Recomendações sobre revascularização do miocárdio

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Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

The promise of vascular reparative therapy in standby mode. How long before a final decision? Complete vessel wall regeneration and vascular scaffold resorption after left anterior descending reconstructions

The promise of vascular reparative therapy in standby mode. How long before a final decision? Complete vessel wall regeneration and vascular scaffold resorption after left anterior descending reconstructions

The Treatment of Aortic Valve Stenosis in Intermediate and Low-Risk Patients—When, How and Where

Until now, treatment of severe aortic stenosis (AS) is recommended after the disease becomes symptomatic or causes “silent” damages such as myocardial dysfunction [...

NVT ALLEGRA transcatheter heart valve for valve-in-valve procedures in failing surgical aortic bioprostheses: let us wait and see

transcatheter heart valve for valve-in-valve procedures in failing surgical aortic bioprosthese

Safety and efficacy of a cardiologist-only approach to deep sedation for electrical cardioversion

Electrical cardioversion is still the preferred method to restore sinus rhythm in patients with atrial fibrillation. The main disadvantage is that electrical cardioversion requires deep sedation, generally administered by anaesthesiologists, for safety concern. An exclusively cardiologic management of deep sedation should have the advantage to reduce resources and time consumed

A Modernity Different From All Others: Giuseppe Terragni in Rome, Dulux Gallery, Ground Floor, Melbourne School of Design AUSTRALIA

Un archivio di recente costituzione di opere e disegni di Giuseppe Terragni ha aperto la strada per una mostra itinerante internazionale che esplora i progetti di Terragni creati appositamente per Roma. Esporre presso la Scuola di Design di Melbourne nella Galleria Dulux, Terragni a Roma giustappone le immagini d'archivio con fotografie contemporanee e combina disegni, schizzi e arte provenienti da entrambi i progetti portati a termine e proposti. Terragni a Roma rivela un periodo unico della architettura italiana, con opere di Terragni rivelando una lotta tra moderno e tradizionale, e conciliare un linguaggio razionalista con uno spirito mediterraneo

Impella-protected PCI: the clinical results achieved so far

The ability of interventional cardiologists to identify high-risk percutaneous coronary intervention (PCI) patients, requires the integration of different features belonging to medical history, organ damage, coronary anatomy and the nature of the acute event. The selection of a subgroup of patients that could benefit from mechanical support during interventions is a key feature to success. The introduction of the Impella percutaneous axial pump have added an easy-to-set-up, less invasive and time-consuming active-support device to the interventional toolbox. Up to date, only few (four) randomized clinical trials (RCTs) have tried to address the clinical efficacy of Impella assistance for the treatment of this very high-risk population, but several large registries and multiple observational studies have demonstrated its safety, feasibility and hemodynamic performance. Although the largest RCT (PROTECT II) have been prematurely stopped due to the risk of futility despite the evidence of more complete revascularization in the Impella arm, the need for an adequate operator's learning curve must be considered. More recent insights suggest an effect of the device in optimizing end-organ perfusion and improving crucial parameters like renal function. Furthermore, available data suggest that vary early Impella support may improve patient's outcome in case of cardiogenic shock

Clinical impact of mitral regurgitation in aortic valve stenosis: Insight from effective regurgitant orifice area

Mechanisms leading to heart failure (HF) symptoms in aortic valve stenosis (AS) are contentious. We examined the impact of secondary mitral regurgitation (MR) on the symptomatic status in patients with AS