3,216 research outputs found
Multi-scale Renormalisation Group Improvement of the Effective Potential
Using the renormalisation group and a conjecture concerning the perturbation
series for the effective potential, the leading logarithms in the effective
potential are exactly summed for scalar and Yukawa theories.Comment: 19 pages, DIAS STP 94-09. Expanded to check large N limit, typo's
corrected, to appear in Phys Rev
Probability distributions of smeared quantum stress tensors
We obtain in closed form the probability distribution for individual
measurements of the stress-energy tensor of two-dimensional conformal field
theory in the vacuum state, smeared in time against a Gaussian test function.
The result is a shifted Gamma distribution with the shift given by the
previously known optimal quantum inequality bound. For small values of the
central charge it is overwhelmingly likely that individual measurements of the
sampled energy density in the vacuum give negative results. For the case of a
single massless scalar field, the probability of finding a negative value is
84%. We also report on computations for four-dimensional massless scalar fields
showing that the probability distribution of the smeared square field is also a
shifted Gamma distribution, but that the distribution of the energy density is
not.Comment: 9 pages, 1 figure. Minor edits implemente
On wormholes with arbitrarily small quantities of exotic matter
Recently several models of traversable wormholes have been proposed which
require only arbitrarily small amounts of negative energy to hold them open
against self-collapse. If the exotic matter is assumed to be provided by
quantum fields, then quantum inequalities can be used to place constraints on
the negative energy densities required. In this paper, we introduce an
alternative method for obtaining constraints on wormhole geometries, using a
recently derived quantum inequality bound on the null-contracted stress-energy
averaged over a timelike worldline. The bound allows us to perform a simplified
analysis of general wormhole models, not just those with small quantities of
exotic matter. We then use it to study, in particular, the models of Visser,
Kar, and Dadhich (VKD) and the models of Kuhfittig. The VKD models are
constrained to be either submicroscopic or to have a large discrepancy between
throat size and curvature radius. A recent model of Kuhfittig is shown to be
non-traversable. This is due to the fact that the throat of his wormhole flares
outward so slowly that light rays and particles, starting from outside the
throat, require an infinite lapse of affine parameter to reach the throat.Comment: 30 pages, 2 figure
Quantum inequalities and `quantum interest' as eigenvalue problems
Quantum inequalities (QI's) provide lower bounds on the averaged energy
density of a quantum field. We show how the QI's for massless scalar fields in
even dimensional Minkowski space may be reformulated in terms of the positivity
of a certain self-adjoint operator - a generalised Schroedinger operator with
the energy density as the potential - and hence as an eigenvalue problem. We
use this idea to verify that the energy density produced by a moving mirror in
two dimensions is compatible with the QI's for a large class of mirror
trajectories. In addition, we apply this viewpoint to the `quantum interest
conjecture' of Ford and Roman, which asserts that the positive part of an
energy density always overcompensates for any negative components. For various
simple models in two and four dimensions we obtain the best possible bounds on
the `quantum interest rate' and on the maximum delay between a negative pulse
and a compensating positive pulse. Perhaps surprisingly, we find that - in four
dimensions - it is impossible for a positive delta-function pulse of any
magnitude to compensate for a negative delta-function pulse, no matter how
close together they occur.Comment: 18 pages, RevTeX. One new result added; typos fixed. To appear in
Phys. Rev.
Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes
Diets rich in fruits and vegetables (FV), which contain (poly)phenols, protect against age-related inflammation and chronic diseases. T-lymphocytes contribute to systemic cytokine production and are modulated by FV intake. Little is known about the relative potency of different (poly)phenols in modulating cytokine release by lymphocytes. We compared thirty-one (poly)phenols and six (poly)phenol mixtures for effects on pro-inflammatory cytokine release by Jurkat T-lymphocytes. Test compounds were incubated with Jurkat cells for 48 h at 1 and 30 µm, with or without phorbol ester treatment at 24 h to induce cytokine release. Three test compounds that reduced cytokine release were further incubated with primary lymphocytes at 0·2 and 1 µm for 24 h, with lipopolysaccharide added at 5 h. Cytokine release was measured, and generation of H2O2 by test compounds was determined to assess any potential correlations with cytokine release. A number of (poly)phenols significantly altered cytokine release from Jurkat cells (P<0·05), but H2O2 generation did not correlate with cytokine release. Resveratrol, isorhamnetin, curcumin, vanillic acid and specific (poly)phenol mixtures reduced pro-inflammatory cytokine release from T-lymphocytes, and there was evidence for interaction between (poly)phenols to further modulate cytokine release. The release of interferon-γ induced protein 10 by primary lymphocytes was significantly reduced following treatment with 1 µm isorhamnetin (P<0·05). These results suggest that (poly)phenols derived from onions, turmeric, red grapes, green tea and açai berries may help reduce the release of pro-inflammatory mediators in people at risk of chronic inflammation
Probability distributions for quantum stress tensors in four dimensions
We treat the probability distributions for quadratic quantum fields, averaged
with a Lorentzian test function, in four-dimensional Minkowski vacuum. These
distributions share some properties with previous results in two-dimensional
spacetime. Specifically, there is a lower bound at a finite negative value, but
no upper bound. Thus arbitrarily large positive energy density fluctuations are
possible. We are not able to give closed form expressions for the probability
distribution, but rather use calculations of a finite number of moments to
estimate the lower bounds, the asymptotic forms for large positive argument,
and possible fits to the intermediate region. The first 65 moments are used for
these purposes. All of our results are subject to the caveat that these
distributions are not uniquely determined by the moments. However, we also give
bounds on the cumulative distribution function that are valid for any
distribution fitting these moments.We apply the asymptotic form of the
electromagnetic energy density distribution to estimate the nucleation rates of
black holes and of Boltzmann brains.Comment: 26 pages, 2 figure
A Search for Exozodiacal Clouds with Kepler
Planets embedded within dust disks may drive the formation of large scale
clumpy dust structures by trapping dust into resonant orbits. Detection and
subsequent modeling of the dust structures would help constrain the mass and
orbit of the planet and the disk architecture, give clues to the history of the
planetary system, and provide a statistical estimate of disk asymmetry for
future exoEarth-imaging missions. Here we present the first search for these
resonant structures in the inner regions of planetary systems by analyzing the
light curves of hot Jupiter planetary candidates identified by the Kepler
mission. We detect only one candidate disk structure associated with KOI 838.01
at the 3-sigma confidence level, but subsequent radial velocity measurements
reveal that KOI 838.01 is a grazing eclipsing binary and the candidate disk
structure is a false positive. Using our null result, we place an upper limit
on the frequency of dense exozodi structures created by hot Jupiters. We find
that at the 90% confidence level, less than 21% of Kepler hot Jupiters create
resonant dust clumps that lead and trail the planet by ~90 degrees with optical
depths >~5*10^-6, which corresponds to the resonant structure expected for a
lone hot Jupiter perturbing a dynamically cold dust disk 50 times as dense as
the zodiacal cloud.Comment: 22 pages, 6 figures, Accepted for publication in Ap
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Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing
Over 30% of the world’s population is infected with Mycobacterium tuberculosis (Mtb), yet only ~5–10% will develop clinical disease1. Despite considerable effort, we understand little about what distinguishes individuals who progress to active tuberculosis (TB) from those who remain latent for decades. The variable course of disease is recapitulated in cynomolgus macaques infected with Mtb2. Active disease in macaques is defined by clinical, microbiologic and immunologic signs and occurs in ~45% of animals, while the remaining are clinically asymptomatic2,3. Here, we use barcoded Mtb isolates and quantitative measures of culturable and cumulative bacterial burden to show that most lesions are likely founded by a single bacterium and reach similar maximum burdens. Despite common origins, the fate of individual lesions varies substantially within the same host. Strikingly, in active disease, the host sterilizes some lesions even while others progress. Our data suggest that lesional heterogeneity arises, in part, through differential killing of bacteria after the onset of adaptive immunity. Thus, individual lesions follow diverse and overlapping trajectories, suggesting critical responses occur at a lesional level to ultimately determine the clinical outcome of infection. Defining the local factors that dictate outcome will be important in developing effective interventions to prevent active TB
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