Some Aspects of Elizabeth Seton\u27s Spiritual/Theological World

Elizabeth Seton was influenced by three men: John Henry Hobart, an Episcopalian minister; Louis William Dubourg, a powerful Sulpician; and John Carroll, the bishop of Baltimore. Hobart represented minority views even within his own church because he was “High Church”— he believed in the importance of the episcopacy and of the sacraments. He inspired Elizabeth and strengthened her scriptural and sacramental piety. He provided readings that made her reason her decision about which church to belong to, although she did not rely on reason alone. Dubourg suggested that Elizabeth move to Baltimore, was highly instrumental in establishing Saint Joseph’s Academy, and was the first superior of the Sisters of Charity. Both Dubourg and Carroll believed that women’s education was as important as men’s and that education would be the means for Catholics to be accepted into American society. They thought that if Protestants and Catholics shared schools, they would also learn to live together. Elizabeth shared their ecumenism and accepted Protestant students at her academy. The Sulpicians’ influence on her is described, as is her experience as a member of Saint Patrick’s parish in New York

The Changing Character of the American Catholic Church 1810–1850

The Church in the United States faced three main problems between 1810 and 1850: anti-Catholic prejudice, the question of how to educate Catholic children, and the need for care of orphans and the sick. Anti-Catholic prejudice in the United States, which abated somewhat immediately after the Revolution, reached new heights with the massive Irish and German immigration in this period. Conflicts between Catholics and Protestants over which version of the Bible would be used in schools and the bishops’ insistence that interpretation be provided with Bible study contributed to the prejudice. It also led to the formation of a separate Catholic school system. The Sisters of Charity and other religious communities of women and men staffed institutions to care for those who needed it, regardless of religion or ability to pay. This helped combat the prejudice of the time

Handing on the Charism: Reporting on an Oral History Project

“Handing on the Charism,” part of a larger oral history project, was a series of interviews conducted in 2002 and 2003 among the Sisters of Charity of Saint Elizabeth, their associates, and other women the Sisters helped or influenced. The article gives this New Jersey community’s history, explains the project’s methodology, and provides long excerpts from the interview transcripts. It provides conclusions about how the Sisters’ charism is being passed down as well as recommendations for how to further include the laity in it

Parent-Child Dynamics and Emerging Adult Religiosity: Attachment, Parental Beliefs, and Faith Support

Parental religiosity has been shown to predict child and adolescent religiosity, but the role of parents in emerging adult religiosity is largely unknown. We explored associations among emerging adult religiosity, perceived parental religiosity, perceived similarity to mother\u27s and father\u27s religious beliefs, parental faith support, and parental attachment. Participants were 481 alumni of two Christian colleges and completed surveys online. Emerging adult religiosity (measured by Christian orthodoxy and intrinsic religiosity) was high and similar to parents\u27 religiosity. Perceived similarity to parents\u27 religious beliefs, faith support, and attachment to fathers predicted emerging adult religiosity. However, parental religiosity alone was a weak predictor and functioned as a negative suppressor variable when combined with similarity to parents\u27 beliefs and faith support. Findings underscore the importance of parental support and parent-child relationship dynamics more than the level of parental religiosity and point to possible unique roles for mothers and fathers in emerging adult religiosity

'A pathway to where?' Inquiry into understanding and reimagining social housing pathways. AHURI Final Report No.332

This report is the final report in a series for the AHURI Inquiry into understanding and reimagining social housing pathways. Housing pathways are the housing experiences of tenants and their households over time and space. They are not linear and may refer to changes in tenure, household form, experiences and attachment. This Inquiry draws on a range of data to understand: 1) how social housing pathways are conceptualised and constructed by operational housing policies and the wider social policy context in Australia; 2) what survey and administrative data tell us about who is moving into and out of social housing; and, 3) the lived experience of people who have moved into, within and/or out of social housing. These findings are brought together in this report to reimagine social housing pathways for positive housing outcomes for current and future tenants

Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer

INTRODUCTION: Mutations in known predisposition genes account for only about a third of all multiple-case breast cancer families. We hypothesized that germline mutations in FANCD2, BRIP1/BACH1, LMO4 and SFN may account for some of the unexplained multiple-case breast cancer families. METHODS: The families used in this study were ascertained through the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab). Denaturing high performance liquid chromatography (DHPLC) analysis of the coding regions of these four genes was conducted in the youngest affected cases of 30 to 267 non-BRCA1/2 breast cancer families. In addition, a further 399 index cases were also screened for mutations in two functionally significant regions of the FANCD2 gene and 253 index cases were screened for two previously reported mutations in BACH1 (p. P47A and p. M299I). RESULTS: DHPLC analysis of FANCD2 identified six silent exonic variants, and a large number of intronic variants, which tagged two common haplotypes. One protein truncating variant was found in BRIP1/BACH1, as well as four missense variants, a silent change and a variant in the 3' untranslated region. No missense or splice site mutations were found in LMO4 or SFN. Analysis of the missense, silent and frameshift variants of FANCD2 and BACH1 in relatives of the index cases, and in a panel of controls, found no evidence suggestive of pathogenicity. CONCLUSION: There is no evidence that highly penetrant exonic or splice site mutations in FANCD2, BRIP1/BACH1, LMO4 or SFN contribute to familial breast cancer. Large scale association studies will be necessary to determine whether any of the polymorphisms or haplotypes identified in these genes contributes to breast cancer risk

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To determine if senescent stromal cells influence tumorigenesis, we develop a mouse model that mimics the aged skin microenvironment. Using this model, here we find that senescent stromal cells are sufficient to drive localized increases in suppressive myeloid cells that contributed to tumour promotion. Further, we find that the stromal-derived senescence-associated secretory phenotype factor interleukin-6 orchestrates both increases in suppressive myeloid cells and their ability to inhibit anti-tumour T-cell responses. Significantly, in aged, cancer-free individuals, we find similar increases in immune cells that also localize near senescent stromal cells. This work provides evidence that the accumulation of senescent stromal cells is sufficient to establish a tumour-permissive, chronic inflammatory microenvironment that can shelter incipient tumour cells, thus allowing them to proliferate and progress unabated by the immune system

Laboratory-induced cue reactivity among individuals with prescription opioid dependence

Prescription opioid (PO) dependence is a critical health problem. Although examination of drug cue reactivity paradigms has advanced the understanding of risk factors for relapse for a variety of substances (e.g., cocaine, alcohol, nicotine), no PO specific drug cue paradigm has been developed. The current study addressed this gap in the literature and evaluated the ability of a newly developed PO drug cue paradigm to elicit subjective, physiological, and neuroendocrine changes among PO-dependent participants (n = 20) as compared to controls (n = 17). The drug cue paradigm included an induction script, viewing and handling paraphernalia (e.g., bottle of oxycontin pills, pill crusher) and watching a video depicting people using POs as well as places related to POs (e.g., pharmacies). Consistent with hypotheses, the PO group demonstrated significant pre- to post-cue increases on subjective ratings of craving, difficulty resisting POs, stress, and anger. The control group did not demonstrate significant changes on any of the subjective measures. Both the PO group and the control group evidenced significant pre- to post-cue increases in physiological responses (e.g., blood pressure, skin conductance), as expected given the arousing nature of the drug cue stimuli. The PO group, but not the control group, evidenced a significant pre- to post-cue increase in heart rate and salivary cortisol levels. The development and validation of a drug cue paradigm for POs may help inform future research and treatment development efforts for patients with PO dependence