3,912 research outputs found

    Control Plane Compression

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    We develop an algorithm capable of compressing large networks into a smaller ones with similar control plane behavior: For every stable routing solution in the large, original network, there exists a corresponding solution in the compressed network, and vice versa. Our compression algorithm preserves a wide variety of network properties including reachability, loop freedom, and path length. Consequently, operators may speed up network analysis, based on simulation, emulation, or verification, by analyzing only the compressed network. Our approach is based on a new theory of control plane equivalence. We implement these ideas in a tool called Bonsai and apply it to real and synthetic networks. Bonsai can shrink real networks by over a factor of 5 and speed up analysis by several orders of magnitude.Comment: Extended version of the paper appearing in ACM SIGCOMM 201

    Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation

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    ACKNOWLEDGMENTS We acknowledge Jennifer Lodge, Woei Lam, and Rajendra Upadhya for developing and sharing the chitin and chitosan MTBH assay. We thank Todd Brennan of Duke University for providing MyD88-deficient mice. We acknowledge Neil Gow for providing access to the Dionex HPAEC-PAD instrumentation. We also acknowledge Connie Nichols for critical reading of the manuscript. These experiments were supported by an NIH grant to J.A.A. and F.L.W., Jr. (R01 AI074677). C.M.L.W. was supported by a fellowship provided through the Army Research Office of the Department of Defense (no. W911NF-11-1-0136 f) (F.L.W., Jr.). J.W., L.W., and C.M. were supported by the Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the MRC, Centre for Medical Mycology (MR/N006364/1). FUNDING INFORMATION MRC Centre for Medical MycologyMR/N006364/1 Carol A. Munro HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) https://doi.org/10.13039/100000060R01 AI074677J. Andrew Alspaugh Wellcome https://doi.org/10.13039/100010269097377 Carol A. Munro DOD | United States Army | RDECOM | Army Research Office (ARO) https://doi.org/10.13039/100000183W911NF-11-1-0136 f Chrissy M. Leopold WagerPeer reviewedPublisher PD

    Aquaculture Law in the North Central States: A Digest of State Statutes Pertaining to the Production and Marketing of Aquacultural Products

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    One of the barriers to the growth and development of the aquaculture industry in the 12-state North Central region is a lack of comprehensive information on the state laws and regulations that affect the industry. The North Central Regional Aquaculture Center and its advisory committees quickly recognized this problem and made it one of their highest priorities for research. Among the factors that cause the confusion are the many aspects or stages of producing and marketing aquacultural products. The long and complex chain of production, transportation and marketing may include issues such as land use planning and zoning, water pollution and state fisheries regulations, transportation requirements and food quality standards. Many public policies and a wide variety of public agencies are involved in regulating these aspects of aquacultural production and marketing

    Labor and Employment: The Battle for the Gig Economy

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    The following is a transcript of a 2016 Federalist Society panel entitled Labor & Employment Law: The Battle for the Gig Economy. The panel originally occurred on November 17, 2016 during the National Lawyers Convention in Washington, D.C. The panelists were: Mark Brnovich, Attorney General, Arizona; Mr. Mark Floyd, Senior Director and Global Relations Lead, Uber Technologies Inc.; Mr. Randel K. Johnson, Senior Vice President, Labor, Immigration and Employee Benefits, U.S. Chamber of Commerce; and Mr. Bill Samuel, Director of Government Affairs, AFL-CIO. The moderator was the Honorable Judge Thomas M. Hardiman of the U.S. Court of Appeals, Third Circuit

    Global tuberculosis targets and milestones set for 2016-2035: definition and rationale.

