The Grizzly, May 1, 1981

Kane Appointed to Newly Created Position • St. Andrews Scholarship • APO Chapter Applauded for Achievement • Lewis Thomas to Address Graduates • Education Outside Classroom Stressed • Beta Sig Violates Pledging Guidelines • Transplanted Texan • Music News • Girls\u27 Track First • Lacrosse Tops Penn State • Tennis Completes Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1059/thumbnail.jp

The Grizzly, January 30, 1981

Gambling Investigation Prompts Student Withdrawals • Thornburgh Discusses Education At Conference • Todd Hall Fined $200 For Alcohol Violation • Tower Restoration Scheduled • McQuillan Presents Financial Aid Workshop • Magazine Addresses Students • J-Board Workings Explained By Barth • Fraternity Theories • Bids Distribution • Top Ten Albums of 1980 • Greaseband Unable To Return This Semester • Spiritwood: A Different Coffeehouse • Theatre: A Midsummer Night\u27s Dream • Shipping Delay Postpones NMD Window Installation • Departmental Focus: Health And Physical Education • Swim Coach Hopes For .500 Season • Men\u27s Basketball Holding 1st Place In MAC • Grapplers Having An Up & Down Year • Haag Leads Lady Hoopsters Past Widenerhttps://digitalcommons.ursinus.edu/grizzlynews/1050/thumbnail.jp

The Grizzly, November 21, 1980

Dean of Students\u27 Office Releases Vandalism Figures • Maintenance Working To Conserve Energy • Weight Room Relocated In Helfferich • College Union Attempts World\u27s Largest Molecule • Ursinus News In Brief: Espadas to speak today in Illinois; Maintenance planting new trees; Placement interviews coming soon • Rassias Method Explored for Languages • Journalism To Be Added To Curriculum • Medical Ethics Course Offered • Phil. & Rel. Dept. Lecture On Judaism • College To Host 43rd Messiah Performance • Foghat and Outlaws Perform for \u27Serious Rockers\u27 • Forum On Radiation Draws Mixed Views • Art Exhibit On Display In Wismer • Open House Planned By Astronomy Club • A Look At This Year\u27s Basketball Season • Cross Country To Compete In Nationals This Weekend • Gridders Lose Early Lead to Tie Gettysburghttps://digitalcommons.ursinus.edu/grizzlynews/1048/thumbnail.jp

The Grizzly, November 7, 1980

Reagan, Anderson Win In Campus Mock Election • Window Replacement To Start Soon • Weekend Crime Continues In New Men\u27s Dormitory • Bookstore Eyes Enlarged Facilities • Honorary Degrees Conferred At Founder\u27s Day • Library To Sponsor Open House • Breakdown For SAC Allocations Explored • Foreign Language Lunches Offered To Students • Another Viewpoint: I Object To War! • Students Do Their Stuff In Talent Show • Springsteen Unveils Interesting New Album • Party Brings Out Spirit On Halloween • Classics Club Underway • Why Carter Lost • UBEC Council Presents Three Faces Of Management • Soccer Finishes Season 7-7-1 • Breaks Carry Ursinus Past Lebanon Valley • Harriers Head Toward MACs • Field Hockey Enters Regional Competitionhttps://digitalcommons.ursinus.edu/grizzlynews/1046/thumbnail.jp

The Grizzly, October 3, 1980

Administration Focuses Attention On Pledging • Ritter Investigation Continues • Strangers Vandalize Beardwood Extinguishers • USGA Sponsors Alcohol Awareness Program • Women Experience the Excitement of Bid Day • College Disciplines Two Fraternities • Prof Appointed in Ec/BA • Photography Course Offered In Evening School • Values Education Examined By Committee • Candidates\u27 Platforms for Campus Elections • Classes of \u2781, \u2783 to Sponsor Gong Show • Album Review: Panorama: New View New Wave • Time Square Is Sheer Inspiration • Rush Returns to Philadelphia After Long Delay • Dingy Room Ideas Vol. II • Field Hockey Ties W&M; Beats Gettysburg • Volleyball Lookin\u27 Good • Awesome Widener Crunches Grizzlies • Sports Profile: Debbie Tweed • Cross Country Streak Alive • Despite 2-0 Loss, Booters Still Showing Promisehttps://digitalcommons.ursinus.edu/grizzlynews/1042/thumbnail.jp

The feasibility of a Comprehensive Resilience-building psychosocial Intervention (CREST) for people with dementia in the community: protocol for a non-randomised feasibility study

