Acoustic cues to tonal contrasts in Mandarin: Implications for cochlear implants

The present study systematically manipulated three acoustic cues-fundamental frequency (f0), amplitude envelope, and duration-to investigate their contributions to tonal contrasts in Mandarin. Simplified stimuli with all possible combinations of these three cues were presented for identification to eight normal-hearing listeners, all native speakers of Mandarin from Taiwan. The f0 information was conveyed either by an f0-controlled sawtooth carrier or a modulated noise so as to compare the performance achievable by a clear indication of voice f0 and what is possible with purely temporal coding of f0. Tone recognition performance with explicit f0 was much better than that with any combination of other acoustic cues (consistently greater than 90% correct compared to 33%-65%; chance is 25%). In the absence of explicit f0, the temporal coding of f0 and amplitude envelope both contributed somewhat to tone recognition, while duration had only a marginal effect. Performance based on these secondary cues varied greatly across listeners. These results explain the relatively poor perception of tone in cochlear implant users, given that cochlear implants currently provide only weak cues to f0, so that users must rely upon the purely temporal (and secondary) features for the perception of tone. (c) 2008 Acoustical Society of America

Nonequilibrium thermodynamics of erasure with superconducting flux logic

We implement a thermal-fluctuation-driven logical bit reset on a superconducting flux logic cell. We show that the logical state of the system can be continuously monitored with only a small perturbation to the thermally activated dynamics at 500 mK. We use the trajectory information to derive a single-shot estimate of the work performed on the system per logical cycle. We acquire a sample of 10⁵ erasure trajectories per protocol and show that the work histograms agree with both microscopic theory and global fluctuation theorems. The results demonstrate how to design and diagnose complex, high-speed, and thermodynamically efficient computing using superconducting technology

Minimum Degree up to Local Complementation: Bounds, Parameterized Complexity, and Exact Algorithms

The local minimum degree of a graph is the minimum degree that can be reached by means of local complementation. For any n, there exist graphs of order n which have a local minimum degree at least 0.189n, or at least 0.110n when restricted to bipartite graphs. Regarding the upper bound, we show that for any graph of order n, its local minimum degree is at most 3n/8+o(n) and n/4+o(n) for bipartite graphs, improving the known n/2 upper bound. We also prove that the local minimum degree is smaller than half of the vertex cover number (up to a logarithmic term). The local minimum degree problem is NP-Complete and hard to approximate. We show that this problem, even when restricted to bipartite graphs, is in W[2] and FPT-equivalent to the EvenSet problem, which W[1]-hardness is a long standing open question. Finally, we show that the local minimum degree is computed by a O*(1.938^n)-algorithm, and a O*(1.466^n)-algorithm for the bipartite graphs

Complex dynamical networks constructed with fully controllable nonlinear nanomechanical oscillators

Control of the global parameters of complex networks has been explored experimentally in a variety of contexts. Yet, the more difficult prospect of realizing arbitrary network architectures, especially analog physical networks that provide dynamical control of individual nodes and edges, has remained elusive. Given the vast hierarchy of time scales involved, it also proves challenging to measure a complex network’s full internal dynamics. These span from the fastest nodal dynamics to very slow epochs over which emergent global phenomena, including network synchronization and the manifestation of exotic steady states, eventually emerge. Here, we demonstrate an experimental system that satisfies these requirements. It is based upon modular, fully controllable, nonlinear radio frequency nanomechanical oscillators, designed to form the nodes of complex dynamical networks with edges of arbitrary topology. The dynamics of these oscillators and their surrounding network are analog and continuous-valued and can be fully interrogated in real time. They comprise a piezoelectric nanomechanical membrane resonator, which serves as the frequency-determining element within an electrical feedback circuit. This embodiment permits network interconnections entirely within the electrical domain and provides unprecedented node and edge control over a vast region of parameter space. Continuous measurement of the instantaneous amplitudes and phases of every constituent oscillator node are enabled, yielding full and detailed network data without reliance upon statistical quantities. We demonstrate the operation of this platform through the real-time capture of the dynamics of a three-node ring network as it evolves from the uncoupled state to full synchronization

S-, P- and D-wave resonances in positronium-sodium and positronium-potassium scattering

Scattering of positronium (Ps) by sodium and potassium atoms has been investigated employing a three-Ps-state coupled-channel model with Ps(1s,2s,2p) states using a time-reversal-symmetric regularized electron-exchange model potential fitted to reproduce accurate theoretical results for PsNa and PsK binding energies. We find a narrow S-wave singlet resonance at 4.58 eV of width 0.002 eV in the Ps-Na system and at 4.77 eV of width 0.003 eV in the Ps-K system. Singlet P-wave resonances in both systems are found at 5.07 eV of width 0.3 eV. Singlet D-wave structures are found at 5.3 eV in both systems. We also report results for elastic and Ps-excitation cross sections for Ps scattering by Na and K.Comment: 9 pages, 5 figures, Accepted in Journal of Physics

EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology

Specialized postsynaptic structures known as dendritic spines are the primary sites of glutamatergic innervation at synapses of the CNS. Previous studies have shown that spines rapidly remodel their actin cytoskeleton to modify their shape and this has been associated with changes in synaptic physiology. However, the receptors and signaling intermediates that restructure the actin network in spines are only beginning to be identified. We reported previously that the EphA4 receptor tyrosine kinase regulates spine morphology. However, the signaling pathways downstream of EphA4 that induce spine retraction on ephrin ligand binding remain poorly understood. Here, we demonstrate that ephrin stimulation of EphA4 leads to the recruitment and activation of phospholipase Cgamma1 (PLCgamma1) in heterologous cells and in hippocampal slices. This interaction occurs through an Src homology 2 domain of PLCgamma1 and requires the EphA4 juxtamembrane tyrosines. In the brain, PLCgamma1 is found in multiple compartments of synaptosomes and is readily found in postsynaptic density fractions. Consistent with this, PLC activity is required for the maintenance of spine morphology and ephrin-induced spine retraction. Remarkably, EphA4 and PLC activity modulate the association of the actin depolymerizing/severing factor cofilin with the plasma membrane. Because cofilin has been implicated previously in the structural plasticity of spines, this signaling may enable cofilin to depolymerize actin filaments and restructure spines at sites of ephrin-EphA4 contact

Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD

There is now convincing evidence that the airway epithelium drives the pathogenesis of COPD. A major aspect of this is the disease-related reduction in barrier function that is potentiated by dysregulation of tight junction (TJ) protein complexes. However, a significant number of studies using in vitro smoke exposure models have not observed alterations in barrier permeability. We have previously shown that zinc (Zn) is an influential cytoprotective factor for the airway epithelium, and its depletion by cigarette smoke produces disease-related modifications consistent with inflammatory changes in COPD. We hypothesized that Zn deficiency is a significant co-stimulus with cigarette smoke extract (CSE) for potentiating the leaky barrier phenotype exhibited in COPD. We employed an ex vivo model of differentiated human airway epithelium exposed to Zn depletion and CSE to determine the contribution of Zn in maintaining normal epithelial permeability. Western blot analysis demonstrated a significant downregulation of the TJ proteins such as ZO-1 (-1.93-fold, P<0.05) and Claudin-1 (-3.37-fold, P<0.01) with the combination exposure. Assessment of barrier function via paracellular ionic conductance and tracer permeability also showed that Zn depletion was an important factor, which potentiated an increase in epithelial permeability (P<0.001 for both) compared to Zn depletion or CSE exposures in isolation. Visual inspection of the epithelium using transmission electron microscopy revealed a marked reduction in junction complexes between the adjacent airway epithelial cells treated with a combination of Zn depletion and CSE. These observations identify Zn deficiency as a significant codeterminant with CSE as a factor leading to an increase in airway epithelial permeability. Hence, as Zn dyshomeostasis has been reported in the airway epithelium exposed to chronic cigarette smoke and inflammation, targeting these phenomena may represent a promising strategy to ameliorate the leaky barrier phenotype that is synonymous with COPD.Eugene Roscioli, Hubertus PA Jersmann, Susan Lester, Arash Badiei, Andrew Fon, Peter Zalewski, Sandra Hodg

Exotic states in a simple network of nanoelectromechanical oscillators.

Synchronization of oscillators, a phenomenon found in a wide variety of natural and engineered systems, is typically understood through a reduction to a first-order phase model with simplified dynamics. Here, by exploiting the precision and flexibility of nanoelectromechanical systems, we examined the dynamics of a ring of quasi-sinusoidal oscillators at and beyond first order. Beyond first order, we found exotic states of synchronization with highly complex dynamics, including weak chimeras, decoupled states, traveling waves, and inhomogeneous synchronized states. Through theory and experiment, we show that these exotic states rely on complex interactions emerging out of networks with simple linear nearest-neighbor coupling. This work provides insight into the dynamical richness of complex systems with weak nonlinearities and local interactions

Nonequilibrium thermodynamics of erasure with superconducting flux logic

We implement a thermal-fluctuation-driven logical bit reset on a superconducting flux logic cell. We show that the logical state of the system can be continuously monitored with only a small perturbation to the thermally activated dynamics at 500 mK. We use the trajectory information to derive a single-shot estimate of the work performed on the system per logical cycle. We acquire a sample of 10⁵ erasure trajectories per protocol and show that the work histograms agree with both microscopic theory and global fluctuation theorems. The results demonstrate how to design and diagnose complex, high-speed, and thermodynamically efficient computing using superconducting technology