Hepatic but not intestinal CYP3A4 displays dose‐dependent induction by efavirenz in humans

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110078/1/cptclpt200260.pd

Popularizing Party Journalism in China in the Age of Social Media: The Case of Xinhua News Agency

The phenomenon of the “popularization” of journalism has become widespread in the process of media marketization, globalization and digitalization. This phenomenon has been studied mostly in the Anglo-American context. This article instead draws attention to China, where the tendency toward popularizing (party) journalism is also occurring but taking a rather different form. It focuses on the case of Xinhua News Agency—the pioneer as well as the most representative case of traditional party journalism in the country. The article considers to what extent Xinhua’s online media content concerning the ruling party since 1949—the Communist Party of China—has been popularized both in terms of content and style. The changes to online media content made by Xinhua are indicative of the extent to which it is possible to combine the status of a state-owned central news organization with a new journalistic orientation that seeks to make the messages from and about the party more appealing to technology-savvy and entertainment-driven audiences in the new media environment in mainland China

Passing the buck? Responsibility attribution and cognitive bias in multilevel democracies

<p>This paper explores the effect of national partisanship and Euroscepticism on individuals’ causal responsibility attribution in European multilevel democracies. It is particularly focused on the average differences in responsibility attribution in federal and non-federal states, as well as in countries belonging to different European Union enlargement waves. Using a pooled dataset of the 2004, 2009, and 2014 European Election Studies, results show that when poor economic outcomes are at stake, partisans of the national incumbent in federal states are more likely to assign responsibility to regional governments following a blame-attribution logic, while this logic is absent in non-federal states. Likewise, Eurosceptic individuals are more likely to assign responsibility to European authorities when they hold negative views of the economy and they belong to countries that have been European Union members for a longer period.</p

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. PKM2 interaction with phosphotyrosine-containing proteins inhibits enzyme activity and increases availability of glycolytic metabolites to support cell proliferation. This suggests that high pyruvate kinase activity may suppress tumor growth. We show that expression of PKM1, the pyruvate kinase isoform with high constitutive activity, or exposure to published small molecule PKM2 activators inhibit growth of xenograft tumors. Structural studies reveal that small molecule activators bind PKM2 at the subunit interaction interface, a site distinct from that of the endogenous activator fructose-1,6-bisphosphate (FBP). However, unlike FBP, binding of activators to PKM2 promotes a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. These data support the notion that small molecule activation of PKM2 can interfere with anabolic metabolism

Assumption without representation: the unacknowledged abstraction from communities and social goods

We have not clearly acknowledged the abstraction from unpriceable “social goods” (derived from communities) which, different from private and public goods, simply disappear if it is attempted to market them. Separability from markets and economics has not been argued, much less established. Acknowledging communities would reinforce rather than undermine them, and thus facilitate the production of social goods. But it would also help economics by facilitating our understanding of – and response to – financial crises as well as environmental destruction and many social problems, and by reducing the alienation from economics often felt by students and the public