5,618 research outputs found

    Size-scaling of clump instabilities in turbulent, feedback regulated disks

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    We explore the scaling between the size of star-forming clumps and rotational support in massively star-forming galactic disks. The analysis relies on simulations of a clumpy galaxy at z=2z=2 and the observed DYNAMO sample of rare clumpy analogs at z0.1z\approx0.1 to test a predictive clump size scaling proposed by \citet{Fisher2017ApJ...839L...5F} in the context of the Violent Disk Instability (VDI) theory. We here determine the clump sizes using a recently presented 2-point estimator, which is robust against resolution/noise effects, hierarchical clump substructure, clump-clump overlap and other galactic substructure. After verifying Fisher's clump scaling relation for the DYNAMO observations, we explore whether this relation remains characteristic of the VDI theory, even if realistic physical processes, such as local asymetries and stellar feedback, are included in the model. To this end, we rely on hydrodynamic zoom-simulations of a Milky Way-mass galaxy with four different feedback prescriptions. We find that, during its marginally stable epoch at z=2z=2, this mock galaxy falls on the clump scaling relation, although its position on this relation depends on the feedback model. This finding implies that Toomre-like stability considerations approximately apply to large (kpc\sim\rm kpc) instabilities in marginally stable turbulent disks, irrespective of the feedback model, but also emphasizes that the global clump distribution of a turbulent disk depends strongly on feedback.Comment: Accepted by ApJ, no changes made. 11 pages, 4 figure

    Ferromagnetic semiconductor single wall carbon nanotube

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    Possibility of a ferromagnetic semiconductor single wall carbon nanotube (SWCNT), where ferromagnetism is due to coupling between doped magnetic impurity on a zigzag SWCNT and electrons spin, is investigate. We found, in the weak impurity-spin couplings, at low impurity concentrations the spin up electrons density of states remain semiconductor while the spin down electrons density of states shows a metallic behavior. By increasing impurity concentrations the semiconducting gap of spin up electrons in the density of states is closed, hence a semiconductor to metallic phase transition is take place. In contrast, for the case of strong coupling, spin up electrons density of states remain semiconductor and spin down electron has metallic behavior. Also by increasing impurity spin magnitude, the semiconducting gap of spin up electrons is increased.Comment: 10 pages and 9 figure

    Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts

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    BACKGROUND: Intracellular transport of cargoes including organelles, vesicles, signalling molecules, protein complexes, and RNAs, is essential for normal function of eukaryotic cells. The cytoplasmic dynein complex is an important motor that moves cargos along microtubule tracks within the cell. In mammals this multiprotein complex includes dynein intermediate chains 1 and 2 which are encoded by two genes, Dync1i1 and Dync1i2. These proteins are involved in dynein cargo binding and dynein complexes with different intermediate chains bind to specific cargoes, although the mechanisms to achieve this are not known. The DYNC1I1 and DYNC1I2 proteins are translated from different splice isoforms, and specific forms of each protein are essential for the function of different dynein complexes in neurons. METHODOLOGY/PRINCIPAL FINDINGS: Here we have undertaken a systematic survey of the dynein intermediate chain splice isoforms in mouse, basing our study on mRNA expression patterns in a range of tissues, and on bioinformatics analysis of mouse, rat and human genomic and cDNA sequences. We found a complex pattern of alternative splicing of both dynein intermediate chain genes, with maximum complexity in the embryonic and adult nervous system. We have found novel transcripts, including some with orthologues in human and rat, and a new promoter and alternative non-coding exon 1 for Dync1i2. CONCLUSIONS/SIGNIFICANCE: These data, including the cloned isoforms will be essential for understanding the role of intermediate chains in the cytoplasmic dynein complex, particularly their role in cargo binding within individual tissues including different brain regions

    Enhancement of cargo processivity by cooperating molecular motors

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    Cellular cargo can be bound to cytoskeletal filaments by one or multiple active or passive molecular motors. Recent experiments have shown that the presence of auxiliary, nondriving motors, results in an enhanced processivity of the cargo, compared to the case of a single active motor alone. We model the observed cooperative transport process using a stochastic model that describes the dynamics of two molecular motors, an active one that moves cargo unidirectionally along a filament track and a passive one that acts as a tether. Analytical expressions obtained from our analysis are fit to experimental data to estimate the microscopic kinetic parameters of our model. Our analysis reveals two qualitatively distinct processivity-enhancing mechanisms: the passive tether can decrease the typical detachment rate of the active motor from the filament track or it can increase the corresponding reattachment rate. Our estimates unambiguously show that in the case of microtubular transport, a higher average run length arises mainly from the ability of the passive motor to keep the cargo close to the filament, enhancing the reattachment rate of an active kinesin motor that has recently detached. Instead, for myosin-driven transport along actin, the passive motor tightly tethers the cargo to the filament, suppressing the detachment rate of the active myosin.Comment: 11 pages, 8 figures, submitted to PCC

    Bitcoin-Enhanced Proof-of-Stake Security: Possibilities and Impossibilities

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    Bitcoin is the most secure blockchain in the world, supported by the immense hash power of its Proof-of-Work miners. Proof-of-Stake chains are energy-efficient, have fast finality but face several security issues: susceptibility to non-slashable long-range safety attacks, low liveness resilience and difficulty to bootstrap from low token valuation. We show that these security issues are inherent in any PoS chain without an external trusted source, and propose a new protocol, Babylon, where an off-the-shelf PoS protocol checkpoints onto Bitcoin to resolve these issues. An impossibility result justifies the optimality of Babylon. A use case of Babylon is to reduce the stake withdrawal delay: our experimental results show that this delay can be reduced from weeks in existing PoS chains to less than 5 hours using Babylon, at a transaction cost of less than 10K USD per annum for posting the checkpoints onto Bitcoin.Comment: Forthcoming in IEEE Symposium on Security and Privacy 202

    Universality of the cross entropy in Z2\mathbb{Z}_2 symmetric monitored quantum circuits

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    The linear cross-entropy (LXE) has been recently proposed as a scalable probe of the measurement-driven phase transition between volume- and area-law-entangled phases of pure-state trajectories in certain monitored quantum circuits. Here, we demonstrate that the LXE can distinguish distinct area-law-entangled phases of monitored circuits with symmetries, and extract universal behavior at the critical points separating these phases. We focus on (1+1)-dimensional monitored circuits with an on-site Z2\mathbb{Z}_{2} symmetry. For an appropriate choice of initial states, the LXE distinguishes the area-law-entangled spin glass and paramagnetic phases of the monitored trajectories. At the critical point, described by two-dimensional percolation, the LXE exhibits universal behavior which depends sensitively on boundary conditions, and the choice of initial states. With open boundary conditions, we show that the LXE relates to crossing probabilities in critical percolation, and is thus given by a known universal function of the aspect ratio of the dynamics, which quantitatively agrees with numerical studies of the LXE at criticality. The LXE probes correlations of other operators in percolation with periodic boundary conditions. We show that the LXE is sensitive to the richer phase diagram of the circuit model in the presence of symmmetric unitary gates. Lastly, we consider the effect of noise during the circuit evolution, and propose potential solutions to counter it.Comment: 11+6 pages, 16 figure
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