Efficiency of new local method of treatment and prevention of inflammatory diseases of oral mucous membrane and parodontium in smokers

Treatment and prevention of inflammatory diseases of oral mucous membrane and parodontium at smokers is one of the most difficult problem in stomatology today.Purpose of research: estimation of clinical efficiency of local application of developed agent for oral cavity care apigel at treatment and prevention of inflammatory diseases of oral mucose membrane and parodontium at smokers. Local application of the new apigel based on propolis in the complex medical treatment of smokers patients favourably affects the clinical symptoms of inflammation in the oral mucous membrane and parodontium. As compared with patients who had traditional anti-inflammation therapy with the local use to the stomatologyc gel with chamomile, the patients treated with local application of new apigel had decline of the bleeding gums. The occurred more rapid improvement of inflammation painfulness, which correlated with the improvement of hygienic state of oral cavity and promoted to prevention of bacterial content of damaged mucous surfaces. Estimation of microvasculatory blood stream by the method of ultrasonic Doppler flowmetry revealed more rapid normalization of volume and linear high systole, speed of blood stream in the parodontal tissues in case of use of new local method that testified to the less pronounced inflammation of oral mucosa. The effect of the developed local agent in smokers patients with inflammatory diseases of oral mucose membrane and parodontium at smokers creates the best conditions for removal of violations of oral cavity microbiocenosis and restores structural-functional state of parodontium and oral mucosa.The authors came to conclusion that local application of the offered method of medical treatment reduces terms of renewal of structural-functional integrity of oral mucosa, helps in preventing development of inflammatory complication, improves the hygienic state of oral cavity, renders the regenerative action on oral mucosa tissues, which improves efficiency of medical treatment and quality of life of smokers patients

Perspectives of nasal administration of drugs in pharmacotherapy of anxiety disorders

В роботі розглянута широко поширена група психологічних розладів, яка протягом багатьох років зберігає тенденцію до подальшого розповсюдження серед населення, а саме тривожні розлади (ТР). Тому поліпшення методів фармакотерапії ТР не втрачає своєї актуальності. Одним із можливих методів збільшення ефективності фармакотерапії ТР може стати зміна шляху введення лікарського засобу (ЛЗ). Альтернативою поширеним зараз методам введення може стати назальне введення, яке здатне забезпечити пряме надходження ЛЗ до головного мозку, де знаходяться відділи ЦНС (мигдалевидне тіло, гіпокамп та таламус), що грають значну роль в патогенезі ТР. Незважаючи на додаткові вимоги до ЛЗ, викликані даним методом введення (ліпофільність, молекулярна маса діючої речовини та ін.), назальне введення може збільшити біодоступність та прискорити терапевтичну дію використаних препаратів.The work examines a widespread group of psychological disorders, which for many years has maintained a tendency to further spread among the population, namely, anxiety disorders (TR). Therefore, improving the methods of pharmacotherapy of TR does not lose its relevance. One of the possible methods of increasing the effectiveness of TR pharmacotherapy can be a change in the route of drug administration. An alternative to the currently common methods of administration can be nasal administration, which can ensure direct delivery of drugs to the brain, where the central nervous system departments (amygdala, hippocampus and thalamus) are located, which play a significant role in the pathogenesis of TR. Despite the additional requirements for drugs caused by this method of administration (lipophilicity, molecular weight of the active substance, etc.), nasal administration may increase the bioavailability and accelerate the therapeutic effect of the drugs used

Bronchial with plantain, thyme and vitamin С – herbal preparation of choice for complex treatment of upper airways’ inflammatory diseases

Целью исследований была клиническая оценка эффективности применения фитопрепарата Бронхиал с подорожником, чабрецом и витамином С в комплексном лечении воспалительных заболеваний верхних дыхательных путей. Установлено, что использование данного фитопрепарата улучшает клиническую картину и повышает эффективность и безопасность традиционных схем лечения воспалительных заболеваний верхних дыхательных путей.Метою досліджень була клінічна оцінка ефективності застосування фітопрепарату Бронхіол з подорожником, чебрецем і вітаміном С у комплексному лікуванні запальних захворювань верхніх дихальних шляхів. Встановлено, що застосування даного фітопрепарату покращує клінічну картину і посилює ефективність і безпеку традиційних схем лікування запальних захворювань верхніх дихальних шляхів.The purpose of researches was clinical rating of effectiveness of use of herbal preparation Bronchial with plantain, thyme and vitamin C for complex treatment of upper airways’ inflammatory diseases. It is established , that the use of this herbal preparation improves a clinical picture and raises effectiveness and safety of traditional schemes of treatment of upper airways’ inflammatory diseases

Разработка технологии лечебной маски с противовоспалительным действием на основе природного сырья

У результаті вивчення цілющих властивостей природних джерел лікувальних грязей України визначили доцільність створення нової парафармацевтичної форми із протизапальною дією. Експериментально обґрунтували вибір основи та розробили оптимальний склад і технологію лікувальної маски із протизапальною дією на основі природних ресурсів.In a process of studying the healing properties of natural sources of therapeutic mud in Ukraine the feasibility of developing a new dosage form with anti-inflammatory effect was determined. The mask basics were chosen and an optimal composition and technology of medical mask with anti-inflammatory effect on the basis of natural resources was developed.В результате изучения целебных свойств природных источников лечебных грязей Украины определили целесообразность создания новой парафармацевтической формы с противовоспалительным действием. Экспериментально обосновали выбор основы и разработали оптимальный состав и технологию лечебной маски с противовоспалительным действием на основе природных ресурсов

Sophora Japonica: the perspectives of use in a new medical form for prevention and treatment of couperose

Couperose affects up to 10% of people in the most socially active age and the lack of treatment leads to the development of later stages of rosacea. The research of a new treatment is caused by the increased cases of this disease. A significant role in couperose development is related to the vascular disturbances, that’s why we use rutin for an improving impact on those processes. After the detailed analysis of the plant material properties, we’ve chosen Sophora japonica as the main source of rutin for our new medical form for prevention and treatment of couperose

Local Use of Apisan Gel, A New Oral Care Product in the Treatment of Experimental Periodontitis Against the Background of Hyperacid Gastritis and Intoxication with Tobacco Smoke

The aim of the work was to substantiate the use of a newly created oral care product in the treatment of periodontal disease reconstructed against the background of hyperacidic gastritis under the conditions of tobacco smoke intoxication. Materials and Methods: The study was conducted in 2 stages. In the first stage, all experimental animals were divided into 4 groups: 1) intact, 2) with simulated periodontitis, 3) with reproduced periodontitis against the background of reproduced hyperacidic gastritis, 4) with reproduced periodontitis against the background of hyperacid gastritis under the conditions of tobacco smoking. Biochemical studies of gum homogenate with periodontitis in rats were conducted to determine the impact of stomach pathology and tobacco smoke as endogenous and exogenous risk factors. In stage 2, the effectiveness of local therapy with the use of the newly created oral care product and a comparator was studied in rats with reproduced periodontitis against the background of hyperacidic gastritis under the conditions of smoking. Results: In the experimental periodontitis against the background of hyperacidic gastritis under the conditions of tobacco smoking, there were significant changes in the periodontal tissues characteristic of the inflammatory process: the activity of peroxide oxidation of lipid (POL) increased, activity of the antioxidant system decreased, and inflammatory markers increased when nonspecific protection was reduced. Local therapy in the rats using the new “Apisan” gel resulted in the correction of certain metabolic disorders, faster elimination of the harmful effects of the damaging factors, and restoration of the condition of periodontal tissues compared with the use of the comparator, the Asepta gel. Conclusion: The therapeutic effectiveness of the new Apisan gel is due to the normalizing effect on the processes of POL, and inflammation and activation of the oral cavity protective systems during inflammatory periodontal disease occurring against the background of a concomitant stomach pathology, hyperacidic gastritis

Information technologies for decision-making on the conditions of spatially distributed objects

The problem of depression is becoming one of the central problems in the medical practice. In doing so, it has a significant impact on socio-psychological and economic aspects of society. According to Who, depression more than 120 million people worldwide are affected. It is reported that approximately one in three people has had a depressive episode at least once in their lives. Depression only 40% of patients are diagnosed, who suffer from this disorder. Of these, only 10–15% are prescribed therapy with antidepressants. According to the WHO forecast, there will be depression by 2025 occupy the 2nd place after coronary heart disease among the diseases that lead to disability. In most patients experience a decrease in quality of life

Pedagogical aspects in student education

The system of the educational process, which operated and continues to operate in any period of the educational process, provides for the acquisition of knowledge by students not for the sake of knowledge, but in order to carry out work on the education and development of the younger generation. Each teacher solves this task during the teaching of his subject. The success of the work depends primarily on how fully he is able to reveal the scientific and ideological potential of students, whether he has a dialectical approach to solving a number of methodological problems

Industrial drug technology. Modern perspective technologies in production soft pharmaceutical forms: educational guide (for independent work)

According to the content of the Drug Technology program, this manual presents the basic theoretical questions required to complete the course and also tests items to check the assimilation of educational material by students. The publication is recommended for the students of pharmaceutical faculties also for medical high school students

Industrial drug technology of solid pharmaceutical forms: educational guide (for independent work)

According to the content of the Drug Technology program, this manual presents the basic theoretical questions required to complete the course and also tests items to check the assimilation of educational material by students. The publication is recommended for the students of pharmaceutical faculties also for medical high school students