Neutrino signature of supernova hydrodynamical instabilities in three dimensions

The first full-scale three-dimensional (3D) core-collapse supernova (SN) simulations with sophisticated neutrino transport show pronounced effects of the standing accretion shock instability (SASI) for two high-mass progenitors (20 and 27 M_sun). In a low-mass progenitor (11.2 M_sun), large-scale convection is the dominant nonradial hydrodynamic instability in the postshock accretion layer. The SASI-associated modulation of the neutrino signal (80 Hz in our two examples) will be clearly detectable in IceCube or the future Hyper-Kamiokande detector, depending on progenitor properties, distance, and observer location relative to the main SASI sloshing direction. The neutrino signal from the next galactic SN can therefore diagnose the nature of the hydrodynamic instability.Comment: 6 pages, including 4 figures. Results unchanged. Matches published version in PRL. Animated visualization available at: http://www.mpa-garching.mpg.de/ccsnarchive/data/Hanke2013_movie/index.htm

Core-Collapse Supernovae: Reflections and Directions

Core-collapse supernovae are among the most fascinating phenomena in astrophysics and provide a formidable challenge for theoretical investigation. They mark the spectacular end of the lives of massive stars and, in an explosive eruption, release as much energy as the sun produces during its whole life. A better understanding of the astrophysical role of supernovae as birth sites of neutron stars, black holes, and heavy chemical elements, and more reliable predictions of the observable signals from stellar death events are tightly linked to the solution of the long-standing puzzle how collapsing stars achieve to explode. In this article our current knowledge of the processes that contribute to the success of the explosion mechanism are concisely reviewed. After a short overview of the sequence of stages of stellar core-collapse events, the general properties of the progenitor-dependent neutrino emission will be briefly described. Applying sophisticated neutrino transport in axisymmetric (2D) simulations with general relativity as well as in simulations with an approximate treatment of relativistic effects, we could find successful neutrino-driven explosions for a growing set of progenitor stars. First results of three-dimensional (3D) models have been obtained, and magnetohydrodynamic simulations demonstrate that strong initial magnetic fields in the pre-collapse core can foster the onset of neutrino-powered supernova explosions even in nonrotating stars. These results are discussed in the context of the present controversy about the value of 2D simulations for exploring the supernova mechanism in realistic 3D environments, and they are interpreted against the background of the current disagreement on the question whether the standing accretion shock instability (SASI) or neutrino-driven convection is the crucial agency that supports the onset of the explosion.Comment: 36 pages, 20 figures (43 eps files); submitted to Progress of Theoretical and Experimental Physics (PTEP

Self-sustained asymmetry of lepton-number emission: A new phenomenon during the supernova shock-accretion phase in three dimensions

During the stalled-shock phase of our 3D hydrodynamical core-collapse simulations with energy-dependent, 3-flavor neutrino transport, the lepton-number flux (nue minus antinue) emerges predominantly in one hemisphere. This novel, spherical-symmetry breaking neutrino-hydrodynamical instability is termed LESA for "Lepton-number Emission Self-sustained Asymmetry." While the individual nue and antinue fluxes show a pronounced dipole pattern, the heavy-flavor neutrino fluxes and the overall luminosity are almost spherically symmetric. Initially, LESA seems to develop stochastically from convective fluctuations, it exists for hundreds of milliseconds or more, and it persists during violent shock sloshing associated with the standing accretion shock instability. The nue minus antinue flux asymmetry originates mainly below the neutrinosphere in a region of pronounced proto-neutron star (PNS) convection, which is stronger in the hemisphere of enhanced lepton-number flux. On this side of the PNS, the mass-accretion rate of lepton-rich matter is larger, amplifying the lepton-emission asymmetry, because the spherical stellar infall deflects on a dipolar deformation of the stalled shock. The increased shock radius in the hemisphere of less mass accretion and minimal lepton-number flux (antinue flux maximum) is sustained by stronger convection on this side, which is boosted by stronger neutrino heating because the average antinue energy is higher than the average nue energy. Asymmetric heating thus supports the global deformation despite extremely nonstationary convective overturn behind the shock. While these different elements of LESA form a consistent picture, a full understanding remains elusive at present. There may be important implications for neutrino-flavor oscillations, the neutron-to-proton ratio in the neutrino-heated supernova ejecta, and neutron-star kicks, which remain to be explored.Comment: 21 pages, 15 figures; new results and new figure added; accepted by Ap

Documentary Linguistics and Computational Linguistics: A response to Brooks

National Foreign Language Resource Cente

RealCaPP: Real-time capable Plug & Produce communication platform with OPC UA over TSN for distributed industrial robot control

The industry of tomorrow is changing from central hierarchical industrial and robot controls to distributed controls on the industrial shop floor. These fundamental changes in network structure make it possible to implement technologies such as Plug & Produce. In other words, to integrate, change and remove devices without much effort at runtime. In order to achieve this goal, a uniform architecture with defined interfaces is necessary to establish real-time communication between the varying devices. Therefore, we propose an approach to use the combination of OPC UA and TSN to automatically configure real-time capable communication paths between robots and other cyber-physical components and execute real-time critical tasks in the distributed control system

