Slow dynamics of solid proteins : Nuclear Magnetic Resonance relaxometry versus Dielectric Spectroscopy

Acknowledgement This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”).Peer reviewedPublisher PD

1H spin-lattice NMR relaxation in the presence of residual dipolar interactions : Dipolar relaxation enhancement

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”). The role of COST Action CA15209 (European Network on NMR Relaxometry) is also acknowledged.Peer reviewedPublisher PD

Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging

The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions primarily among the embedded SPIONs and then between the nanocomposites and the surroundings. Understanding the parameters that rule these interactions in real interacting (nano)systems still represents a challenge, making it difficult to predict or even explain the final (magnetic) behavior of such systems. Herein, a systematic study focused on the performance of a magnetic nanocomposite as a magnetic resonance imaging (MRI) contrast agent and magnetic hyperthermia (MH) effector is presented. The effect of stabilizing agents and magnetic loading on the final physicochemical and, more importantly, functional properties (i.e., blocking temperature, specific absorption rate, relaxivity) was studied in detail

Dynamics of Ionic Liquids in Confinement by Means of NMR Relaxometry—EMIM-FSI in a Silica Matrix as an Example

1H and 19F spin–lattice relaxation studies for 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)imide in bulk and mesoporous MCM-41 silica matrix confinement were performed under varying temperatures in a broad range of magnetic fields, corresponding to 1H resonance frequency from 5Hz to 30MHz.A thorough analysis of the relaxation data revealed a three-dimensional translation diffusion of the ions in the bulk liquid and two-dimensional diffusion in the vicinity of the confining walls in the confinement. Parameters describing the translation dynamics were determined and compared. The rotational motion of both kinds of ions in the confinement was described by two correlation times that might be attributed to anisotropic reorientation of these species

Water mobility in cheese by means of Nuclear Magnetic Resonance relaxometry

1H NMR relaxometry studies have been performed for different kinds of cheese in order to enquire into mechanisms of water mobility in the cheese structures. The exploited frequency range, from 4 kHz to 40 MHz, allowed probing water dynamics on a broad range of time scales. Two fractions of water of much different dynamical properties, referred to as confined-water and free-water, have been revealed. It has been demonstrated that dynamics of water molecules confined in the macromolecular matrix is about four orders of magnitude slower compared to bulk water, while the second fraction exhibits dynamics by slower only by one order of magnitude. It has turned out that the differences in the water behaviour and, hence, macroscopic properties of cheese are related to differences in the relative populations of these fractions and the portion of water molecules bound to proteins, while the time scale of water dynamics is similar for all cases