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    BACKGROUND: Global tuberculosis (TB) targets were set as part of the World Health Organization's End TB Strategy (2016-2035) and the Sustainable Development Goals (2016-2030). OBJECTIVE: To define and explain the rationale for these targets. DESIGN: Scenarios for plausible reductions in TB deaths and cases were developed using empirical evidence from best-performing countries and modelling of the scale-up of under-used interventions and hypothetical TB vaccines. Results were discussed at consultations in 2012 and 2013. A final proposal was presented to the World Health Assembly in 2014 and unanimously endorsed by all Member States. RESULTS: The 2030 targets are a 90% reduction in TB deaths and 80% reduction in TB incidence compared with 2015 levels. The 2035 targets are for reductions of 95% and 90%, respectively. A third target-that no TB-affected households experience catastrophic costs due to the disease by 2020-was also agreed. CONCLUSION: The global TB targets and milestones set for the period 2016-2035 are ambitious. Achieving them requires concerted action on several fronts, but two things are fundamental: 1) progress towards universal health coverage to ensure that everyone with TB can access high-quality treatment; and 2) substantial investment in research and development for new tools to prevent TB disease among the approximately 1.7 billion people infected

    GRIDKIT: Pluggable overlay networks for Grid computing

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    A `second generation' approach to the provision of Grid middleware is now emerging which is built on service-oriented architecture and web services standards and technologies. However, advanced Grid applications have significant demands that are not addressed by present-day web services platforms. As one prime example, current platforms do not support the rich diversity of communication `interaction types' that are demanded by advanced applications (e.g. publish-subscribe, media streaming, peer-to-peer interaction). In the paper we describe the Gridkit middleware which augments the basic service-oriented architecture to address this particular deficiency. We particularly focus on the communications infrastructure support required to support multiple interaction types in a unified, principled and extensible manner-which we present in terms of the novel concept of pluggable overlay networks

    Documentation of a Gulf Sturgeon Spawning Site on the Yellow River, Alabama, USA

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    The Gulf Sturgeon Recovery Plan (USFWS, GSMFC and NMFS 1995) stressed the need to provide maximum protection to Gulf sturgeon spawning habitat. The approach employed by various Gulf sturgeon researchers, including ourselves, to document spawning has been to identify potential spawning habitat on the basis of physical characteristics and/or tracking data, collect eggs, and then raise the eggs in the laboratory until the point where the larval fish can be identified (e.g., Marchant and Shutters 1996, Sulak and Clugston 1998, 1999). However, collecting eggs in any appreciable number is usually difficult, and these eggs may not always be viable upon return to the laboratory. Molecular methods provide an alternative means of identifying the species represented by an egg. Notable examples related to sturgeon conservation include cases where molecular markers were used to verify the sources of commercially available caviar (DeSalle and Birstein 1996, Birstein et al. 1999). Parauka and Giorgianni (2002) reported that potential Gulf sturgeon spawning habitat is present in the Yellow River; however, efforts to document spawning by the collection of eggs or larvae have been unsuccessful in the past. Herein, we report on the first successful collection of eggs from a potential spawning site on the Yellow River and the verification of their identity as Gulf sturgeon by using molecular methods

    Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice

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    A survey of performance enhancement of transmission control protocol (TCP) in wireless ad hoc networks

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    This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Springer OpenTransmission control protocol (TCP), which provides reliable end-to-end data delivery, performs well in traditional wired network environments, while in wireless ad hoc networks, it does not perform well. Compared to wired networks, wireless ad hoc networks have some specific characteristics such as node mobility and a shared medium. Owing to these specific characteristics of wireless ad hoc networks, TCP faces particular problems with, for example, route failure, channel contention and high bit error rates. These factors are responsible for the performance degradation of TCP in wireless ad hoc networks. The research community has produced a wide range of proposals to improve the performance of TCP in wireless ad hoc networks. This article presents a survey of these proposals (approaches). A classification of TCP improvement proposals for wireless ad hoc networks is presented, which makes it easy to compare the proposals falling under the same category. Tables which summarize the approaches for quick overview are provided. Possible directions for further improvements in this area are suggested in the conclusions. The aim of the article is to enable the reader to quickly acquire an overview of the state of TCP in wireless ad hoc networks.This study is partly funded by Kohat University of Science & Technology (KUST), Pakistan, and the Higher Education Commission, Pakistan
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