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Macroscopic isotope separation of uranium by selective photoionization
Genotypes and phenotypes for apolipoprotein E and Alzheimer disease in the Honolulu-Asia aging study
BACKGROUND: The utility of apolipoprotein E (ApoE) type as an indicator of
genetic susceptibility to Alzheimer disease (AD) depends on the
reliability of typing. Although ApoE protein isoform phenotyping is
generally assumed equivalent to genotyping from DNA, phenotype-genotype
differences have been reported. METHODS: ApoE genotype and phenotype
results were examined for 3564 older (ages 71-93 years) Japanese-American
male participants of the Honolulu-Asia Aging Study, an ongoing
population-based study of aging and dementia. RESULTS: Both methods
demonstrated similar associations of ApoE type with AD: a direct
association with ApoE4 and a less dramatic inverse association ApoE2.
Advanced age did not appear to influence the ApoE4-AD association. The
association with AD among ApoE4 homozygotes [odds ratio (OR) = 14.7] was
higher than expected based on an observed OR of 2.0 in heterozygotes.
Phenotype-genotype nonconcordance was more frequent for ApoE2 than for
ApoE4. The ApoE2 phenotype occurred at a frequency of 7.9% vs a genotype
frequency of 4.9%, corresponding to a probability of 56% that an
individual with ApoE2 phenotype had the same genotype. CONCLUSIONS:
Whereas E4 and E2 phenotypes and genotypes were comparably associated with
AD, neither method would be expected to substantially improve the
efficiency of case finding in the context of population screening beyond
prediction based on age and education. Nonconcordance of phenotype and
genotype was substantial for E2 and modest for E4 in this population. The
ApoE4-AD association was independent of age
Displaying the Heterogeneity of the SN 2002cx-like Subclass of Type Ia Supernovae with Observations of the Pan-STARRS-1 Discovered SN2009ku
SN2009ku, discovered by Pan-STARRS-1, is a Type Ia supernova (SNIa), and a
member of the distinct SN2002cx-like class of SNeIa. Its light curves are
similar to the prototypical SN2002cx, but are slightly broader and have a later
rise to maximum in g. SN2009ku is brighter (~0.6 mag) than other SN2002cx-like
objects, peaking at M_V = -18.4 mag - which is still significantly fainter than
typical SNeIa. SN2009ku, which had an ejecta velocity of ~2000 kms^-1 at 18
days after maximum brightness is spectroscopically most similar to SN2008ha,
which also had extremely low-velocity ejecta. However, SN2008ha had an
exceedingly low luminosity, peaking at M_V = -14.2 mag, ~4 mag fainter than
SN2009ku. The contrast of high luminosity and low ejecta velocity for SN2009ku
is contrary to an emerging trend seen for the SN2002cx class. SN2009ku is a
counter-example of a previously held belief that the class was more homogeneous
than typical SNeIa, indicating that the class has a diverse progenitor
population and/or complicated explosion physics. As the first example of a
member of this class of objects from the new generation of transient surveys,
SN2009ku is an indication of the potential for these surveys to find rare and
interesting objects.Comment: 7 pages, 3 figure
Correlated Supernova Systematics and Ground Based Surveys
Supernova distances provide a direct probe of cosmic acceleration,
constraining dark energy. This leverage increases with survey redshift depth at
a rate bounded by the systematic uncertainties. We investigate the impact of a
wavelength-dependent, global correlation model of systematics in comparison to
the standard local-redshift correlation model. This can arise from subclass
uncertainties as features in the supernova spectrum redshift out of the
observer photometric filters or spectral range. We explore the impact of such a
systematic on ground-based supernova surveys such as Dark Energy Survey and
LSST, finding distinctive implications. Extending the wavelength sensitivity to
1.05 microns through "extreme red" CCDs can improve the dark energy figure of
merit by up to a factor 2.Comment: 8 pages, 5 figure
Selection of Burst-like Transients and Stochastic Variables Using Multi-band Image Differencing in the PAN-STARRS1 Medium-deep Survey