Background: A dementia diagnosis can prevent people from participating in society, leading to a further decline in cognitive, social and physical health. However, it may be possible for people with dementia to continue to live meaningful lives and continue to participate actively in society if a supportive psychosocial environment exists. Resilience theory, which focuses on strengthening personal attributes and external assets in the face of serious challenges, may provide a scaffold on which an inclusive multifaceted psychosocial supportive environment can be built. This protocol paper describes a study to determine the feasibility of conducting a multifaceted complex resilience building psychosocial intervention for people with dementia and their caregivers living in the community. Methods: This is a non-randomised feasibility study. Ten participants with dementia and their primary caregivers living in the community will be recruited and receive the CREST intervention. The intervention provides (a) a 7-week cognitive stimulation programme followed by an 8-week physical exercise programme for people with dementia and (b) a 6-week educational programme for caregivers. Members of the wider community will be invited to a dementia awareness programme and GP practices to a dementia training workshop. Trained professionals will deliver all intervention components. Outcomes will assess the feasibility and acceptability of all study processes. The feasibility and acceptability of a range of outcomes to be collected in a future definitive trial, including economic measurements, will also be explored. Finally, social marketing will be used to map a route toward stigma change in dementia for use in a subsequent trial. Quantitative feasibility outcome assessments will be completed at baseline and after completion of the 15-week intervention while qualitative data will be collected at recruitment, baseline, during and post-intervention delivery. Conclusion: This feasibility study will provide evidence regarding the feasibility and acceptability of a comprehensive multifaceted psychosocial intervention programme for people with dementia and their caregivers (CREST). The results will be used to inform the development and implementation of a subsequent RCT, should the findings support feasibility

The Grizzly, September 19, 1980

Reagan, Anderson Leading Carter In Campus Poll • Wismer Lunch Off to Optimistic Start • Explosive Bomb Found At NMD • College Van Policy Drastically Revised • Campus Expands With Enrollment • Bad Conditions Haunt New Women\u27s Dorm • Kane Appointed As New Executive Assistant • Ursinus Still Packing Them In • Ursinus News In Brief: Myrin Hosts Davison Exhibit; Davies Promoted In Admissions • TG Annex Almost Complete • Evening School Expands Services • Freshmen Class & USGA Treasurer Elections Coming Soon • Ron Baltz and Jenny Perform • Ritter Center To Open October 4 • For The Musically Inclined • WRUC - On The Air? • Yes A Maybe • Alternatives To Typical Parties • The Rush Is On • Switchboard Under New Operation • Police Rally To Cut Down Thefts • 1978 Alumnus Selected To Receive Award • Freshmen Offer Good Stats And Great Figures • Pre-Medical Evaluation Committee Reorganized • Bomberger Tower Finally To Be Replaced • Booters Sloppy in Close Call Over Drew • Delta Pi, ZX Defend Title; Intramural Football Underway • MAC Title: Cross Country Goal • Lack of Offense Hurts in Loss to Alfred • Hockey Starts Strong at Penn State Tourneyhttps://digitalcommons.ursinus.edu/grizzlynews/1040/thumbnail.jp

Fasting Induces the Expression of PGC-1α and ERR Isoforms in the Outer Stripe of the Outer Medulla (OSOM) of the Mouse Kidney

Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a member of the transcriptional coactivator family that plays a central role in the regulation of cellular energy metabolism under various physiological stimuli. During fasting, PGC-1α is induced in the liver and together with estrogen-related receptor a and γ (ERRα and ERRγ, orphan nuclear receptors with no known endogenous ligand, regulate sets of genes that participate in the energy balance program. We found that PGC-1α, ERRα and ERRγ was highly expressed in human kidney HK2 cells and that PGC-1α induced dynamic protein interactions on the ERRα chromatin. However, the effect of fasting on the expression of endogenous PGC-1α, ERRα and ERRγ in the kidney is not known.In this study, we demonstrated by qPCR that the expression of PGC-1α, ERRα and ERRγ was increased in the mouse kidney after fasting. By using immunohistochemistry (IHC), we showed these three proteins are co-localized in the outer stripe of the outer medulla (OSOM) of the mouse kidney. We were able to collect this region from the kidney using the Laser Capture Microdissection (LCM) technique. The qPCR data showed significant increase of PGC-1α, ERRα and ERRγ mRNA in the LCM samples after fasting for 24 hours. Furthermore, the known ERRα target genes, mitochondrial oxidative phosphorylation gene COX8H and the tricarboxylic acid (TCA) cycle gene IDH3A also showed an increase. Taken together, our data suggest that fasting activates the energy balance program in the OSOM of the kidney

The metabolic response of the Bradypus sloth to temperature

Poikilotherms and homeotherms have different, well-defined metabolic responses to ambient temperature (Ta), but both groups have high power costs at high temperatures. Sloths (Bradypus) are critically limited by rates of energy acquisition and it has previously been suggested that their unusual departure from homeothermy mitigates the associated costs. No studies, however, have examined how sloth body temperature and metabolic rate vary with Ta. Here we measured the oxygen consumption (VO2) of eight brown-throated sloths (B. variegatus) at variable Ta’s and found that VO2 indeed varied in an unusual manner with what appeared to be a reversal of the standard homeotherm pattern. Sloth VO2 increased with Ta, peaking in a metabolic plateau (nominal ‘thermally-active zone’ (TAZ)) before decreasing again at higher Ta values. We suggest that this pattern enables sloths to minimise energy expenditure over a wide range of conditions, which is likely to be crucial for survival in an animal that operates under severe energetic constraints. To our knowledge, this is the first evidence of a mammal provisionally invoking metabolic depression in response to increasing Ta’s, without entering into a state of torpor, aestivation or hibernation