Expression of estrogenic response genes to different concentration of 17ß-estradiol in male mosquitofish (Gambusia yucatana)

The proximate composition, amino acids and fatty acids composition in the muscle of wild, inshore and offshore cage-cultured large yellow croaker, Pseudosciaena crocea (Richardson, 1846), were determined to identify nutritional differences. Wild fish groups showed highest content of moisture and crude protein, but the lowest lipid content. Offshore cage-cultured fish showed significantly higher content of moisture and crude protein content, but lower crude lipid content than inshore cage-cultured fish. The content of aspartic acid, glutamic acid, and alanine was higher in wild large yellow croaker than inshore cage-cultured groups, but similar to offshore cage-cultured fish. Significant lower contents of total amino acids, essential amino acids, non-essential amino acids and flavor-enhancing amino acids content were recorded in two cultured fish groups than those in wild group. While no major differences in fatty acids composition were found between wild and cage-cultured groups except for linoleic acid. The fish from offshore cages has much better nutrient profile than inshore cage cultured fish, but was still inferior compared to wild fish

The Mexican consensus on the diagnosis, treatment, and prevention of NSAID-induced gastropathy and enteropathy

Más de 30 millones de personas consumen diariamente antiinflamatorios noesteroideos (AINE) en el mundo, y este consumo se ve incrementado anualmente. Aunque losAINE poseen propiedades analgésicas y antiinflamatorias, sus eventos adversos gastrointesti-nales son bien reconocidos. En nuestro país no existía un consenso respecto al diagnóstico,tratamiento y prevención de la gastropatía y la enteropatía por AINE, por lo que la AsociaciónMexicana de Gastroenterología reunió a un grupo de expertos para establecer recomendacionesde utilidad para la comunidad médica. En este consenso se emitieron 33 recomendaciones. Elconsenso destaca que el riesgo de toxicidad gastrointestinal de los AINE varía según el fármacoempleado y su farmacocinética, lo cual debe ser considerado al momento de su prescripción. Losfactores de riesgo de complicación gastroduodenal por AINE son: antecedente de úlcera pép-tica, edad mayor a 65 a˜nos, dosis altas del AINE, infección por Helicobacter pylori (H.pylori), ypresencia de comorbilidades graves. Los síntomas y el da˜no gastroduodenal inducido por AINEson variables ya que puede cursar asintomático o manifestarse como anemia por deficiencia dehierro, hemorragia, estenosis y perforación. La cápsula endoscópica y la enteroscopia son méto-dos diagnósticos directos en la enteropatía por AINE. Respecto a la prevención, se recomiendaprescribir la dosis mínima necesaria de un AINE para obtener el efecto deseado y durante elmenor tiempo. Finalmente, los inhibidores de la bomba de protones (IBP) representan el están-dar de oro para la profilaxis y tratamiento de los efectos gastroduodenales, mas no son útilesen la enteropatía

Consenso mexicano sobre diagnóstico, prevención y tratamiento de la gastropatía y enteropatía por antiinflamatorios no esteroideos

Más de 30 millones de personas consumen diariamente antiinflamatorios no este-roideos (AINE) en el mundo y este consumo se ve incrementado a˜no tras a˜no. Aunque los AINEposeen propiedades analgésicas y antiinflamatorias, sus eventos adversos gastrointestinales sonbien reconocidos. En nuestro país no existía un consenso respecto al diagnóstico, tratamientoy prevención de la gastropatía y la enteropatía por AINE, por lo que la Asociación Mexicana deGastroenterología reunió a un grupo de expertos para establecer recomendaciones de utilidadpara la comunidad médica. En este consenso se emitieron 33 recomendaciones. El consensodestaca que el riesgo de toxicidad gastrointestinal de los AINE varía según el fármaco empleadoy su farmacocinética, lo cual debe ser considerado al momento de su prescripción. Los factoresde riesgo de complicación gastroduodenal por AINE son: antecedente de úlcera péptica, edadmayor de 65 a˜nos, dosis altas del AINE, infección por Helicobacter pylori y presencia de comor-bilidades graves. Los síntomas y el da˜no gastroduodenal inducido por AINE son variables, ya quepuede cursar asintomático o manifestarse como anemia por deficiencia de hierro, hemorragia,estenosis y perforación. La cápsula endoscópica y la enteroscopia son métodos diagnósticosdirectos en la enteropatía por AINE. Respecto a la prevención, se recomienda prescribir la dosismínima necesaria de un AINE para obtener el efecto deseado y durante el menor tiempo. Porúltimo, los inhibidores de la bomba de protones representan el estándar de oro para la profilaxisy tratamiento de los efectos gastroduodenales, mas no son útiles en la enteropatí

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at √s = 13 TeV

Data availability: Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in “CMS data preservation, re-use and open access policy” available online at: https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2 .A preprint of this article is available online at arXiv:2311.03261v2 [hep-ex] https://arxiv.org/abs/2311.03261v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-010 (CMS Public Pages)A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp → tH/A → tt¯c and pp → tH/A → tt¯u processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb−1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.SCOAP3

