An Ethics of Discomfort: Supplementing Ricoeur on Translation

This article compares Paul Ricoeur and Jacques Derrida on the theme of translation and in particular the ethical implications of the different ways in which they approach the untranslatable.  While Ricoeur’s account of translation as linguistic hospitality does offer a model for an ethical encounter with the other, I argue that this account does not go far enough. My central claim is that Ricoeur’s treatment of translation overemphasizes the movement of appropriation and integration.  While it may not be his intention, this emphasis could lead to a certain kind of complacency that would challenge the ethical claims Ricoeur makes in favour of translation as a paradigm.  I propose to supplement Ricoeur’s hospitality with Derrida’s untranslatable, in order to create a situation of constant discomfort thereby guarding against ethical complacency.Cet article compare les approches que Ricœur et Derida font du thème de la traduction en abordant en particulier les implications éthiques de leurs manières différentes d’aborder la question de l’intraduisible. Si le traitement ricœurien du problème de la traduction en termes d’hospitalité langagière offre le modèle d’une rencontre éthique de l’autre, je soutiens que cette approche ne va pas assez loin. Mon argument central est que, dans son traitement de la traduction, Ricœur met exagérément l’accent sur le mouvement d’appropriation et d’intégration. Même si cette emphase n’est peut-être pas intentionnelle, elle pourrait conduire à une certaine suffisance susceptible de remettre en question le pladoyer éthique de Ricœur en faveur de la traduction comme paradigme. Je propose en ce sens d’ajouter à l’hospitalité ricœurienne l’intraduisible derridien, afin de créer une situation de constant inconfort nous préservant de toute suffisance éthique

Neuroprotective Activity of Leukemia Inhibitory Factor Is Relayed through Myeloid Zinc Finger-1 in a Rat Model of Stroke

The aim of this study was to determine whether leukemia inhibitory factor (LIF) exerts its neuroprotective effects through signal transduction of the transcription factor myeloid zinc finger-1 (MZF-1). According to the hypothesis of this study, MZF-1 mediates LIF-induced neuroprotective signaling during ELVO through increased expression and transcriptional activity. To determine the in vivo role of MZF-1 in LIF-induced neuroprotection, we used Genomatix software was used to MZF-1 sites in the promoter region of the rat superoxide dismutase 3 (SOD3) gene. Stroke was induced via middle cerebral artery occlusion, and animals were administered PBS or 125 μg/kg LIF at 6, 24, and 48 h after the injury. MZF-1 binding activity was measured using electrophoretic mobility shift assay (EMSA) and its expression/localization were determined using western blot and immunohistochemical analysis. To determine whether MZF-1 relays LIF-induced neuroprotection in vitro, primary cultured neurons were subjected to oxygen-glucose deprivation (OGD) after treatment with PBS or LIF. MZF-1 expression was measured in vitro using real time PCR and immunohistochemical staining. Transfection with siRNA was used to determine whether LIF protected cultured neurons against OGD after silencing MZF-1 expression. Four MZF-1 binding sites were identified by Genomatix, and EMSA confirmed in vivo binding activity in brain after MCAO. LIF significantly increased MZF-1 protein levels compared to PBS treatment at 72 h post-MCAO. In vivo nuclear localization of MZF-1 as well as co-localization of SOD3 and MZF-1 was observed in the cortical neurons of LIF-treated rats. Primary cultured neurons treated with LIF had significantly higher levels of MZF-1 mRNA and protein after LIF treatment compared to neurons treated with PBS. Finally, knockdown MZF-1 using siRNA counteracted the neuroprotective effects of LIF in vitro. These data demonstrate that LIF-mediated neuroprotection is dependent upon MZF-1 activity. Furthermore, these findings identify a novel neuroprotective pathway that employs MZF-1, a transcription factor associated with hematopoietic gene expression

Plasticity of host selection by malaria vectors of Papua New Guinea

Background Host selection is an important determinant of vectorial capacity because malaria transmission increases when mosquitoes feed more on humans than non-humans. Host selection also affects the outcome of long-lasting insecticidal nets (LLIN). Despite the recent nationwide implementation of LLIN-based malaria control program in Papua New Guinea (PNG), little is known about the host selection of the local Anopheles vectors. This study investigated the host selection of Anopheles vectors in PNG. Methods Blood-engorged mosquitoes were sampled using the barrier screen method and blood meals analyzed for vertebrate host source with PCR-amplification of the mitochondrial cytochrome b gene. Abundance of common hosts was estimated in surveys. The test of homogeneity of proportions and the Manly resource selection ratio were used to determine if hosts were selected in proportion to their abundance. Results Two thousand four hundred and forty blood fed Anopheles females of seven species were sampled from five villages in Madang, PNG. Of 2,142 samples tested, 2,061 (96.2%) yielded a definitive host source; all were human, pig, or dog. Hosts were not selected in proportion to their abundance, but rather were under-selected or over-selected by the mosquitoes. Four species, Anopheles farauti (sensu stricto) (s.s.), Anopheles punctulatus (s.s.), Anopheles farauti no. 4 and Anopheles longirostris, over-selected humans in villages with low LLIN usage, but over-selected pigs in villages with high LLIN usage. Anopheles koliensis consistently over-selected humans despite high LLIN usage, and Anopheles bancroftii over-selected pigs. Conclusions The plasticity of host selection of an Anopheles species depends on its opportunistic, anthropophilic or zoophilic behavior, and on the extent of host availability and LLIN usage where the mosquitoes forage for hosts. The high anthropophily of An. koliensis increases the likelihood of contacting the LLIN inside houses. This allows its population size to be reduced to levels insufficient to support transmission. In contrast, by feeding on alternative hosts the likelihood of the opportunistic species to contact LLIN is lower, making them difficult to control. By maintaining high population size, the proportion that feed on humans outdoors can sustain residual transmission despite high LLIN usage in the village

Translational Evaluation of Acid/Base and Electrolyte Alterations in Rodent Model of Focal Ischemia

BACKGROUND AND PURPOSE: Acid/base and electrolytes could provide clinically valuable information about cerebral infarct core and penumbra. We evaluated associations between acid/base and electrolyte changes and outcomes in 2 rat models of stroke, permanent, and transient middle cerebral artery occlusion. METHODS: Three-month old Sprague-Dawley rats underwent permanent or transient middle cerebral artery occlusion. Pre- and post-middle cerebral artery occlusion venous samples for permanent and transient models provided pH, carbon dioxide, oxygen, glucose, and electrolyte values of ionized calcium, potassium, and sodium. Multiple regression determined predictors of infarct volume from these values, and Kaplan-Meier curve analyzed morality between permanent and transient middle cerebral artery occlusion models. RESULTS: Analysis indicated significant differences in the blood gas and electrolytes between pre- to post-middle cerebral artery occlusion. A decrease in pH and sodium with increases in carbon dioxide, potassium, ionized calcium, and glucose changes were found in both middle cerebral artery occlusion models; while hematocrit and hemoglobin were significant in the transient model. pH and ionized calcium were predictors of infarct volume in the permanent model, as changes in pH and ionized calcium decreased, infarct volume increased. CONCLUSIONS: There are acute changes in acid/base balance and electrolytes during stroke in transient and permanent rodent models. Additionally, we found pH and ionized calcium changes predicted stroke volume in the permanent middle cerebral artery occlusion model. These preliminary findings are novel, and warrant further exploration in human conditions

An Ethics Of Discomfort: Supplementing Ricœur On Translation

This article compares Paul Ricoeur and Jacques Derrida on the theme of translation and in particular the ethical implications of the different ways in which they approach the untranslatable. While Ricoeur’s account of translation as linguistic hospitality does offer a model for an ethical encounter with the other, I argue that this account does not go far enough. My central claim is that Ricoeur’s treatment of translation overemphasizes the movement of appropriation and integration. While it may not be his intention, this emphasis could lead to a certain kind of complacency that would challenge the ethical claims Ricoeur makes in favour of translation as a paradigm. I propose to supplement Ricoeur’s hospitality with Derrida’s untranslatable, in order to create a situation of constant discomfort thereby guarding against ethical complacency

