Entrepreneurs at Sea: Tom and Anne Foley

NEJE interviews Tom and Anne Foley, owners of a small, private, upscale charter operatio

Roles for Histones H4 Serine 1 Phosphorylation in DNA Double Strand Break Repair and Chromatin Compaction: A Dissertation

The study of DNA templated events is not complete without considering the chromatin environment. Histone modifications help to regulate gene expression, chromatin compaction and DNA replication. Because DNA damage repair must occur within the context of chromatin, many remodeling enzymes and histone modifications work in concert to enable access to the DNA and aid in restoration of chromatin after repair is complete. CK2 has recently been identified as a histone modifying enzyme. In this study we identify CK2 as a histone H3 tail kinase in vitro, identify the phospho-acceptor site in vitro, and characterize the modification in vivo in S. cerevisiae. We also characterize the DNA damage phenotype of a strain lacking a single catalytic subunit of CK2. We further characterize the CK2- dependent phosphorylation of serine 1 of histone H4 in vivo. We find that it is recruited directly to the site of a DSB and this recruitment requires the SIN3/RPD3 histone deacetylase complex. We also characterize the contribution of H4 serine 1 phosphorylation in chromatin compaction by using reconstituted nucleosomal arrays to study folding in the analytical ultracentrifuge

Communicating Our Science to Our Customers:Drug Discovery in Five Simple Experiments

The complexities of modern drug discovery–an interdisciplinary process that often takes years and costs billions–can be extremely challenging to explain to a public audience. We present details of a 30 minute demonstrative lecture that uses well-known experiments to illustrate key concepts in drug discovery including synthesis, assay and metabolism

Panel. Spaces of Slavery

Ritual Architectures: Doorless and Makeshift Boundaries in Faulkner’s Slave Quarters / Amy Foley, Bryant UniversityFaulkner builds raced architectures throughout his writings, associating a lack of ornamentation in slave dwellings with an unfinished, nascent, or uncultivated way of life. Particularly in Go Down, Moses; Absalom, Absalom!; and “Red Leaves,” slaves live in cabins entirely without doors or with doors of a makeshift design as do the “domiciled” slaves of Thomas Sutpen and the McCaslins. Faulkner’s slave quarters are built from “odds and ends” and “refuse” that adorn sites of entry, repeatedly suggesting that the value of making a home is in the ritual or performance rather than in its material application. Faulkner conceptualizes how architectures direct, facilitate, and possibly “arrest” the motion of enslaved bodies relevant to contemporary theories of architecture and space, economy, labor models, and modes of observation and movement in industrial era work culture. His slave architectures anticipate and work out alternative models of supervision and relations between master and slave.Master/Slave Cartography: Mapping in The Unvanquished / Leigh Ann Litwiller Berte, Spring Hill CollegeThis paper examines Faulkner’s understanding of cartography as expressed in scenes within The Unvanquished (1938), a collection revised and published shortly after the author appended the first map of Yoknapatawpha to Absalom, Absalom!. In two key scenes, master and slave take turns as map makers, constructing “living maps” and what I call “trickster maps,” offering insight into the ways that maps and map making function as reflections of power and tools of subversion. Ultimately, these mapping scenes illuminate Faulkner’s larger conception of geography, unsettling our understandings of Yoknaptawpha as a geographical and imaginative entity. Faulkner offers a fluid understanding of the way that cartographers, land, events, and inhabitants intersect to construct contested, living maps of the world

The Argolid 800-600 BC: An archaeological survey

Ever since Schliemann's excavations in the Argolid, the area has been popular with archaeologists. One hundred years later the Geometric period is fairly well known in certain aspects but in other ways it is still unclear and even less is known about the immediately succeeding period, the early Archaic. The aim of this thesis, therefore, is to present the archaeological evidence for both the later part of the Geometric and early Archaic periods, the eighth and seventh centuries, and to examine the differences and the changes that occur within that time at the various sites, noting in particular the contrasts between the eighth and seventh century. This is a purely archaeological survey; historical accounts are not considered except in passing. The thesis attempts to put into proper perspective the position of Argos in relation to her neighbours in the Argolid, and the position of the eastern peninsula in relation to the central plain. Reasons are also suggested for the sudden and important changes noticeable in the seventh century. All the major facets of the archaeological evidence are presented, each in its own chapter beginning with the sites themselves, including distribution maps and a site index. Trends in settlement patterns from the LHIIIB to the Archaic period are noted, with particular attention to the Geometric and Archaic. The graves are then considered with an index of all graves of the eighth and seventh centuries. Contrasts and comparisons are made between the periods at each site. Pottery is examined by period and site, then metalwork in terms of the different types of artifacts found in the eighth and seventh centuries. The evidence of terracottas is treated in the same way and inscriptions and script are studied; finally the evidence for sanctuaries and cults brings together much of the previous material.<p

Criminal Procedure - Preventative Detention - Provision of 1984 Bail Reform Act Permitting Pretrial Detention of Arrestees Charged with Serious Felonies Who Are Found to Pose a Danger to the Community, Does Not, on Its Face, Violate Either the Fifth Amendment\u27s Due Process Clause or the Eighth Amendment\u27s Prohibition of Excessive Bail Recent Development.