Search for long-lived heavy neutral leptons with lepton flavour conserving or violating decays to a jet and a charged lepton

A preprint version of the article is available at arXiv:2312.07484v3 [hep-ex], https://arxiv.org/abs/2312.07484 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-013 (CMS Public Pages)A search for long-lived heavy neutral leptons (HNLs) is presented, which considers the hadronic final state and coupling scenarios involving all three lepton generations in the 2-20 GeV HNL mass range for the first time. Events comprising two leptons (electrons or muons) and jets are analyzed in a data sample of proton-proton collisions, recorded with the CMS experiment at the CERN LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb−1. A novel jet tagger, based on a deep neural network, has been developed to identify jets from an HNL decay using various features of the jet and its constituent particles. The network output can be used as a powerful discriminating tool to probe a broad range of HNL lifetimes and masses. Contributions from background processes are determined from data. No excess of events in data over the expected background is observed. Upper limits on the HNL production cross section are derived as functions of the HNL mass and the three coupling strengths VℓN to each lepton generation ℓ and presented as exclusion limits in the coupling-mass plane, as lower limits on the HNL lifetime, and on the HNL mass. In this search, the most stringent limit on the coupling strength is obtained for pure muon coupling scenarios; values of |VμN|2 > 5 (4) × 10−7 are excluded for Dirac (Majorana) HNLs with a mass of 10 GeV at a confidence level of 95% that correspond to proper decay lengths of 17 (10) mm.SCOAP3

HERPETOFAUNA DE SANTIAGO JALAHUI, OAXACA, MEXICO

This study was conducted in the región of Santiago Jalahui, in the northeastern portion of the Mexican State of Oaxaca. Tropical rain forest was the original vegetation in the area, which has been substituted by different secondary plant communities. A total of 282 herpetofaunistic specimens were collected on a monthly basis during 29 effective days of fieid work comprising an annual cycle. Thirty four species were determined, ten amphibians and 24 reptiles. For each species we provide an account of general distribution and morphological characters. This work is the first inventory forthis area. We report for the first time precise localities in the state of Oaxaca for Sphenomorphus assatus assatus, Oxyrhopus petóla sebae and Dryadophis melanolomus veraecrucis, and the second record for Hyla miotympanum. We extend general distribution ranges of Anolis rodríguezi and state distribution of Hemidactylus frenatus and Leptophis mexicanus mexicanus.El estudio se realizó en la región de Santiago Jalahui al noreste del Estado de Oaxaca, México, zona que originalmente era selva alta perennifolia, pero que actualmente presenta diferentes comunidades de vegetación secundaria. Se capturaron 282 ejemplares de herpetofauna durante 29 días efectivos de trabajo repartidos en una colecta por mes durante un ciclo anual. Se determinaron 34 especies, 10 de anfibios y 24 de reptiles, de los que se proporciona su distribución general y algunas de sus características morfológicas. Este trabajo es el primer inventario de la herpetofauna en la zona. Asimismo, se obtuvieron los primeros registros con ubicación exacta en el estado de Oaxaca de Sphenomorphus assatus assatus, Oxyrhopus petóla sebae y de Dryadophis melanolomus veraecrucis y por segunda ocasión de Hyla miotympanum. Se amplía la distribución general de Anolis rodríguez y se extiende a nivel estatal la distribución de Hemidactylus frenatus y de Leptophis mexicanus mexicanus

Características clínicas de la pancreatitis aguda en México

Antecedentes: La frecuencia y la etiología de la pancreatitis aguda (PA) varían de acuerdo a la región geográfica. Objetivo: Determinar la frecuencia, etiología y mortalidad de la PA en una población mexicana. Pacientes y métodos: En un periodo de seis años estudiamos prospectivamente a todos los pacientes con un primer episodio de PA. Resultados: Se incluyeron a 605 pacientes con edad promedio de 40 años. El 64,00% tenían sobrepeso y/o obesidad por índice de masa corporal (IMC). La etiología fue biliar en 66,60%, ingesta de alcohol en 15,90%, hipertrigliceridemia en 7,80%, poscolangiopancreatografía retrógrada endoscópica (CPRE) en 2,10% y de etiología no determinada en 7,20%. Se sospechó infección pancreática en 70 pacientes, los cuales fueron puncionados por tomografía axial computarizada (TAC) y en 32 se diagnosticó infección pancreática, siendo el Staphylococcus spp el microorganismo más común. La mortalidad global fue del 5,00% ( 70 años con 10,00%). La etiología alcohólica tuvo una mayor frecuencia de necrosis, infección pancreática y mortalidad. Conclusiones: La etiología de la PA más frecuente es la biliar, pero la causada por alcohol tiene más complicaciones. La mortalidad global fue del 5,00% y ésta se incremento en los pacientes de mayor edad