An Ethical Suspension of the Political: Untranslatability with Beauvoir and Cassin

How we name each other sets in motion how we treat each other, each act of naming both opens up a certain mode of engagement and closes off others. When we tell each other our nationality or our political affiliation, our religion or our ethnicity, our gender or our class, and so on; we reveal an aspect of who we are. Sometimes we do this explicitly, at other times we do so implicitly or unintentionally. We each have many aspects and often these sides of who we are affirm our membership of a group – Republicans or Democrats; Catholics or Hindus; male or trans and so on. This group membership may be an integral part of how we understand ourselves and relate to others, or it may be experienced as merely incidental. As Iris Marrion Young has argued, group membership is part of the contemporary human condition that in itself is relatively neutral but is also not simple or exclusive. Rather, group membership is “multiple, cross-cutting, fluid, and shifting […]. In complex, highly differentiated societies like our own, all persons have multiple group identifications.” (Young, 48)Vol/issue details in uploaded article are incorrect. Record details have been ammended to reflect version of record

Untranslatability and the ethics of pause

Untranslatability has been seen as a problematic concept in Translation Studies, rooted in outdated views of translation as doomed to failure. In this paper, I argue against such a view of untranslatability to make two claims. The first is that at least a temporary untranslatability is the condition of translation, without it translation would be redundant. The second is that untranslatability offers us both an ethical and descriptive model for intersubjective relations such that it does not merely refer to a textual practice but also to ways in which we relate to each other as human beings. In the first part of the paper, I engage with two critics of untranslatability–Ricoeur and Venuti–to claim that in their rejection of the untranslatable, they lose something productive. Against a view of the untranslatable as something ‘sacred’, as described by Heidegger; I argue that we might think of the untranslatable as that which exceeds our understanding yet generates the desire to understand at all. Drawing on the work of Derrida, Levinas, and Cassin, I claim that the untranslatable offers us a way of thinking of translation and understanding in general as ethical when they are paused, suspended, or interrupted

A Novel Methodology for the Synchronous Collection and Multimodal Visualization of Continuous Neurocardiovascular and Neuromuscular Physiological Data in Adults with Long COVID

Background: Reports suggest that adults with post-COVID-19 syndrome or long COVID may be affected by orthostatic intolerance syndromes, with autonomic nervous system dysfunction as a possible causal factor of neurocardiovascular instability (NCVI). Long COVID can also manifest as prolonged fatigue, which may be linked to neuromuscular function impairment (NMFI). The current clinical assessment for NCVI monitors neurocardiovascular performance upon the application of orthostatic stressors such as an active (i.e., self-induced) stand or a passive (tilt table) standing test. Lower limb muscle contractions may be important in orthostatic recovery via the skeletal muscle pump. In this study, adults with long COVID were assessed with a protocol that, in addition to the standard NCVI tests, incorporated simultaneous lower limb muscle monitoring for NMFI assessment. Methods: To conduct such an investigation, a wide range of continuous non-invasive biomedical sensing technologies were employed, including digital artery photoplethysmography for the extraction of cardiovascular signals, near-infrared spectroscopy for the extraction of regional tissue oxygenation in brain and muscle, and electromyography for assessment of timed muscle contractions in the lower limbs. Results: With the proposed methodology described and exemplified in this paper, we were able to collect relevant physiological data for the assessment of neurocardiovascular and neuromuscular functioning. We were also able to integrate signals from a variety of instruments in a synchronized fashion and visualize the interactions between different physiological signals during the combined NCVI/NMFI assessment. Multiple counts of evidence were collected, which can capture the dynamics between skeletal muscle contractions and neurocardiovascular responses. Conclusions: The proposed methodology can offer an overview of the functioning of the neurocardiovascular and neuromuscular systems in a combined NCVI/NMFI setup and is capable of conducting comparative studies with signals from multiple participants at any given time in the assessment. This could help clinicians and researchers generate and test hypotheses based on the multimodal inspection of raw data in long COVID and other cohorts