Sex With Animals (swa): Behavioral Characteristics And Possible Association With Penile Cancer. A Multicenter Study

Introduction. Zoophilia has been known for a long time but, underreported in the medical literature, is likely a risk factor for human urological diseases. Aim. To investigate the behavioral characteristics of sex with animals (SWA) and its associations with penile cancer (PC) in a case-control study. Methods. A questionnaire about personal and sexual habits was completed in interviews of 118 PC patients and 374 controls (healthy men) recruited between 2009 and 2010 from 16 urology and oncology centers. Main Outcome Measures. SWA rates, geographic distribution, duration, frequency, animals involved, and behavioral habits were investigated and used to estimate the odds of SWA as a PC risk factor. Results. SWA was reported by 171 (34.8%) subjects, 44.9% of PC patients and 31.6% of controls (P<0.008). The mean ages at first and last SWA episode were 13.5 years (standard deviation [SD] 4.4 years) and 17.1 years (SD 5.3 years), respectively. Subjects who reported SWA also reported more venereal diseases (P<0.001) and sex with prostitutes (P<0.001), and were more likely to have had more than 10 lifetime sexual partners (P<0.001) than those who did not report SWA. SWA with a group of men was reported by 29.8% of subjects and SWA alone was reported by 70.2%. Several animals were used by 62% of subjects, and 38% always used the same animal. The frequency of SWA included single (14%), weekly or more (39.5%), and monthly episodes (15%). Univariate analysis identified phimosis, penile premalignancies, smoking, nonwhite race, sex with prostitutes, and SWA as PC risk factors. Phimosis, premalignant lesions, smoking, and SWA remained as risk factors in multivariate analysis. However, SWA did not impact the clinicopathological outcomes of PC. Conclusion. SWA is a risk factor for PC and may be associated with venereal diseases. New studies are required in other populations to test other possible nosological links with SWA. © 2011 International Society for Sexual Medicine.9718601867Curado, M.P., Edwards, B., Shin, H.R., Storm, H., Ferlay, J., Heanue, M., Boyle, P., (2007) Cancer incidence in five continents, 9. , [IARC Scientific Publications, 160]. Lyon: IARCPow-Sang, M.R., Ferreira, U., Pow-Sang, J.M., Nardi, A.C., Destefano, V., Epidemiology and natural history of penile cancer (2010) Urology, 76 (1), pp. S2-S6. , SUPPLMiralles-Guri, C., Bruni, L., Cubilla, A.L., Castellsagué, X., Bosch, F.X., de Sanjosé, S., Human papillomavirus prevalence and type distribution in penile carcinoma (2009) J Clin Pathol, 62, pp. 870-878Maden, C., Sherman, K.J., Beckmann, A.M., Hislop, T.G., Teh, C.Z., Ashley, R.L., Daling, J.R., History of circumcision, medical conditions, and sexual activity and risk of penile cancer (1993) J Natl Cancer Inst, 85, pp. 19-24Sobin, L.H., Wittekind, C., (2002) TNM classification of malignant tumors, , eds. 6th edition. New York, NY: Wiley & SonsWilliams, C.J., Weinberg, M.S., Zoophilia in men: A study of sexual interest in animals (2003) Arch Sex Behav, 32, pp. 523-535Miletski, H., (2002) Understanding bestiality and zoophilia, p. 273. , Bethesda, MD: East-West Publishing LLCShenken, L.I., Some clinical and psychopathological aspects of bestiality (1964) J Nerv Ment Dis, 139, pp. 137-142Karpman, B., (1954) The sexual offender and his offenses: Etiology, pathology, psychodynamics, and treatment, , New York: Julian PressKinsey, A.C., Pomeroy, W.B., Martin, C.E., (1948) Sexual behavior in the human male, , Philadelphia: W.B. SaundersAlvarez, W.A., Freinhar, J.P., A prevalence study of bestiality (zoophilia) in psychiatric in-patients, medical in-patients and psychiatric staff (1991) Int