Retinoic acid as a modulator of T cell immunity

Indexación: Scopus. DOAJ.Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surface integrity, erythrocyte production, reproduction, and normal immune function. Vitamin A deficiency is one of the most common micronutrient deficiencies worldwide and is associated with defects in adaptive immunity. Reports from epidemiological studies, clinical trials and experimental studies have clearly demonstrated that vitamin A plays a central role in immunity and that its deficiency is the cause of broad immune alterations including decreased humoral and cellular responses, inadequate immune regulation, weak response to vaccines and poor lymphoid organ development. In this review, we will examine the role of vitamin A in immunity and focus on several aspects of T cell biology such as T helper cell differentiation, function and homing, as well as lymphoid organ development. Further, we will provide an overview of the effects of vitamin A deficiency in the adaptive immune responses and how retinoic acid, through its effect on T cells can fine-tune the balance between tolerance and immunity.http://www.mdpi.com/2072-6643/8/6/34

Experimental proposal for accurate determination of the phase relaxation time and testing a formation of thermalized non-equilibrated matter in highly excited quantum many-body systems

We estimate how accurate the phase relaxation time of quantum many-body systems can be determined from data on forward peaking of evaporating protons from a compound nucleus. The angular range and accuracy of the data needed for a reliable determination of the phase relaxation time are evaluated. The general method is applied to analyze the inelastic scattering of 18 MeV protons from Pt for which previously measured double differential cross sections for two angles in the evaporating domain of the spectra show a strong forward peaking. A new experiment for an improved determination of the phase relaxation time is proposed. The experiment is also highly desirable for an accurate test of a formation of thermalized non-equilibrated matter in quantum many-body systems.Comment: 5 pages, 3 figure

Modelling of epitaxial graphene functionalization

A new model for graphene, epitaxially grown on silicon carbide is proposed. Density functional theory modelling of epitaxial graphene functionalization by hydrogen, fluorine and phenyl groups has been performed with hydrogen and fluorine showing a high probability of cluster formation in high adatom concentration. It has also been shown that the clusterization of fluorine adatoms provides midgap states in formation due to significant flat distortion of graphene. The functionalization of epitaxial graphene using larger species (methyl and phenyl groups) renders cluster formation impossible, due to the steric effect and results in uniform coverage with the energy gap opening.Comment: 15 pages, 4 figures, to appear in Nanotechnolog

Isocausal spacetimes may have different causal boundaries

We construct an example which shows that two isocausal spacetimes, in the sense introduced by Garc\'ia-Parrado and Senovilla, may have c-boundaries which are not equal (more precisely, not equivalent, as no bijection between the completions can preserve all the binary relations induced by causality). This example also suggests that isocausality can be useful for the understanding and computation of the c-boundary.Comment: Minor modifications, including the title, which matches now with the published version. 12 pages, 3 figure

Normal state magnetotransport properties of β\beta-FeSe superconductors

We present $\beta$-FeSe magnetotransport data, and describe them theoretically. Using a simplified microscopic model with two correlated effective orbitals, we determined the normal state electrical conductivity and Hall coefficient, using Kubo formalism. With model parameters relevant for Fe-chalcogenides, we describe the observed effect of the structural transition on the ab-plane electrical resistivity, as well as on the magnetoresistance. Temperature-dependent Hall coefficient data were measured at 16 Tesla, and their theoretical description improves upon inclusion of moderate electron correlations. We confirm the effect of the structural transition on the electronic structure, finding deformation-induced band splittings comparable to those reported in angle-resolved photoemission.Comment: 6 pages, 5 figure

Cluster Cores, Gravitational Lensing, and Cosmology

Many multiply--imaged quasars have been found over the years, but none so far with image separation in excess of 8\arcsec. The absence of such large splittings has been used as a test of cosmological models: the standard Cold Dark Matter model has been excluded on the basis that it predicts far too many large--separation double images. These studies assume that the lensing structure has the mass profile of a singular isothermal sphere. However, such large splittings would be produced by very massive systems such as clusters of galaxies, for which other gravitational lensing data suggest less singular mass profiles. Here we analyze two cases of mass profiles for lenses: an isothermal sphere with a finite core radius (density $\rho \propto (r^2+r_{core}^2)^{-1})$, and a Hernquist profile ($\rho \propto r^{-1}(r+a)^{-3}$). We find that small core radii $r_{core} \sim 30 h^{-1}$ kpc, as suggested by the cluster data, or large a \gsim 300 h^{-1} kpc, as needed for compatibility with gravitational distortion data, would reduce the number of large--angle splittings by an order of magnitude or more. Thus, it appears that these tests are sensitive both to the cosmological model (number density of lenses) and to the inner lens structure, which is unlikely to depend sensitively on the cosmology, making it difficult to test the cosmological models by large--separation quasar lensing until we reliably know the structure of the lenses themselves.Comment: 17 pages, uuencoded compressed tarred postscript file including text and 1 figure. To appear in January 20, 1996 issue of ApJ Letter

The distribution of oxygen at the Ni81Fe19/Ta interface

The knowledge of how oxygen atoms are distributed at a magnetic-metal / oxide, or magnetic-metal / non-magnetic-metal interface, can be an useful tool to optimize device production. Multilayered Ni81Fe19 / Ta samples consisting of 15 bilayers of 2.5 nm each, grown onto glass substrates by magnetron sputtering from Ni81Fe19 and Ta targets, have been investigated. X-ray absorption near edge structure, extended X-Ray absorption fine structure, small angle X-ray diffraction, and simulations, were used to characterize the samples. Oxygen atoms incorporated onto Ni81Fe19 films during O2 exposition are mainly bonded to Fe atoms. This partial oxidation of the Ni81Fe19 surface works as a barrier to arriving Ta atoms, preventing intermixing at the Ni81Fe19 / Ta interface. The reduction of the Ni81Fe19 surface by the formation of TaO x is observed.Comment: 14 pages, 9 figures, accepted for publication in Advances in Materials Science and Engineerin