Multimodal Grammar Implementation

This paper reports on an implementation of a multimodal grammar of speech and co-speech gesture within the LKB/PET grammar engineering environment. The implementation extends the English Resource Grammar (ERG, Flickinger (2000)) with HPSG types and rules that capture the form of the linguistic signal, the form of the gestural signal and their relative timing to constrain the meaning of the multimodal action. The grammar yields a single parse tree that integrates the spoken and gestural modality thereby drawing on standard semantic composition techniques to derive the multimodal meaning representation. Using the current machinery, the main challenge for the grammar engineer is the nonlinear input: the modalities can overlap temporally. We capture this by identical speech and gesture token edges. Further, the semantic contribution of gestures is encoded by lexical rules transforming a speech phrase into a multimodal entity of conjoined spoken and gestural semantics.

Radiation therapy for primary carcinoma of the extrahepatic biliary system. An analysis of 63 cases.

From 1976 to 1988, 63 patients received radiation therapy for primary cancers of the extrahepatic biliary system (eight gallbladder and 55 extrahepatic biliary duct). Twelve patients underwent orthotopic liver transplantation. Chemotherapy was administered to 13 patients. Three patients underwent intraluminal brachytherapy alone (range, 28 to 55 Gy). Sixty patients received megavoltage external-beam radiation therapy (range, 5.4 to 61.6 Gy; median, 45 Gy), of whom nine received additional intraluminal brachytherapy (range, 14 to 45 Gy; median, 30 Gy). The median survival of all patients was 7 months. Sixty patients died, all within 39 months of radiation therapy. One patient is alive 11 months after irradiation without surgical resection, and two are alive 50 months after liver transplantation and irradiation. Symptomatic duodenal ulcers developed after radiation therapy in seven patients but were not significantly related to any clinical variable tested. Extrahepatic biliary duct cancers, the absence of metastases, increasing calendar year of treatment, and liver transplantation with postoperative radiation therapy were factors significantly associated with improved survival

Parallel Distributed Grammar Engineering for Practical Applications

Based on a detailed case study of parallel grammar development distributed across two sites, we review some of the requirements for regression testing in grammar engineering, summarize our approach to systematic competence and performance profiling, and discuss our experience with grammar development for a commercial application. If possible, the workshop presentation will be organized around a software demonstration

PAH in the laboratory and interstellar space

The theory that polycyclic aromatic hydrocarbons (PAHs) are a constituent of the interstellar medium, and a source of the IR emission bands at 3.3, 6.2, 7.7, 8.6, and 11.3 microns is being studied using PAH containing acid insoluble residue of the Orgueil CI meteorite and coal tar. FTIR spectra of Orgueil PAH material that has undergone thermal treatment, and a solvent insoluble fraction of coal tar that has been exposed to hydrogen plasma are presented. The UV excided luminescence spectrum of a solvent soluble coal tar film is also shown. Comparison of the lab measurements with observations appears to support the interstellar PAH theory, and shows the process of dehydrogenation expected to take place in the interstellar medium

Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors.

In 2017, the US Food and Drug Administration approved the first two novel cellular immunotherapies using synthetic, engineered receptors known as chimeric antigen receptors (CARs), tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (Yescarta), expressed by patient-derived T cells for the treatment of hematological malignancies expressing the B-cell surface antigen CD19 in both pediatric and adult patients. This approval marked a major milestone in the use of antigen-directed living drugs for the treatment of relapsed or refractory blood cancers, and with these two approvals, there is increased impetus to expand not only the target antigens but also the tumor types that can be targeted. This state-of-the-art review will focus on the challenges, advances, and novel approaches being used to implement CAR T-cell immunotherapy for the treatment of solid tumors

Inheritance and complementation : a case study of easy adjectives and related nouns

Mechanisms for representing lexically the bulk of syntactic and semantic information for a language have been under active development, as is evident in the recent studies contained in this volume. Our study serves to highlight some of the most useful tools available for structured lexical representation, in particular, (multiple) inheritance, default specification, and lexical rules. It then illustrates the value of these mechanisms in illuminating one corner of the lexicon involving an unusual kind of complementation among a group of adjectives exemplified by easy. The virtures of the structured lexicon are its succinctness and its tendency to highlight significant clusters of linguistic properties. From its succinctness follow two practical advantages, namely its ease of maintenance and modifiability. In order to suggest how important these may be practically, we extend the analysis of adjectival complementation in several directions. These further illustrate how the use of inheritance in lexical representation permits exact and explicit characterizations of phenomena in the language under study. We demonstrate how the use of the mechanisms employed in the analysis of easy enable us to give a unified account of related phenomena featuring nouns like pleasure, and even the adverbs (adjectival specifiers) too and enough. Along the way we motivate some elaborations of the Head-Driven Phrase Structure Grammar (HPSG) framework in which we couch our analysis, and offer several avenues for further study of this part of the English lexicon