J Psychosom, 38, pp. 45-47Tseng, H.F., Morgenstern, H., Mack, T., Peters, R.K., Risk factors for penile cancer: Results of a population-based case-control study in Los Angeles County (United States) (2001) Cancer Causes Control, 12, pp. 267-277Daling, J.R., Madeleine, M.M., Johnson, L.G., Schwartz, S.M., Shera, K.A., Wurscher, M.A., Carter, J.J., Krieger, J.N., Penile cancer: Importance of circumcision, human papillomavirus and smoking in in situ and invasive disease (2005) Int J Cancer, 116, pp. 606-616Hellberg, D., Valentin, J., Eklund, T., Nilsson, S., Penile cancer: Is there an epidemiological role for smoking and sexual behaviour? (1987) Br Med J (Clin Res Ed), 295, pp. 1306-1308Wideroff, L., Schottenfield, D., Penile cancer (2006) Cancer epidemiology and prevention, pp. 1166-1172. , Schottenfeld D, Fraumeni JF, eds. New York: Oxford University PressEdlin, R.S., Aaronson, D.S., Wu, A.K., Blaschko, S.D., Yang, G., Erickson, B.A., McAninch, J.W., Squamous cell carcinoma at the site of a Prince Albert's piercing (2010) J Sex Med, 7, pp. 2280-2283Favorito, L.A., Nardi, A.C., Ronalsa, M., Zequi, S.C., Sampaio, F.J., Glina, S., Epidemiologic study on penile cancer in Brazil (2008) Int Braz J Urol, 34, pp. 587-591Crispen, P.L., Mydlo, J.H., Penile intraepithelial neoplasia and other premalignant lesions of the penis (2010) Urol Clin North Am, 37, pp. 335-342Velázquez, E., Peix, A., Gómez-Alonso, A., Microorganisms and cancer: Scientific evidence and new hypotheses (2011) Cir Esp, 89, pp. 136-144Dalton-Griffin, L., Kellam, P., Infectious causes of cancer and their detection (2009) J Biol, 8, p. 67Urisman, A., Molinaro, R.J., Fischer, N., Plummer, S.J., Casey, G., Klein, E.A., Malathi, K., DeRisi, J.L., Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant (2006) PLoS Pathog, 2, pp. e25Silverman, R.H., Nguyen, C., Weight, C.J., Klein, E.A., The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome (2010) Nat Rev Urol, 7, pp. 392-402Mehrpour, M., Codogno, P., Prion protein: From physiology to cancer biology (2010) Cancer Lett, 290, pp. 1-23Gärtner, H.V., Seidl, C., Luckenbach, C., Schumm, G., Seifried, E., Ritter, H., Bültmann, B., Genetic analysis of a sarcoma accidentally transplanted from a patient to a surgeon (1996) N Engl J Med, 335, pp. 1494-1496Dingli, D., Nowak, M.A., Cancer biology: Infectious tumour cells (2006) Nature, 443, pp. 35-36Murgia, C., Pritchard, J.K., Kim, S.Y., Fassati, A., Weiss, R.A., Clonal origin and evolution of a transmissible cancer (2006) Cell, 126, pp. 477-487Rebbeck, C.A., Thomas, R., Breen, M., Leroi, A.M., Burt, A., Origins and evolution of a transmissible cancer (2009) Evolution, 63, pp. 2340-2349van den Top, J.G., de Heer, N., Klein, W.R., Ensink, J.M., Penile and preputial tumours in the horse: A retrospective study of 114 affected horses (2008) Equine Vet J, 40, pp. 528-532Gao, F., Bailes, E., Robertson, D.L., Chen, Y., Rodenburg, C.M., Michael, S.F., Cummins, L.B., Hahn, B.H., Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes (1999) Nature, 397, pp. 436-441Weiss, H.A., Thomas, S.L., Munabi, S.K., Hayes, R.J., Male circumcision and risk of syphilis, chancroid, and genital herpes: A systematic review and meta-analysis (2006) Sex Transm Infect, 82, pp. 101-109Gray, R.H., Kigozi, G., Serwadda, D., Makumbi, F., Watya, S., Nalugoda, F., Kiwanuka, N., Wawer, M.J., Male circumcision for HIV prevention in men in Rakai, Uganda: A randomised trial (2007) Lancet, 369, pp. 657-666Tobian, A.A., Serwadda, D., Quinn, T.C., Kigozi, G., Gravitt, P.E., Laeyendecker, O., Charvat, B., Gray, R.H., Male circumcision for the prevention of HSV-2 and HPV infections and syphilis (2009) N Engl J Med, 360, pp. 1298-130

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora