Clinical characteristics of studied infants reported as median and [range].

<p>In infants with (sub)clinical seizures, a distinction was made between seizures that responded to anti epileptic drugs within the first 48 h after birth and seizures that required treatment beyond 72 h. Follow-up data, including the Griffiths' Developmental Quotient (DQ) are given for those infants who were tested between the age of 18 and 24 months.</p>¶<p>Main trunk MCA vs other strokes.</p

Median rADC values of infants with HIE as reported by McKinstry et al. [10] and Bednarek et al. [34].

<p>Both studies performed serial measurements, which were compared to ADC values of healthy controls. In the study of Bednarek, infants received therapeutic hypothermia. Based on MRI, the patterns of injury were classified as mild/moderate or severe. On some days no data (n.d.) were available.</p

Time course of the ADC values.

<p>ADC values were determined in the core of the stroke in 36 infants with a MCA main trunk (•), anterior MCA trunk (▵), posterior MCA trunk (▿), lenticulostriate branches (⋄), cortical branch (□) and PCA (+) stroke. The regression lines for the linear (dashed line) and quadratic regression (continuous line) are depicted. Two infants who were scanned following total body cooling are identified with an asterisk (*).</p

Time course of the ADC ratio.

<p>ADC ratios were determined in 35 infants with a MCA main trunk (•), anterior MCA trunk (▵), posterior MCA trunk (▿), lenticulostriate branches (⋄), cortical branch (□) and PCA (+) stroke. One infant with extensive bilateral ischemia was not included. The regression lines for the linear (dashed line) and quadratic regression (continuous line) are shown. Two infants who were scanned following total body cooling are identified with an asterisk (*).</p

Average regional increase factors for both hemispheres visualised on the inner cortical surface of one randomly chosen patient.

<p>The highest increase factor is shown in red and the lowest increase factor is shown in yellow; the range was set separately per descriptor. Note that this figure provides a visualisation of the data in the last column of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131552#pone.0131552.g005" target="_blank">Fig 5</a>.</p

26 week gestation infant; cUS and MRI at 32 weeks post-menstrual age.

<p>(a) cUS mid-coronal view, showing a focal lesion in the white matter also seen on early MRI-T2 weighted (b) and at TEA-T1 weighted MRI (c)</p

CoGM volume, median cortical thickness, gyrification index, and global mean curvature computed from the images acquired at 40 weeks PMA versus the width of the interhemispheric fissure, measured between the crowns of the superior frontal gyri.

<p>Spearman’s rank correlation coefficients (<i>ρ</i>) and the corresponding <i>p</i>-values are shown at the bottom right. No significant correlation was found for inner cortical surface area.</p

Гастроэзофагеальная рефлюксная болезнь. 2. Cовременная стратегия в диагностике и терапии

Приведены сведения о диагностике и современных медикаментозных препаратах, используемых в лечении больных ГЭРБ, их достоинствах и недостатках. Особое внимание уделено современным ингибиторам протонного насоса − рабепразолу и эзомепразолу. Представлены два принципа терапии ГЭРБ (Step up и Step down).The information about diagnosis and modern drugs used in treatment of gastroesophageal reflux disease (GERD) as well as their advantages and disadvantages is given. Special attention is paid to modern inhibitors of proton pump, rabeprasole and esomeprasole. Two principles of GERD treatment are presented (step up and step down)

Patient information and the number of patients with brain injury in this cohort.

<p>No patients with cystic periventricular leukomalacia and no patients with periventricular haemorrhagic infarction were found in this cohort.</p><p>Patient information and the number of patients with brain injury in this cohort.</p

Mean (<i>μ</i>) and corresponding standard deviation (<i>σ</i>) for the descriptors acquired at 30 and 40 weeks PMA, and their longitudinal increase factors.

<p>The computed descriptors were: UWM volume, CoGM volume, CSF volume, inner cortical surface area, outer cortical surface area, median cortical thickness, gyrification index, and global mean curvature of the inner and outer cortical surface together.</p><p>Mean (<i>μ</i>) and corresponding standard deviation (<i>σ</i>) for the descriptors acquired at 30 and 40 weeks PMA, and their longitudinal increase factors.</p