Abstract Forthcoming

Providing Optimal Nutrition in Critical Care

Malnutrition among hospitalized patients is prevalent and associated with adverse outcomes. At the health care facility for which this quality improvement (QI) initiative was developed, patients were not consistently fed within the nationally recommended 48 hours. The purpose of this project was to facilitate the early initiation of enteral feedings to prevent malnutrition in a vulnerable patient group by development of an evidence-based enteral feeding policy, algorithm, and nursing education module. The find, organize, clarify, understand, select, plan, do, check, and act model provided a systematic approach for development of the project. Validation of the QI initiative was through the use of Likert scale which was completed by 2 nurses and a head dietician. The content validity index average was 1.0 for the QI initiative products (policy, algorithm, educational module). Ten team members completed a summative evaluation of the educational module and presentation using a 7 item, Likert scale. Basic descriptive analyses were employed to analyze the data, revealing broad support for the module and the DNP student\u27s leadership. A recommendation was made to conduct an audit using a formal software program to quantify the number of patients who were not being fed within the time frame of 48 hours. Implementing an evidence-based enteral feeding protocol can be a significant intervention that produces better patient outcomes.The implications for social change in this project relates to improvements within the critical care environment

Hidden in Plain Sight: Manager-Employee Social Engagement Strategies

Employee engagement occurs at the ‘swirling intersection’ (Kahn, 1990, p. 719) of the manager-employee relationship; a multidimensional engagement relationship. However, research to date has focused on examining employees’ engagement relationships with their role, work or organisation, emphasising linear and transactional aspects of engagement. Interpersonal oriented research has been under-used to explore engagement. In this study, attachment theory is used as a social systems theory to examine the manager-employee interpersonal relationship as a means to understand engagement. Attachment theory research has identified strategic patterns of interaction within close relationships that have been associated with optimising the quality of exploration outside of these relationships. Attachment theory informed workplace research has identified individual differential use of attachment patterns at work with differences in engagement. However, different patterns of attachment in relation to engagement (a potential form of exploration) have yet to be examined within the interpersonal context of the manager-employee relationship. In this study it is proposed that managers and employees might: socially interact with each other when under pressure in unique and strategically patterned ways; and that these interaction patterns might also influence engagement. This thesis asks: how do managers and employees strategically manage their relationship to optimise their engagement at work? A sequential explanatory mixed methods design study is conducted. Attachment theory methods inform the development of a new concept and measure: manager-employee social engagement strategies. This measure is quantitatively tested in a survey study with managers (n=200) and employees (n=200). The quantitative survey is used to generate qualitative and interpersonal data about manager-employee social engagement strategies and engagement within a series of five qualitatively oriented case studies with manager-employee dyads. Quantitative analysis indicates three manager and three employee social engagement strategy measures. These measures each uniquely correlate with perceptions about engagement, such as job and organisation engagement. Qualitative findings from the manager-employee dyads show (when under pressure) that they employ various combinations of social strategies to engage with each other; including a possible fourth strategy. In turn, these strategies are both influenced by, and influence, engagement. In conjunction with the literature, these findings are formulated into the central contribution of this study: an attachment theory informed framework of manager-employee engagement. This multidimensional framework reconceptualises engagement as a dynamic system and centralises the interpersonal dimension; represented by the manager-employee relationship. This framework specifies simultaneous and multi-directional associations between (a) how managers and employees engage with each other, (b) their perceptions of engagement and attachment, and (c) their engagement. This research has theoretical and practical implications for the training and coaching of managers and employees. It highlights knowledge currently hidden in plain sight within the engagement field that can be used to change: how we interact with each other when under pressure and stress as a route to changing our perceptions about engagement; and our engagement. This research confirms the relevance of a future research agenda that places the manager-employee relationship at the centre of engagement

Criminal Procedure - Preventative Detention - Provision of 1984 Bail Reform Act Permitting Pretrial Detention of Arrestees Charged with Serious Felonies Who Are Found to Pose a Danger to the Community, Does Not, on Its Face, Violate Either the Fifth Amendment\u27s Due Process Clause or the Eighth Amendment\u27s Prohibition of Excessive Bail Recent Development.

Abstract Forthcoming