article presents and discusses the results of an experimental analysis aimed at characterizing the vulnerability of global positioning system based wide-area monitoring systems to external interferences. The article outlines the potential strategies that could be adopted to protect global positioning system receivers from external cyber-attacks and proposes decentralized defense strategies based on self-organizing sensor networks aimed at assuring correct time synchronization in the presence of external attacks
PAMELA's measurements of geomagnetic cutoff variations during solar energetic particle events
Data from the PAMELA satellite experiment were used to measure the
geomagnetic cutoff for high-energy ( 80 MeV) protons during the solar
particle events on 2006 December 13 and 14. The variations of the cutoff
latitude as a function of rigidity were studied on relatively short timescales,
corresponding to single spacecraft orbits (about 94 minutes). Estimated cutoff
values were cross-checked with those obtained by means of a trajectory tracing
approach based on dynamical empirical modeling of the Earth's magnetosphere. We
find significant variations in the cutoff latitude, with a maximum suppression
of about 6 deg for 80 MeV protons during the main phase of the storm. The
observed reduction in the geomagnetic shielding and its temporal evolution were
compared with the changes in the magnetosphere configuration, investigating the
role of IMF, solar wind and geomagnetic (Kp, Dst and Sym-H indexes) variables
and their correlation with PAMELA cutoff results.Comment: Conference: The 34th International Cosmic Ray Conference (ICRC2015),
30 July - 6 August, 2015, The Hague, The Netherlands, Volume:
PoS(ICRC2015)28
Time dependence of the e^- flux measured by PAMELA during the July 2006 - December 2009 solar minimum
Precision measurements of the electron component in the cosmic radiation
provide important information about the origin and propagation of cosmic rays
in the Galaxy not accessible from the study of the cosmic-ray nuclear
components due to their differing diffusion and energy-loss processes. However,
when measured near Earth, the effects of propagation and modulation of galactic
cosmic rays in the heliosphere, particularly significant for energies up to at
least 30 GeV, must be properly taken into account. In this paper the electron
(e^-) spectra measured by PAMELA down to 70 MeV from July 2006 to December 2009
over six-months time intervals are presented. Fluxes are compared with a
state-of-the-art three-dimensional model of solar modulation that reproduces
the observations remarkably well.Comment: 40 pages, 18 figures, 1 tabl
Solar energetic particle events: trajectory analysis and flux reconstruction with PAMELA
The PAMELA satellite experiment is providing first direct measurements of
Solar Energetic Particles (SEPs) with energies from about 80 MeV to several GeV
in near-Earth space, bridging the low energy data by other space-based
instruments and the Ground Level Enhancement (GLE) data by the worldwide
network of neutron monitors. Its unique observational capabilities include the
possibility of measuring the flux angular distribution and thus investigating
possible anisotropies. This work reports the analysis methods developed to
estimate the SEP energy spectra as a function of the particle pitch-angle with
respect to the Interplanetary Magnetic Field (IMF) direction. The crucial
ingredient is provided by an accurate simulation of the asymptotic exposition
of the PAMELA apparatus, based on a realistic reconstruction of particle
trajectories in the Earth's magnetosphere. As case study, the results for the
May 17, 2012 event are presented.Comment: Conference: The 34th International Cosmic Ray Conference (ICRC2015),
30 July - 6 August, 2015, The Hague, The Netherlands, Volume:
PoS(ICRC2015)08
Time dependence of the proton flux measured by PAMELA during the July 2006 - December 2009 solar minimum
The energy spectra of galactic cosmic rays carry fundamental information
regarding their origin and propagation. These spectra, when measured near
Earth, are significantly affected by the solar magnetic field. A comprehensive
description of the cosmic radiation must therefore include the transport and
modulation of cosmic rays inside the heliosphere. During the end of the last
decade the Sun underwent a peculiarly long quiet phase well suited to study
modulation processes. In this paper we present proton spectra measured from
July 2006 to December 2009 by PAMELA. The large collected statistics of protons
allowed the time variation to be followed on a nearly monthly basis down to 400
MV. Data are compared with a state-of-the-art three-dimensional model of solar
modulation.Comment: 17 pages, 5 figures, 1 table, to appear in Astrophysical Journal.
Corrected two elements of Table
Search for anisotropies in cosmic-ray positrons detected by the PAMELA experiment
The PAMELA detector was launched on board of the Russian Resurs-DK1 satellite
on June 15, 2006. Data collected during the first four years have been used to
search for large-scale anisotropies in the arrival directions of cosmic-ray
positrons. The PAMELA experiment allows for a full sky investigation, with
sensitivity to global anisotropies in any angular window of the celestial
sphere. Data samples of positrons in the rigidity range 10 GV R
200 GV were analyzed. This article discusses the method and the results of the
search for possible local sources through analysis of anisotropy in positron
data compared to the proton background. The resulting distributions of arrival
directions are found to be isotropic. Starting from the angular power spectrum,
a dipole anisotropy upper limit \delta = 0.166 at 95% C.L. is determined.
Additional search is carried out around the Sun. No evidence of an excess
correlated with that direction was found.Comment: The value of the dipole anisotropy upper limit has been changed. The
method is correct but there was a miscalculation in the relative formul
Measurement of boron and carbon fluxes in cosmic rays with the PAMELA experiment
The propagation of cosmic rays inside our galaxy plays a fundamental role in
shaping their injection spectra into those observed at Earth. One of the best
tools to investigate this issue is the ratio of fluxes for secondary and
primary species. The boron-to-carbon (B/C) ratio, in particular, is a sensitive
probe to investigate propagation mechanisms. This paper presents new
measurements of the absolute fluxes of boron and carbon nuclei, as well as the
B/C ratio, from the PAMELA space experiment. The results span the range 0.44 -
129 GeV/n in kinetic energy for data taken in the period July 2006 - March
2008
Trapped proton fluxes at low Earth orbits measured by the PAMELA experiment
We report an accurate measurement of the geomagnetically trapped proton
fluxes for kinetic energy above > 70 MeV performed by the PAMELA mission at low
Earth orbits (350-610 km). Data were analyzed in the frame of the adiabatic
theory of charged particle motion in the geomagnetic field. Flux properties
were investigated in detail, providing a full characterization of the particle
radiation in the South Atlantic Anomaly region, including locations, energy
spectra and pitch angle distributions. PAMELA results significantly improve the
description of the Earth's radiation environment at low altitudes placing
important constraints on the trapping and interaction processes, and can be
used to validate current trapped particle radiation models.Comment: 22 pages, 5 figure
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