We present a novel method for the light-curve characterization of Pan-STARRS1 Medium Deep Survey (PS1 MDS) extragalactic sources into stochastic variables (SVs) and burst-like (BL) transients, using multi-band image-differencing time-series data. We select detections in difference images associated with galaxy hosts using a star/galaxy catalog extracted from the deep PS1 MDS stacked images, and adopt a maximum a posteriori formulation to model their difference-flux time-series in four Pan-STARRS1 photometric bands g P1, r P1, i P1, and z P1. We use three deterministic light-curve models to fit BL transients; a Gaussian, a Gamma distribution, and an analytic supernova (SN) model, and one stochastic light-curve model, the Ornstein-Uhlenbeck process, in order to fit variability that is characteristic of active galactic nuclei (AGNs). We assess the quality of fit of the models band-wise and source-wise, using their estimated leave-out-one cross-validation likelihoods and corrected Akaike information criteria. We then apply a K-means clustering algorithm on these statistics, to determine the source classification in each band. The final source classification is derived as a combination of the individual filter classifications, resulting in two measures of classification quality, from the averages across the photometric filters of (1) the classifications determined from the closest K-means cluster centers, and (2) the square distances from the clustering centers in the K-means clustering spaces. For a verification set of AGNs and SNe, we show that SV and BL occupy distinct regions in the plane constituted by these measures. We use our clustering method to characterize 4361 extragalactic image difference detected sources, in the first 2.5 yr of the PS1 MDS, into 1529 BL, and 2262 SV, with a purity of 95.00% for AGNs, and 90.97% for SN based on our verification sets. We combine our light-curve classifications with their nuclear or off-nuclear host galaxy offsets, to define a robust photometric sample of 1233 AGNs and 812 SNe. With these two samples, we characterize their variability and host galaxy properties, and identify simple photometric priors that would enable their real-time identification in future wide-field synoptic survey
Selecting superluminous supernovae in faint galaxies from the first year of the Pan-STARRS1 Medium Deep Survey
The Pan-STARRS1 (PS1) survey has obtained imaging in five bands (griz yP1) over 10 Medium Deep Survey (MDS) fields covering a total of 70 square degrees. This paper describes the search for apparently hostless supernovae (SNe) within the first year of PS1 MDS data with an aim of discovering superluminous supernovae (SLSNe). A total of 249 hostless transients were discovered down to a limiting magnitude of MAB ∼ 23.5, of which 76 were classified as Type Ia supernovae (SNe Ia). There were 57 SNe with complete light curves that are likely core-collapse SNe (CCSNe) or type Ic SLSNe and 12 of these have had spectra taken. Of these 12 hostless, non-Type Ia SNe, 7 were SLSNe of type Ic at redshifts between 0.5 and 1.4. This illustrates that the discovery rate of type Ic SLSNe can be maximized by concentrating on hostless transients and removing normal SNe Ia. We present data for two possible SLSNe; PS1-10pm (z = 1.206) and PS1-10ahf (z = 1.1), and estimate the rate of type Ic SLSNe to be between 3+3−2×10−5 and 8+2−1×10−5 that of the CCSN rate within 0.3 ≤ z ≤ 1.4 by applying a Monte Carlo technique. The rate of slowly evolving, type Ic SLSNe (such as SN2007bi) is estimated as a factor of 10 lower than this range
Professionalism, Golf Coaching and a Master of Science Degree: A commentary
As a point of reference I congratulate Simon Jenkins on tackling the issue of professionalism in coaching. As he points out coaching is not a profession, but this does not mean that coaching would not benefit from going through a professionalization process. As things stand I find that the stimulus article unpacks some critically important issues of professionalism, broadly within the context of golf coaching. However, I am not sure enough is made of understanding what professional (golf) coaching actually is nor how the development of a professional golf coach can be facilitated by a Master of Science Degree (M.Sc.). I will focus my commentary on these two issues
Models for Type Ia supernovae and related astrophysical transients
We give an overview of recent efforts to model Type Ia supernovae and related
astrophysical transients resulting from thermonuclear explosions in white
dwarfs. In particular we point out the challenges resulting from the
multi-physics multi-scale nature of the problem and discuss possible numerical
approaches to meet them in hydrodynamical explosion simulations and radiative
transfer modeling. We give examples of how these methods are applied to several
explosion scenarios that have been proposed to explain distinct subsets or, in
some cases, the majority of the observed events. In case we comment on some of
the successes and shortcoming of these scenarios and highlight important
outstanding issues.Comment: 20 pages, 2 figures, review published in Space Science Reviews as
part of the topical collection on supernovae, replacement corrects typos in
the conclusions sectio
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