Core-Collapse Supernovae: Explosion Dynamics, Neutrinos and Gravitational Waves

The quest for the supernova explosion mechanism has been one of the outstanding challenges in computational astrophysics for several decades. Simulations have now progressed to a stage at which the solution appears close and neutrino and gravitational wave signals from self-consistent explosion models are becoming available. Here we focus one of the recent advances in supernova modeling, the inclusion of general relativity in multi-dimensional neutrino hydrodynamics simulations, and present the latest simulation results for an 11.2 and a 15 solar mass progenitor. We also mention 3D effects as another aspect in supernova physics awaiting further, more thorough investigation.Comment: Contribution to the Proceedings of HANSE 2011 workshop, 8 pages, 4 figure

Phenotypic lentivirus screens to identify functional single domain antibodies

Manipulation of proteins is key in assessing their in vivo function. Although genetic ablation is straightforward, reversible and specific perturbation of protein function remains a challenge. Single domain antibody fragments, such as camelid-derived VHHs, can serve as inhibitors or activators of intracellular protein function, but functional testing of identified VHHs is laborious. To address this challenge, we have developed a lentiviral screening approach to identify VHHs that elicit a phenotype when expressed intracellularly. We identified 19 antiviral VHHs that protect human A549 cells from lethal infection with influenza A virus (IAV) or vesicular stomatitis virus (VSV), respectively. Both negative-sense RNA viruses are vulnerable to VHHs uniquely specific for their respective nucleoproteins. Antiviral VHHs prevented nuclear import of viral ribonucleoproteins or mRNA transcription, respectively, and may provide clues for novel antiviral reagents. In principle, the screening approach described here should be applicable to identify inhibitors of any pathogen or biological pathway. To identify the proteins essential to a biological pathway, small-molecule inhibitors or activators may be used to manipulate protein function transiently. Alternatively, screens involving mutagenesis, a reduction in levels or complete elimination of gene products are common. As applied to mammalian cells, these methods usually seek to achieve the removal of a protein from its normal biological context. Many proteins are multifunctional, or are components of multi-subunit complexes. Depletion of any single component may cause unexpected phenotypes due to the collapse of entire protein complexes. Small-molecule inhibitors often lack specificity and at best can target a fraction of all the proteins of interest. The screening of chemically diverse libraries must be paired with sophisticated methods to identify the molecular targets of any hit identified. Antibodies have been used as intracellular perturbants of protein function after microinjection or cytosolic expression of single-chain variable antibody fragments, but technical challenges have limited their application to few selected cases. In addition to conventional antibodies, the immune system of camelids generates heavy-chain-only antibodies. Their antigen binding site only consists of the variable domain of the heavy chain. This domain can be expressed on its own and is referred to as a VHH or nanobody, an entity that can retain its function in the reducing environment of the cytosol, independent of glycosylation. Many VHHs bind to their targets with affinities comparable to conventional antibodies. VHHs expressed in the cytosol can therefore act as molecular perturbants by occluding the interfaces involved in protein–protein interactions, by binding in the active sites of enzymes, or through the recognition or stabilization of distinct conformations of their targets. Both phage and yeast display, as well as mass spectrometry in combination with high-throughput sequencing, allow the identification of VHHs based on their binding properties. However, the identification of inhibitory VHHs remains a time-consuming process. VHHs obtained through biochemical screening methods must be expressed individually in the relevant cell type to test for the functional consequences of VHH expression. To address this challenge, we developed a phenotypic VHH screening method in living cells.National Institutes of Health (U.S.) (Health Pioneer Award

Life Cycle Assessment of a 5 MW Polymer Exchange Membrane Water Electrolysis Plant

This study performs a cradle-to-grave life cycle assessment of a 5 MW proton exchange membrane water electrolysis plant. The analysis follows a thorough engineering-based bottom-up design based on the electrochemical model of the system. Three scenarios are analyzed comprising a state-of-the-art (SoA) plant operated with the German electricity grid-mix, a SoA plant operated with a completely decarbonized energy system, and a future development plant electrolyzer with reduced energy and material demand, operated in a completely decarbonized energy system. The results display a global warming potential of 34 kg CO2-eq. kg-H2−1 and indicate a reduction potential of 89% when the plant is operated in a decarbonized energy system. A further reduction of 9% can be achieved by the technological development of the plant. Due to the reduced impacts of operation in a completely decarbonized energy system, the operation at locations with large offshore wind electricity capacity is recommended. In the construction phase, the stacks, especially the anode catalyst iridium, bipolar plates, and porous transport layers, are identified as dominant sources of the environmental impact. A sensitivity analysis shows that the environmental impact of the construction phase increases with a decreasing amount of operational full load hours of the plant