Managing atrial fibrillation in the elderly: critical appraisal of dronedarone

Atrial fibrillation is the most commonly seen arrhythmia in the geriatric population and is associated with increased cardiovascular morbidity and mortality. Treatment of the elderly with atrial fibrillation remains challenging for physicians, because this unique subpopulation is characterized by multiple comorbidities requiring chronic use of numerous medications, which can potentially lead to severe drug interactions. Furthermore, age-related changes in the cardiovascular system as well as other physiological changes result in altered drug pharmacokinetics. Dronedarone is a new drug recently approved for the treatment of arrhythmias, such as atrial fibrillation and/or atrial flutter. Dronedarone is a benzofuran amiodarone analog which lacks the iodine moiety and contains a methane sulfonyl group that decreases its lipophilicity. These differences in chemical structure are responsible for making dronedarone less toxic than amiodarone which, in turn, results in fewer side effects. Adverse events for dronedarone include gastrointestinal side effects and rash. No dosage adjustments are required for patients with renal impairment. However, the use of dronedarone is contraindicated in the presence of severe hepatic dysfunction

HYACINTH MACAWS (ANODORHYNCHUS HYACINTHINUS, PSITTACIDAE) FEEDING ON TERMITES

Abstract ∙ Hyacinth Macaws (Anodorhynchus hyacinthinus) feed largely on palm seeds and fruits. Here, we report a pair of Hyacinth Macaws feeding on termites. We visited the nesting tree of a pair of Hyacinth Macaws at the southern border of the Brazilian Pantanal on a monthly basis during one year. Macaws were present during four of these visits, and we recorded them foraging on arboreal termites in their nesting tree during one of the visits. Using their beaks, both macaw individuals repeatedly broke away bark pieces from decaying branches, and handled them with beak and feet to ingest termites found on the inner side of the bark. Nesting in decaying trees likely increases opportunities for Hyacinth Macaws to find termites, and the feeding behavior of these macaws indicates that they are familiar with and able to consume termites. This is the first report of termite consumption by this species.Resumo ∙ Arara‐azul‐grande (Anodorhynchus hyacinthinus, Psittacidae) comendo cupins Indivíduos de Arara‐azul‐grande (Anodorhynchus hyacinthinus) consomem principalmente sementes de palmeiras e frutos. Reportamos aqui um casal de Araras‐azuis‐grandes consumindo cupins. Visitamos uma árvore de nidificação na borda sul do Pantanal brasileiro mensalmente durante um ano. As araras estavam presentes em quatro visitas, e registramos consumo de cupins presentes na árvore de nidificação em uma visita. As araras repetidamente retiravam com o bico pedaços de casca de ramos podres, e manuseavam os pedaços com o bico e os pés para ingerir cupins presentes na parte interna da casca. Nidificar em árvores senescentes provavelmente aumenta a oportunidade dessas araras encontrarem cupins, e o comportamento alimentar delas indica familiaridade e habilidade em consumilos. Esse é o primeiro registro de consumo de cupins por esta espécie.

Early Responses of Brassica oleracea Roots to Zinc Supply Under Sufficient and Sub-Optimal Phosphorus Supply

© Copyright © 2020 Pongrac, Fischer, Thompson, Wright and White. Shoot zinc (Zn) concentration in Brassica oleracea is affected by soil Zn and phosphorus (P) supply. Most problematic is the negative impact of P fertilizers on Zn concentrations in crops, which makes balancing yield and mineral quality challenging. To evaluate early molecular mechanisms involved in the accumulation of large shoot Zn concentrations regardless of the P supply, two B. oleracea accessions differing in root architecture and root exudates were grown hydroponically for two weeks with different combinations of P and Zn supply. Ionome profiling and deep RNA sequencing of roots revealed interactions of P and Zn in planta, without apparent phenotypic effects. In addition, increasing P supply did not reduce tissue Zn concentration. Substantial changes in gene expression in response to different P and/or Zn supplies in roots of both accessions ensured nutritionally sufficient P and Zn uptake. Numerous genes were differentially expressed after changing Zn or P supply and most of them were unique to only one accession, highlighting their different strategies in achieving nutrient sufficiency. Thus, different gene networks responded to the changing P and Zn supply in the two accessions. Additionally, enrichment analysis of gene ontology classes revealed that genes involved in lipid metabolism, response to starvation, and anion transport mechanisms were most responsive to differences in P and Zn supply in both accessions. The results agreed with previously studies demonstrating alterations in P and Zn transport and phospholipid metabolism in response to reduced P and Zn supply. It is anticipated that improved knowledge of genes responsive to P or Zn supply will help illuminate the roles in uptake and accumulation of P and Zn and might identify candidate genes for breeding high-yield-high-Zn brassicas

Könyvismertetések

Kovács Mónika: Kollektív emlékezet és holokausztmúlt Corvina, Budapest, 2016 Evolúciós pszichológia mesterfokon Szerkesztette: Gyuris Petra, Meskó Norbert Pécs, Pro Pannonia Kiadó, 2016, 480 oldal Pléh Csaba (szerk.) Információs eszközök és tanulás a kognitív pszichológiai kutatásokban Pszichológiai Szemle Könyvtár, 20. kötete, Akadémiai Kiadó, 201