Achieving Foundation Accountability and Transparency: Lessons From the Robert Wood Johnson Foundation’s \u3ci\u3eScorecard\u3c/i\u3e

· The purpose of this article is to help foundations in their accountability and transparency efforts by sharing lessons from one foundation’s journey to develop a scorecard. · A commitment to funding and sharing the results from rigorous evaluations set the tone for Robert Wood Johnson Foundation (RWJF) accountability. · The Scorecard is a powerful tool for RWJF to set goals, track organizational effectiveness, and motivate responses to shortcomings. · Foundations can tailor their scorecard to include what best serves their needs. · With its Scorecard, RWJF found that comparative and quantitative measures are the most powerful forces to motivate change. · Setting targets motivates staff to focus their efforts on certain areas and make improvements

Double Exchange in a Magnetically Frustrated System

This work examines the magnetic order and spin dynamics of a double-exchange model with competing ferromagnetic and antiferromagnetic Heisenberg interactions between the local moments. The Heisenberg interactions are periodically arranged in a Villain configuration in two dimensions with nearest-neighbor, ferromagnetic coupling $J$ and antiferromagnetic coupling $-\eta J$. This model is solved at zero temperature by performing a $1/\sqrt{S}$ expansion in the rotated reference frame of each local moment. When $\eta$ exceeds a critical value, the ground state is a magnetically frustrated, canted antiferromagnet. With increasing hopping energy $t$ or magnetic field $B$, the local moments become aligned and the ferromagnetic phase is stabilized above critical values of $t$ or $B$. In the canted phase, a charge-density wave forms because the electrons prefer to sit on lines of sites that are coupled ferromagnetically. Due to a change in the topology of the Fermi surface from closed to open, phase separation occurs in a narrow range of parameters in the canted phase. In zero field, the long-wavelength spin waves are isotropic in the region of phase separation. Whereas the average spin-wave stiffness in the canted phase increases with $t$ or $\eta$, it exhibits a more complicated dependence on field. This work strongly suggests that the jump in the spin-wave stiffness observed in Pr$_{1-x}$Ca$_x$MnO$_3$ with $0.3 \le x \le 0.4$ at a field of 3 T is caused by the delocalization of the electrons rather than by the alignment of the antiferromagnetic regions.Comment: 28 pages, 12 figure

The role of quasi-momentum in the resonant dynamics of the atom-optics kicked rotor

We examine the effect of the initial atomic momentum distribution on the dynamics of the atom-optical realisation of the quantum kicked rotor. The atoms are kicked by a pulsed optical lattice, the periodicity of which implies that quasi-momentum is conserved in the transport problem. We study and compare experimentally and theoretically two resonant limits of the kicked rotor: in the vicinity of the quantum resonances and in the semiclassical limit of vanishing kicking period. It is found that for the same experimental distribution of quasi-momenta, significant deviations from the kicked rotor model are induced close to quantum resonance, while close to the classical resonance (i.e. for small kicking period) the effect of the quasi-momentum vanishes.Comment: 10 pages, 4 figures, to be published in J. Phys. A, Special Issue on 'Trends in Quantum Chaotic Scattering

New direction for gamma-rays

The origin of energetic gamma-ray bursts is still unknown. But the detection of polarization of gamma-rays provides fresh insight into the mechanism driving these powerful explosions.Comment: Nature "News & Views", RE Coburn & Boggs (astro-ph/0305377

The BATSE experiment on the Compton Gamma Ray Observatory: Status and some early results

The Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory (GRO) is a sensitive all-sky detector system. It consists of eight uncollimated detectors at the corners of the spacecraft which have a total energy range of 15 keV to 100 MeV. The primary objective of BATSE is the detection, location, and study of gamma ray bursts and other transient sources. The instrement also has considerable capability for the study of pulsars, solar flares, and other discrete high energy sources. The experiment is now in full operation, detecting about one gamma ray burst per day. A brief description of the on-orbit performance of BATSE is presented, along with examples of early results from some of the gamma ray bursts

Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game

BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironment, effect tumour progression and represent a largely under appreciated therapeutic target. We use observations of primary tumor biology from prostate cancer to extrapolate a mathematical model: specifically; it has been observed that in prostate cancer three disparate cellular outcomes predominate: (i) the tumour remains well differentiated and clinically indolent - in this case the local stromal cells may act to restrain the growth of the cancer; (ii) early in its genesis the tumour acquires a highly malignant phenotype, growing rapidly and displacing the original stromal population (often referred to as small cell prostate cancer) - these less common aggressive tumours are relatively independent of the local microenvironment; and, (iii) the tumour co-opts the local stroma - taking on a classic stromagenic phenotype where interactions with the local microenvironment are critical to the cancer growth. METHODS: We present an evolutionary game theoretical construct that models the influence of tumour-stroma interactions in driving these outcomes. We consider three characteristic and distinct cellular populations: stromal cells, tumour cells that are self-reliant in terms of microenvironmental factors and tumour cells that depend on the environment for resources but can also co-opt stroma. 
RESULTS: Using evolutionary game theory we explore a number of different scenarios that elucidate the impact of tumour-stromal interactions on the dynamics of prostate cancer growth and progression and how different treatments in the metastatic setting can affect different types of tumors.
CONCLUSIONS: The tumour microenvironment plays a crucial role selecting the traits of the tumour cells that will determine prostate cancer progression. Equally important, treatments like hormone therapy affect the selection of these cancer phenotypes making it very important to understand how they impact prostate cancer’s somatic evolution

Giant Antiferromagnetically Coupled Moments in a Molecule-Based Magnet with Interpenetrating Lattices

The molecule-based magnet [Ru$_2$(O$_2$CMe)$_4$]$_3$[Cr(CN)$_6$] contains two weakly-coupled, interpenetrating sublattices in a body-centered cubic structure. Although the field-dependent magnetization indicates a metamagnetic transition from an antiferromagnet to a paramagnet, the hysteresis loop also exhibits a substantial magnetic remanance and coercive field uncharacteristic of a typical metamagnet. We demonstrate that this material behaves like two giant moments with a weak antiferromagnetic coupling and a large energy barrier between the orientations of each moment. Because the sublattice moments only weakly depend on field in the transition region, the magnetic correlation length can be directly estimated from the magnetization.Comment: 3 figure

Population Genetic Structure in a Social Landscape: Barley in a Traditional Ethiopian Agricultural System

Conservation strategies are increasingly driven by our understanding of the processes and patterns of gene flow across complex landscapes. The expansion of population genetic approaches into traditional agricultural systems requires understanding how social factors contribute to that landscape, and thus to gene flow. This study incorporates extensive farmer interviews and population genetic analysis of barley landraces (Hordeum vulgare) to build a holistic picture of farmer-mediated geneflow in an ancient, traditional agricultural system in the highlands of Ethiopia. We analyze barley samples at 14 microsatellite loci across sites at varying elevations and locations across a contiguous mountain range, and across farmer-identified barley types and management strategies. Genetic structure is analyzed using population-based and individual-based methods, including measures of population differentiation and genetic distance, multivariate Principal Coordinate Analysis, and Bayesian assignment tests. Phenotypic analysis links genetic patterns to traits identified by farmers. We find that differential farmer management strategies lead to markedly different patterns of population structure across elevation classes and barley types. The extent to which farmer seed management appears as a stronger determinant of spatial structure than the physical landscape highlights the need for incorporation of social, landscape, and genetic data for the design of conservation strategies in human-influenced landscapes