7,193 research outputs found
Image-based Quantification of 3D Morphology for Bifurcations in the Left Coronary Artery: Application to Stent Design
Background
Improved strategies for stentâbased treatment of coronary artery disease at bifurcations require a greater understanding of artery morphology. Objective
We developed a workflow to quantify morphology in the left main coronary (LMCA), left anterior descending (LAD), and left circumflex (LCX) artery bifurcations. Methods
Computational models of each bifurcation were created for 55 patients using computed tomography images in 3D segmentation software. Metrics including crossâsectional area, length, eccentricity, taper, curvature, planarity, branching law parameters, and bifurcation angles were assessed using openâsources software and custom applications. Geometric characterization was performed by comparison of means, correlation, and linear discriminant analysis (LDA). Results
Differences between metrics suggest dedicated or multistent approaches should be tailored for each bifurcation. For example, the side branch of the LCX (i.e., obtuse marginal; OM) was longer than that of the LMCA (i.e., LCXprox) and LAD (i.e., first diagonal; D1). Bifurcation metrics for some locations (e.g., LMCA Finet ratio) provide results and confidence intervals agreeing with prior findings, while revised metric values are presented for others (e.g., LAD and LCX). LDA revealed several metrics that differentiate between artery locations (e.g., LMCA vs. D1, LMCA vs. OM, LADprox vs. D1, and LCXprox vs. D1). Conclusions
These results provide a foundation for elucidating common parameters from healthy coronary arteries and could be leveraged in the future for treating diseased arteries. Collectively the current results may ultimately be used for design iterations that improve outcomes following implantation of future dedicated bifurcation stents
Evidence for a Photospheric Component in the Prompt Emission of the Short GRB120323A and its Effects on the GRB Hardness-Luminosity Relation
The short GRB 120323A had the highest flux ever detected with the Fermi/GBM.
Here we study its remarkable spectral properties and their evolution using two
spectral models: (i) a single emission component scenario, where the spectrum
is modeled by the empirical Band function, and (ii) a two component scenario,
where thermal (Planck-like) emission is observed simultaneously with a
non-thermal component (a Band function). We find that the latter model fits the
integrated burst spectrum significantly better than the former, and that their
respective spectral parameters are dramatically different: when fit with a Band
function only, the Epeak of the event is unusually soft for a short GRB, while
adding a thermal component leads to more typical short GRB values. Our
time-resolved spectral analysis produces similar results. We argue here that
the two-component model is the preferred interpretation for GRB 120323A, based
on: (i) the values and evolution of the Band function parameters of the two
component scenario, which are more typical for a short GRB, and (ii) the
appearance in the data of a significant hardness-intensity correlation,
commonly found in GRBs, when we employee two-component model fits; the
correlation is non-existent in the Band-only fits. GRB 110721A, a long burst
with an intense photospheric emission, exhibits the exact same behavior. We
conclude that GRB 120323A has a strong photospheric emission contribution,
first time observed in a short GRB. Magnetic dissipation models are difficult
to reconcile with these results, which instead favor photospheric thermal
emission and fast cooling synchrotron radiation from internal shocks. Finally,
we derive a possibly universal hardness-luminosity relation in the source frame
using a larger set of GRBs L,i=(1.59+/-0.84).10^50 (Epeak,i)^(1.33+/-0.07)
erg/s), which could be used as a possible redshift estimator for cosmology.Comment: 27 pages, 13 figures, Accepted by ApJ (April, 7th 2013
Low-Ni olivine from silicaundersaturated ultrapotassic rocks as evidence for carbonate metasomatism in the mantle
Trace Elements in Olivine in Italian Potassic Volcanic Rocks Distinguish Between Mantle Metasomatism by Carbonatitic and Silicate Melts
Comprehensive Observations of the Bright and Energetic Type Iax SN 2012Z: Interpretation as a Chandrasekhar Mass White Dwarf Explosion
We present UV through NIR broad-band photometry, and optical and NIR
spectroscopy of Type Iax supernova 2012Z. The data set consists of both early
and late-time observations, including the first late phase NIR spectrum
obtained for a spectroscopically classified SN Iax. Simple model calculations
of its bolometric light curve suggest SN 2012Z produced ~0.3 M_sun of (56)Ni,
ejected about a Chandrasekhar mass of material, and had an explosion energy of
~10^51 erg, making it one of the brightest and most energetic SN Iax yet
observed. The late phase NIR spectrum of SN 2012Z is found to broadly resemble
similar epoch spectra of normal SNe Ia; however, like other SNe Iax,
corresponding visual-wavelength spectra differ substantially compared to all
supernova types. Constraints from the distribution of IMEs, e.g. silicon and
magnesium, indicate that the outer ejecta did not experience significant mixing
during or after burning, and the late phase NIR line profiles suggests most of
the (56)Ni is produced during high density burning. The various observational
properties of SN 2012Z are found to be consistent with the theoretical
expectations of a Chandrasekhar mass white dwarf progenitor that experiences a
pulsational delayed detonation, which produced several tenths of a solar mass
of (56)Ni during the deflagration burning phase and little (or no) (56)Ni
during the detonation phase. Within this scenario only a moderate amount of
Rayleigh-Taylor mixing occurs both during the deflagration and fallback phase
of the pulsation, and the layered structure of the IMEs is a product of the
subsequent denotation phase. The fact that the SNe Iax population does not
follow a tight brightness-decline relation similar to SNe Ia can then be
understood in the framework of variable amounts of mixing during pulsational
rebound and variable amounts of (56)Ni production during the early subsonic
phase of expansion.Comment: Submitted to A&A, manuscript includes response to referee's comments.
39 pages, including 16 figures, 9 table
The Relationship Between Belief and Credence
Sometimes epistemologists theorize about belief, a tripartite attitude on which one can believe, withhold belief, or disbelieve a proposition. In other cases, epistemologists theorize about credence, a fine-grained attitude that represents oneâs subjective probability or confidence level toward a proposition. How do these two attitudes relate to each other? This article explores the relationship between belief and credence in two categories: descriptive and normative. It then explains the broader significance of the belief-credence connection and concludes with general lessons from the debate thus far
Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice
Activation of the hypothalamic-pituitary-adrenal axis results in the release of hormones from the adrenal glands, including glucocorticoids and mineralocorticoids. The physiological association between corticosteroids and cardiac disease is becoming increasingly recognized; however, the mechanisms underlying this association are not well understood. To determine the biological effects of corticosteroids on the heart, we investigated the impact of adrenalectomy in C57BL/6 male mice. Animals were adrenalectomized (ADX) at 1 month of age and maintained for 3â6 months after surgery to evaluate the effects of long-term adrenalectomy on cardiac function. Morphological evaluation suggested that ADX mice showed significantly enlarged hearts compared with age-matched intact controls. These changes in morphology correlated with deficits in left ventricular (LV) function and electrocardiogram (ECG) abnormalities in ADX mice. Correlating with these functional defects, gene expression analysis of ADX hearts revealed aberrant expression of a large cohort of genes associated with cardiac hypertrophy and arrhythmia. Combined corticosterone and aldosterone replacement treatment prevented the emergence of cardiac abnormalities in ADX mice, whereas corticosterone replacement prevented the effects of adrenalectomy on LV function but did not block the emergence of ECG alterations. Aldosterone replacement did not preserve the LV function but prevented ECG abnormalities. Together, the data indicate that adrenal glucocorticoids and mineralocorticoids either directly or indirectly have selective effects in the heart and their signaling pathways are essential in maintaining normal cardiac function
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